Patents by Inventor Barbara Wold

Barbara Wold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICROFLUIDIC CHAOTIC MIXING SYSTEMS AND METHODS
    Publication number: 20070054293
    Abstract: Microfluidic nucleic acid hybridization systems are described that include a first reaction chamber to hold an analyte solution comprising nucleic acids, and a first mixing channel in fluid communication with the chamber. The mixing channel includes a textured surface to mix the analyte solution. The systems may also include pump coupled to the mixing channel to circulate the analyte solution through the reaction chamber and the mixing channel, and an input port in fluid communication with the mixing channel and the reaction chamber to supply the analyte solution to the microfluidic system. The input port can be closed to create a closed circulation path for the analyte solution through the reaction chamber and the mixing channel.
    Type: Application
    Filed: August 30, 2006
    Publication date: March 8, 2007
    Applicant: California Institute of Technology
    Inventors: Jian Liu, Brian Williams, Barbara Wold, Stephen Quake
  • Low oxygen culturing of neural crest stem cells and methods of use
    Patent number: 6759242
    Abstract: The present invention relates to the growth of cells in culture under conditions that promote differentiation, cell survival, and/or cellular proliferation. More particularly, culturing neural crest stem cells in low oxygen conditions is described.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: July 6, 2004
    Assignee: California Institute of Technology
    Inventors: Marie Csete, Sean J. Morrison, Barbara Wold, David J. Anderson
  • Methods for isolation and activation of, and control of differentiation from, stem and progenitor cells
    Patent number: 6589728
    Abstract: The present invention provides a method of isolating, maintaining, and/or enriching for stem or progenitor cells derived from diverse organ or tissue sources. The invention specifically teaches that these can be accomplished by the controlled use of subatmospheric oxygen culture, and that the precise oxygen level or levels must be determined empirically and/or by reference to physiologic levels within intact functioning organ or tissue.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: July 8, 2003
    Assignee: California Institute Of Technology
    Inventors: Marie Csete, John Doyle, Barbara Wold
  • Methods for isolation and activation of, and control of differentiation from, stem and progenitor cells
    Publication number: 20010034061
    Abstract: The present invention provides a method of isolating, maintaining, and/or enriching for stem or progenitor cells derived from diverse organ or tissue sources. The invention specifically teaches that these can be accomplished by the controlled use of subatmospheric oxygen culture, and that the precise oxygen level or levels must be determined empirically and/or by reference to physiologic levels within intact functioning organ or tissue.
    Type: Application
    Filed: January 31, 2001
    Publication date: October 25, 2001
    Applicant: California Institute of Technology
    Inventors: Marie Csete, John Doyle, Barbara Wold
  • Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
    Patent number: 6184035
    Abstract: The present invention provides a method of isolating, maintaining, and/or enriching for stem or progenitor cells derived from diverse organ or tissue sources. The invention specifically teaches that these can be accomplished by the controlled use of subatmospheric oxygen culture, and that the precise oxygen level or levels must be determined empirically and/or by reference to physiologic levels within intact functioning organ or tissue. In particular, culturing skeletal muscle progenitor cells in less than 12% oxygen conditions or under 1% oxygen level.
    Type: Grant
    Filed: November 18, 1998
    Date of Patent: February 6, 2001
    Assignee: California Institute of Technology
    Inventors: Marie Csete, John Doyle, Barbara Wold