Patents by Inventor Barbara Smith
Barbara Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230400412Abstract: The disclosure provides a system, compositions, and methods for detecting ovarian cancer cells by photoacoustic flow cytometry.Type: ApplicationFiled: August 24, 2023Publication date: December 14, 2023Inventors: Barbara Smith, Joel Lusk
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Patent number: 11788965Abstract: The disclosure provides a system, compositions, and methods for detecting ovarian cancer cells by photoacoustic flow cytometry.Type: GrantFiled: February 21, 2020Date of Patent: October 17, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Barbara Smith, Joel Lusk
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Patent number: 11596313Abstract: Photoacoustic targeting systems for intracellular recording. In one embodiment, the photoacoustic targeting system includes a light source, a micropipette electrode, an acoustic transducer, and a controller. The light source is configured to emit pulsed light. The micropipette electrode is configured to deliver the pulsed light to a target cell. The acoustic transducer is configured to receive photoacoustic signals generated due to optical absorption of light energy by the target cell. The controller is configured to determine a position of the micropipette electrode relative to the target cell based on the photoacoustic signals.Type: GrantFiled: October 12, 2018Date of Patent: March 7, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Barbara Smith, Christopher Miranda
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Patent number: 11583252Abstract: A device comprises a miniature transducer having an altered backing geometry that can be placed within different casing sizes of an imaging probe device. The backing geometry extends along a longitudinal axis of the imaging probe and provides an angle (e.g., 45-degree angle) configured to reflect ultrasound and/or light waves/signals in a direction perpendicular to the longitudinal axis of the imaging probe. This design is configured to enable ultrasound and/or light waves/signals to be redirected and dampened within the transducer to preserve a suitable signal to noise ratio while minimizing the required depth of the backing.Type: GrantFiled: August 9, 2018Date of Patent: February 21, 2023Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Barbara Smith, Christopher Miranda
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Publication number: 20220331803Abstract: A collection device for collecting volatile organic compounds (VOCs) from a living biological sample is disclosed. The collection device comprises a housing defining an interior chamber and an inlet and outlet each fluidly communicating with the interior chamber. The housing is formed by an upper surface, a lower surface, and a substantially circular sidewall extending between the upper and lower surfaces. The interior chamber comprises a substantially cylindrical volume enclosed by the housing and configured to receive the living biological sample. The inlet and the outlet may extend through the upper surface and may be substantially diametrically opposed with respect to the circular sidewall. The collection device may be configured to pass fluid in a substantially laminar flow path through the inlet, across the interior chamber, and out of the outlet. At least a portion of the housing may comprise a substantially transparent material configured to transmit light therethrough.Type: ApplicationFiled: April 7, 2022Publication date: October 20, 2022Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Barbara Smith, Jarrett Eshima, Joel Lusk, Benjamin Ambrose
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Publication number: 20220160236Abstract: A system for calculating a Grüneisen parameter of a target tissue is disclosed. The system comprises a first light source configured to emit a first light signal to the target tissue, thereby generating an acoustic signal in the target tissue. The system further comprises a second light source configured to emit a second light signal to the target tissue, which interacts with the acoustic signal, (e.g., in the manner of Brillouin scattering) to generate a backscattered light signal. The system further comprise a light sensor configured to detect the backscattered light signal and a processor configured to receive the backscattered light signal from the light sensor and calculate the Grüneisen parameter of the target tissue based on the backscattered response signal.Type: ApplicationFiled: November 23, 2021Publication date: May 26, 2022Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Barbara SMITH, Christopher MIRANDA
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Publication number: 20220160289Abstract: A system for measuring a membrane potential is disclosed. The system comprises a photoacoustic probe including a laser and an ultrasound transducer. The laser is configured to emit a light signal at one or more wavelengths to a neuronal cell. The neuronal cell may comprise a voltage-sensitive protein configured to absorb the light signal in a voltage-dependent manner. The ultrasound transducer is configured to receive a photoacoustic signal from the voltage-sensitive protein in response to absorbing the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer and calculate a membrane potential of the neuron based on the photoacoustic signal. Methods of measuring a membrane potential and biomaterials related to the voltage-sensitive protein are also disclosed herein.Type: ApplicationFiled: November 23, 2021Publication date: May 26, 2022Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Barbara SMITH, Christopher MIRANDA
