Patents by Inventor Barbara Ramsay Shaw

Barbara Ramsay Shaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of nucleic acid sequencing
    Patent number: 6808897
    Abstract: The present invention relates, in general, to a process of enzymatically synthesizing nucleic acids containing nucleotides that are resistant to degradation. The invention further relates to methods of utilizing such nucleic acids in DNA and RNA amplification and sequencing, gene therapy and molecular detection protocols.
    Type: Grant
    Filed: October 30, 2001
    Date of Patent: October 26, 2004
    Assignee: Duke University
    Inventors: Barbara Ramsay Shaw, Kenneth W. Porter, Dmitri Sergueev
  • Method of nucleic acid sequencing
    Publication number: 20030064483
    Abstract: The present invention relates, in general, to a process of enzymatically synthesizing nucleic acids containing nucleotides that are resistant to degradation. The invention further relates to methods of utilizing such nucleic acids in DNA and RNA amplification and sequencing, gene therapy and molecular detection protocols.
    Type: Application
    Filed: October 30, 2001
    Publication date: April 3, 2003
    Applicant: DUKE UNIVERSITY.
    Inventors: Barbara Ramsay Shaw, Kenneth W. Porter, Dmitri Sergueev
  • Method of nucleic acid sequencing
    Patent number: 6376178
    Abstract: The present invention relates, in general, to a process of enzymatically synthesizing nucleic acids containing nucleotides that are resistant to degradation. The invention further relates to methods of utilizing such nucleic acids in DNA and RNA amplification and sequencing, gene therapy and molecular detection protocols.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: April 23, 2002
    Assignee: Duke University
    Inventors: Barbara Ramsay Shaw, Kenneth W. Porter, Dmitri Sergueev
  • Synthesis of oligonucleotides with boranophosphonate linkages
    Patent number: 5859231
    Abstract: The present invention relates, in general, to a process of enzymatically synthesizing nucleic acids containing boranophosphonate linkages that are resistant to degradation. The invention further relates to methods of utilizing such nucleic acids in DNA and RNA amplification and sequencing, gene therapy and molecular detection protocols.
    Type: Grant
    Filed: September 16, 1996
    Date of Patent: January 12, 1999
    Assignee: Duke University
    Inventors: Barbara Ramsay Shaw, Kenneth W. Porter, Dmitri Sergueev
  • Method of nucleic acid sequencing
    Patent number: 5683869
    Abstract: The present invention relates, in general, to a process of enzymatically synthesizing nucleic acids containing nucleotides that are resistant to degradation. The invention further relates to methods of utilizing such nucleic acids in DNA and RNA amplification and sequencing, gene therapy and molecular detection protocols.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: November 4, 1997
    Assignee: Duke University
    Inventors: Barbara Ramsay Shaw, Kenneth W. Porter
  • Boronated compounds
    Patent number: 5659027
    Abstract: A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds are boronated at the ring nitrogen of the purine or pyrimidine base, or at a 2', 3' or 5' amino substituent of the nucleoside sugar.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: August 19, 1997
    Assignees: University of North Carolina, Boron Biologicals, Inc., Duke University
    Inventors: Bernard F. Spielvogel, Anup Sood, Iris H. Hall, Barbara Ramsay Shaw, Jeno Tomasz
  • Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
    Patent number: 5177198
    Abstract: A process of making oligoribonucleoside and deoxyribonucleoside boranophosphates and salts thereof is disclosed. The process comprises the steps of condensing a ribonucleotide or deoxyribonucleotide with a nucleoside phosphitylating agent, wherein the phosphitylating agent includes a 5' -OH group protected by an acid-labile protecting group and a moiety bonded to the phosphorus atom therein that is a stronger proton acceptor than the 5'-OH group of the ribonucleotide or deoxyribonucleotide to form a reaction intermediate, then oxidizing the reaction intermediate so formed with a compound comprising a Lewis base and a boron-containing substituent, wherein the Lewis base is a weaker electron donor than the phosphite phosphorus of the reaction intermediate, to form a ribonucleotide or deoxyribonucleotide boranophosphate. These steps are repeated on the nucleotide boranophosphate to form an oligonucleotide boranophosphate.
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: January 5, 1993
    Assignees: University of N.C. at Chapel Hill, Duke University, Boron Biologicals, Inc.
    Inventors: Bernard F. Spielvogel, Anup Sood, Iris H. Hall, Barbara Ramsay Shaw
  • Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
    Patent number: 5130302
    Abstract: A novel class of pharmaceutically active boronated nucleosides are provided. The nucleosides are boronated at a ring nitrogen of the purine or pyrimidine or analogues thereof. Also provided are phosphate esters of these nucleosides and oligomers thereof. Methods of making and using the boronated nucleosides are also disclosed.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: July 14, 1992
    Assignee: Boron Bilogicals, Inc.
    Inventors: Bernard F. Spielvogel, Anup Sood, Iris H. Hall, Barbara Ramsay Shaw