Patents by Inventor Barbara Olszewska-Pazdrak

Barbara Olszewska-Pazdrak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative
    Patent number: 8334259
    Abstract: Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: December 18, 2012
    Assignees: The Board of Regents, The University of Texas System, The Texas A&M University System
    Inventors: Darrell H. Carney, Barbara Olszewska-Pazdrak, Theresa W. Fossum
  • THROMBIN DERIVED PEPTIDES FOR SMOOTH MUSCLE RELAXATION
    Publication number: 20110117075
    Abstract: Agonists of a non-proteolytically activated thrombin receptor, and more particularly, thrombin peptide derivatives, can be used in methods to cause smooth muscle relaxation. Compositions comprising thrombin peptide derivatives can be administered to a subject with a disease or disorder that can be ameliorated by relaxation of smooth muscle. Such compositions can also be administered to a subject to facilitate medical, diagnostic or surgical procedures.
    Type: Application
    Filed: March 24, 2009
    Publication date: May 19, 2011
    Inventors: Darrell H. Carney, Barbara Olszewska-Pazdrak, Theresa W. Fossum
  • METHOD OF TREATING PERIPHERAL ARTERIAL DISEASE
    Publication number: 20110110920
    Abstract: An agonist of a non-proteolytically activated thrombin receptor can be used in a method for treating peripheral arterial disease. The agonist can be a thrombin peptide derivative. In some embodiments, the peripheral arterial disease is characterized by intermittent claudication. The thrombin peptide derivatives to be used in the methods can have amino acid sequences similar to a region of thrombin. Usually, the thrombin peptide derivatives are 12-23 amino acid residues in length. In some cases, the thrombin peptide derivatives are dimers, and in particular, dimers that result from formation of a disulfide bond between two cysteine residues of peptide monomers.
    Type: Application
    Filed: March 24, 2009
    Publication date: May 12, 2011
    Inventors: Darrell H. Carney, Barbara Olszewska-Pazdrak, Theresa W. Fossum
  • COMBINATION THERAPY FOR CHRONIC DERMAL ULCERS
    Publication number: 20100330028
    Abstract: Disclosed is a method of promoting healing of a chronic dermal ulcer, such as a diabetic ulcer, in a subject. The method comprises administering to the subject a combination one or more agonists of the non-proteolytically activated thrombin receptor and one or more angiogenic growth factors.
    Type: Application
    Filed: April 10, 2008
    Publication date: December 30, 2010
    Inventors: Barbara Olszewska-Pazdrak, Darrell H. Carney
  • COMBINATION THERAPY FOR CARDIAC REVASCULARIZATION AND CARDIAC REPAIR
    Publication number: 20100303793
    Abstract: An agonist of the non-proteolytically activated thrombin receptor and an angiogenic growth factor can be used in combination in methods of therapy to stimulate cardiac revascularization, to stimulate vascular endothelial cell proliferation, to stimulate vascular endothelial cell migration and to promote repair of cardiac tissue.
    Type: Application
    Filed: April 10, 2008
    Publication date: December 2, 2010
    Inventors: Barbara Olszewska-Pazdrak, Darrell H. Carney
  • Method of treating endothelial dysfunction
    Publication number: 20090304671
    Abstract: Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.
    Type: Application
    Filed: September 21, 2007
    Publication date: December 10, 2009
    Inventors: Darrell H. Carney, Barbara Olszewska-Pazdrak, Theresa W. Fossum