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Publication number: 20210353782Abstract: A system for measuring the membrane potential of a neuron is disclosed. The system comprises one or more photoacoustic ion indicators, each comprising a metal chelating agent linked to a chromophore molecule. The metal chelating agent is configured to selectively bind to one of sodium ions, calcium ions, and potassium ions. The system further comprises a photoacoustic probe including a laser configured to emit a light signal to the chromophore and an ultrasound transducer configured to receive a photoacoustic signal in response to the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer, determine a quantity of photoacoustic ion indicators exhibiting the shift, and calculate a membrane potential of the neuron based on quantity of photoacoustic ion indicators exhibiting the shift.Type: ApplicationFiled: May 17, 2021Publication date: November 18, 2021Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Barbara SMITH, Christopher MIRANDA, Madeleine HOWELL, Joel LUSK
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Publication number: 20210275140Abstract: A device comprises a cannula having a first end, a second end, and a channel between the first end and the second end; an imaging probe couplable to the first end of the cannula, where the imaging probe includes: a transducer, and a reflective surface; and a biopsy device coupled to the cannula, where the biopsy device is configured to collect a tissue sample from an organ of a patient.Type: ApplicationFiled: May 25, 2021Publication date: September 9, 2021Inventors: Barbara SMITH, Joel BARKLEY, Christopher MIRANDA
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Patent number: 11045169Abstract: A device comprises a cannula having a first end, a second end, and a channel between the first end and the second end; an imaging probe couplable to the first end of the cannula, where the imaging probe includes: a transducer, and a reflective surface; and a biopsy device coupled to the cannula, where the biopsy device is configured to collect a tissue sample from an organ of a patient.Type: GrantFiled: June 23, 2017Date of Patent: June 29, 2021Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Barbara Smith, Joel Barkley, Christopher Miranda
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Publication number: 20200360032Abstract: An extractor device including a handle, a grasper, a catheter, a control ring, and a control fiber is disclosed. The handle has a drive slide that moves the grasper in and out of the catheter. The grasper has a plurality of arms of staggered length, each slideably coupled to the control fiber to form a control fiber loop while the grasper is outside the catheter Pulling the control ring constricts the loop, deflecting the ends of the arms inward and bending the arms around a foreign body.Type: ApplicationFiled: December 1, 2018Publication date: November 19, 2020Inventors: Barbara Smith, Erik Drager, Christopher Pina, Krystal Schmitt, Justin Blommer
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Publication number: 20200271655Abstract: The disclosure provides a system, compositions, and methods for detecting ovarian cancer cells by photoacoustic flow cytometry.Type: ApplicationFiled: February 21, 2020Publication date: August 27, 2020Inventors: Barbara Smith, Joel Lusk
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Publication number: 20190282069Abstract: Methods and systems for image-based guidance in deep-brain stimulation. An endoscope system includes a waveguide tube, a right-angle prism, a light source, and a photoacoustic transducer. Light from the light source propagates along the length of the waveguide tube via internal reflection within the wall. The right-angle prism is positioned to redirect light emitted at a distal end of the waveguide tube in a direction perpendicular to the length of the waveguide tube. Light emitted in the perpendicular direction causes soundwaves to be generated by the surrounding tissue via photoacoustic effect. Those soundwaves are then conducted through the interior channel of the waveguide tube from the distal end of the waveguide tube to a proximal end of the waveguide tube where the soundwaves are detected by the photoacoustic transducer, which is acoustically coupled to the interior channel of the waveguide tube at the proximal end of the waveguide tube.Type: ApplicationFiled: March 18, 2019Publication date: September 19, 2019Inventors: Barbara Smith, Christopher Miranda
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Publication number: 20190110691Abstract: Photoacoustic targeting systems for intracellular recording. In one embodiment, the photoacoustic targeting system includes a light source, a micropipette electrode, an acoustic transducer, and a controller. The light source is configured to emit pulsed light. The micropipette electrode is configured to deliver the pulsed light to a target cell. The acoustic transducer is configured to receive photoacoustic signals generated due to optical absorption of light energy by the target cell. The controller is configured to determine a position of the micropipette electrode relative to the target cell based on the photoacoustic signals.Type: ApplicationFiled: October 12, 2018Publication date: April 18, 2019Inventors: Barbara Smith, Christopher Miranda
