Patents by Inventor Barbara J. Gour

Barbara J. Gour has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for modulating cell adhesion
    Patent number: 6326352
    Abstract: Cyclic peptides and compositions comprising such cyclic peptides are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV. Methods for using such peptides and compositions for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: December 4, 2001
    Assignee: McGill University
    Inventors: Orest W. Blaschuk, Barbara J. Gour
  • Compounds and methods for modulating tissue permeability
    Patent number: 6310177
    Abstract: Methods for using modulating agents to enhance or inhibit occludin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase vasopermeability. The modulating agents comprise at least one occludin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the occludin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: October 30, 2001
    Assignee: Adherex Technologies, Inc.
    Inventors: Orest W. Blaschuk, James Matthew Symonds, Barbara J. Gour
  • Compounds and methods for modulating &bgr;-catenin mediated gene expression
    Patent number: 6303576
    Abstract: Modulating agents for inhibiting &bgr;-catenin mediated gene expression are provided. The modulating agents comprise one or more of: (1) the peptide sequence LXXLL (SEQ ID NO:1); or (2) a peptide analogue or peptidomimetic thereof. Methods for using such modulating agents for modulating &bgr;-catenin mediated gene expression and cellular differentiation in a variety of contexts (e.g., for modulating hair growth or treating cancer or Alzheimer's disease) are provided.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: October 16, 2001
    Assignee: Adherex Technologies Inc.
    Inventors: Orest W. Blaschuk, Stephen Byers, Barbara J. Gour
  • Compounds and methods for modulating adhesion molecule function
    Patent number: 6277824
    Abstract: Modulating agents and methods for enhancing or inhibiting cadherin-mediated functions are provided. The modulating agents comprise at least an HAV binding motif, an analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a motif. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: August 21, 2001
    Assignee: Adherex Technologies
    Inventors: Patrick Doherty, Orest W. Blaschuk, Barbara J. Gour
  • Compounds and methods and modulating tissue permeability
    Patent number: 6248864
    Abstract: Methods for using modulating agents to enhance or inhibit occludin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase vasopermeability. The modulating agents comprise at least one occludin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the occludin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: June 19, 2001
    Assignee: Adherex Technologies, Inc.
    Inventors: Orest W. Blaschuk, James Matthew Symonds, Barbara J. Gour
  • Compounds and methods for modulating neurite outgrowth
    Patent number: 6207639
    Abstract: Modulating agents comprising cyclic peptides, and compositions comprising such modulating agents are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV. Methods for using such peptides and compositions for modulating and/or directing neurite outgrowth in a variety of contexts are also provided.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: March 27, 2001
    Assignee: McGill University
    Inventors: Orest W. Blaschuk, Barbara J. Gour
  • Compounds and methods for regulating cell adhesion
    Patent number: 6203788
    Abstract: Methods for using modulating agents to enhance or inhibit cadherin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. In particular, the modulating agents may be used in the therapy of multiple sclerosis and other demyelinating diseases. The modulating agents comprise at least one cadherin cell adhesion recognition sequence (HAV) or an antibody or fragment thereof that specifically binds to a cadherin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: March 20, 2001
    Assignee: Adherex Inc.
    Inventors: Orest W. Blaschuk, Barbara J. Gour
  • Compounds and methods for modulating cell adhesion
    Patent number: 6169071
    Abstract: Cyclic peptides and compositions comprising such cyclic peptides are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV. Methods for using such peptides and compositions for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: January 2, 2001
    Assignee: McGill University
    Inventors: Orest W. Blaschuk, Barbara J. Gour
  • Compounds and methods for modulating tissue permeability
    Patent number: 6110747
    Abstract: Methods for using modulating agents to enhance or inhibit occludin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. Within certain embodiments, the modulating agents may be used to increase vasopermeability. The modulating agents comprise at least one occludin cell adhesion recognition sequence or an antibody or fragment thereof that specifically binds the occludin cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: August 29, 2000
    Assignee: Adherex Technologies Inc.
    Inventors: Orest W. Blaschuk, James Matthew Symonds, Barbara J. Gour
  • Compounds and methods for modulating cell adhesion
    Patent number: 6031072
    Abstract: Cyclic peptides and compositions comprising such cyclic peptides are provided. The cyclic peptides comprise a cadherin cell adhesion recognition sequence HAV. Methods for using such peptides and compositions for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: February 29, 2000
    Assignee: McGill University
    Inventors: Orest W. Blaschuk, Barbara J. Gour