Abstract: The present invention relates to new biomarkers for assessing ovarian cancer being more sensitive, particularly at early stage of disease. Moreover, the present invention relates to a method for assessing ovarian cancer from a patient to be examined, and to a kit for carrying out the method.

Abstract: The present invention relates to a method for the synthesis of double-stranded nucleic acids from a wide variety of samples and comprises the use of these nucleic acids for deep sequence analysis. Also, the present invention relates to specific reagents used in the method of the present invention. Further, the invention relates to kits comprising reagents for the method of the invention and use of said kits.

Abstract: The present invention relates to panels of methylation and mi RNA marker as well as their use in the prognosing, diagnosing and/or treatment of cancer, means for detecting said marker, kits comprising said means, and devices for analysing the marker panel.

Abstract: The present invention relates to new biomarkers for assessing ovarian cancer being more sensitive, particularly at early stage of disease. Moreover, the present invention relates to a method for assessing ovarian cancer from a patient to be examined, and to a kit for carrying out the method.

Abstract: The present invention is concerned with a method for diagnosing breast cancer in a subject comprising the steps of determining in a sample of a subject suspected to be afflicted with said breast cancer the amount of at least one miRNA or the amounts of at least the miRNAs of a combination of miRNAs selected from the group consisting of: (i) miR-801, (ii) miR-801 and miR-148b, (iii) miR-801 and miR-376c, (iv) miR-801 and miR-409-3p, (v) miR-801, miR-376c and miR-148b, (vi) miR-801, miR-409-3p and miR-376c, (vii) miR-801, miR-409-3p and miR-148b, miR-801, miR-376c, miR-409-3p and miR-148b, (ix) miR-148b, (x) miR-409-3p, (xi) miR-376c, (xii) miR-376c and miR-409-3p, (xiii) miR-148b and miR-376c, (xiv) miR-148b and miR-409-3p, (xv) miR-148b, miR-376c and miR-409-3p, (xvi) miR-127-3p, (xvii) miR-148b, (xvii) miR-376a, (xix) miR-376c, (xx) miR-409-3p, (xxi) miR-652, (xxii) miR-127-3p, miR-148b, miR-376a, miR-376c, miR-409-3p, miR-652, and miR-801, (xxiii) miR-127-3p, miR-148b, miR-652, and miR-801, (xxiv) miR-376a,

Abstract: The present invention is directed to methods for diagnosing breast cancer, metastasizing breast cancer, or for determining the CTC status in a subject. Moreover, the present invention is concerned with devices and kits for carrying methods of the invention. The methods comprise determining in a sample of a subject suspected to be afflicted with breast cancer the amount of at least one miRNA selected from a recited list of miRNAs, followed by comparing the amount with one or more references, whereby breast cancer is to be diagnosed.

Abstract: The present invention relates to a method for the synthesis of double-stranded nucleic acids from a wide variety of samples and comprises the use of these nucleic acids for deep sequence analysis. Also, the present invention relates to specific reagents used in the method of the present invention. Further, the invention relates to kits comprising reagents for the method of the invention and use of said kits.

Abstract: The present invention relates to panels of methylation and mi RNA marker as well as their use in the prognosing, diagnosing and/or treatment of cancer, means for detecting said marker, kits comprising said means, and devices for analysing the marker panel.

Abstract: Provided is a novel method for the early detection and/or discrimination of cancer and anti-cancer agents for the prevention or early treatment of cancer. In particular, the method relates to the determination of levels of circulating miRNAs in breast cancer patients, both primary and metastatic. Furthermore, kits, devices, pharmaceutical compositions as well as methods related thereto are described.

Abstract: The present invention pertains to a new method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of breast cancer in a patient. The method is based on the use of hyaluronic acid and S100P as combined biomarkers in the plasma of breast cancer patients. The new biomarkers of the invention allow diagnosing and even stratifying of breast cancer, in particular metastatic breast cancer. The method provides an interesting alternative to present procedures such as the analysis of the circulating tumor cells (CTC) status. The biomarkers of the invention furthermore allow to monitor therapy success of breast cancer patients and to estimate a patient's prognosis.

Abstract: Provided is a novel method for the early detection and/or discrimination of cancer and anti-cancer agents for the prevention or early treatment of cancer. In particular, the method relates to the determination of levels of circulating miRNAs in breast cancer patients, both primary and metastatic. Furthermore, kits, devices, pharmaceutical compositions as well as methods related thereto are described.

Abstract: The present invention is directed to methods for diagnosing breast cancer, metastasizing breast cancer, or for determining the CTC status in a subject. Moreover, the present invention is concerned with devices and kits for carrying methods of the invention. The methods comprise determining in a sample of a subject suspected to be afflicted with breast cancer the amount of at least one miRNA selected from a recited list of miRNAs, followed by comparing the amount with one or more references, whereby breast cancer is to be diagnosed.