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Publication number: 20190046159Abstract: A device comprises a miniature transducer having an altered backing geometry that can be placed within different casing sizes of an imaging probe device. The backing geometry extends along a longitudinal axis of the imaging probe and provides an angle (e.g., 45-degree angle) configured to reflect ultrasound and/or light waves/signals in a direction perpendicular to the longitudinal axis of the imaging probe. This design is configured to enable ultrasound and/or light waves/signals to be redirected and dampened within the transducer to preserve a suitable signal to noise ratio while minimizing the required depth of the backing.Type: ApplicationFiled: August 9, 2018Publication date: February 14, 2019Inventors: Barbara Smith, Christopher Miranda
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Publication number: 20170367682Abstract: A device comprises a cannula having a first end, a second end, and a channel between the first end and the second end; an imaging probe couplable to the first end of the cannula, where the imaging probe includes: a transducer, and a reflective surface; and a biopsy device coupled to the cannula, where the biopsy device is configured to collect a tissue sample from an organ of a patient.Type: ApplicationFiled: June 23, 2017Publication date: December 28, 2017Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Barbara SMITH, Joel BARKLEY, Christopher MIRANDA
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Patent number: 9497122Abstract: Implementations described and claimed herein providing systems and methods for modeling and visualizing interconnection relationships between a first provider network and a partner. In one implementation, a partner of a provider network is defined by at least one interconnection point where network traffic may be exchanged between the provider network and the partner. An interconnection relationship is generated based on the at least one interconnection point. The interconnection relationship is modeled.Type: GrantFiled: June 7, 2013Date of Patent: November 15, 2016Assignee: Level 3 Communications, LLCInventors: Barbara Smith, Erik Sear, David R. Siegel, Jonathan Callahan, John Kane, Mark Taylor
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Publication number: 20150052773Abstract: A portable hands free hair dryer that gently dries the hair of a user The hair dyer comprises a flexible bonnet having heating coils disposed within, a fan blowing unit, and an air hose connecting the two. When the device is powered on, the heating coils warm the area around the user's hair and scalp, and the fan blows air up through the air hose into the bonnet. Warm air in the bonnet is blown around, drying the user's hair. The fan unit is a small portable unit that can be clipped to a user's clothing, and may be used while cordless or plugged into a wall socket. In either manner of use, the device dries the user's hair without the need for user participation.Type: ApplicationFiled: August 20, 2013Publication date: February 26, 2015Inventors: Amelia Thomas, Barbara Smith
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Patent number: 8706862Abstract: Methods and apparatus for performing non-intrusive data link layer performance measurement in communication networks are disclosed. An example method to measure data link layer performance between existing network nodes disclosed herein comprises coupling a first intelligent network interface (INI) to an available access port of a first existing network node providing access to a network, wherein the first INI obtains power and input information only from the access port after being coupled thereto, and exchanging test messages between the first INI and a second INI coupled to a second existing network node during normal operation of the first and second existing network nodes to measure data link layer performance, wherein the test messages originate in the first INI and are routed through the first and second existing network nodes using a first data link layer address associated with the first INI and a second data link layer address associated with the second INI.Type: GrantFiled: December 21, 2007Date of Patent: April 22, 2014Assignee: AT&T Intellectual Property I, L.P.Inventors: Jonathan Roll, Barbara Smith, Joel Freeman
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Publication number: 20140065922Abstract: This is a toy that involves weaving thin plastic strips through notches in a variety of fun shapes. It is designed for young children to develop finger dexterity as they manipulate the plastic strips to go in and out of the notches. The shapes vary in size, color, theme and complexity. Toy difficulty is graded by the number and sizes of notches and number of sides each strip has. The easiest toys designed for younger children have larger, less notches and simple strips. The more complex shapes have smaller and more notches and use strips that may have 2 or more sides or complex curves. In addition, some shapes and corresponding strips have holes so that after the strips are woven and aligned they can be laced with string. The types and themes of shapes that are woven with one or more strips are limitless.Type: ApplicationFiled: September 3, 2012Publication date: March 6, 2014Inventor: Barbara A. Smith