Patents by Inventor Barney J. Magerlein
Barney J. Magerlein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4837318Abstract: This invention concerns 2-oxoazetidine analogs (monobactams) having antimicrobial activity, novel processes and novel intermediates useful to make monobactams. The compounds of this invention include compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R.sub.1 is an acyl group derived from a carboxylic acid;A is either sulfo, phosphono or a trisubstituted silyl group substituted with (C.sub.1 -C.sub.4) alkyls or phenyl;R.sub.2 is selected from the group consisting of a. (C.sub.1 -C.sub.8) alkyl; b. (C.sub.2 -C.sub.8) alkenyl; c. (C.sub.3 -C.sub.8) alkynyl; d. (C.sub.3 -C.sub.8) cycloalkyl; e. (C.sub.6 -C.sub.8) aryl; f. (C.sub.6 -C.sub.12) aralkyl; g. heterocyclic radicals, where each member of (a) through (g) may be substituted by 1 to 4 substituents selected from group consisting of methoxy, hydroxy, halogen, nitro, and --N(R.sub.10)(R.sub.11) wherein R.sub.10 is hydrogen or alkyl (C.sub.1 -C.sub.4) and R.sub.11 is hydrogen, alkyl (C.sub.1 -C.sub.4) or alkoxy (C.sub.Type: GrantFiled: February 6, 1987Date of Patent: June 6, 1989Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4588817Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.Type: GrantFiled: June 4, 1984Date of Patent: May 13, 1986Assignee: The Upjohn CompanyInventors: Barney J. Magerlein, Howard A. Whaley
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Patent number: 4461903Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.Type: GrantFiled: June 15, 1981Date of Patent: July 24, 1984Assignee: The Upjohn CompanyInventors: Barney J. Magerlein, Howard A. Whaley
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Patent number: 4448970Abstract: Novel antibacterially-active analogs of the antibiotics nodusmicin and nargenicin A.sub.1. These compounds are prepared by selectively blocking active hydroxyl groups at the 9, 11 and 18 positions of nodusmicin, and the 11 and 18 positions of nargenicin A.sub.1. Antibacterially-active compounds can be used in various environments to control or eradicate susceptible bacteria. The techniques for such use are well known in the art.Type: GrantFiled: May 4, 1981Date of Patent: May 15, 1984Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4363922Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.Type: GrantFiled: June 15, 1981Date of Patent: December 14, 1982Assignee: The Upjohn CompanyInventors: Barney J. Magerlein, Howard A. Whaley
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Patent number: 4360683Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.Type: GrantFiled: August 6, 1980Date of Patent: November 23, 1982Assignee: The Upjohn CompanyInventors: Barney J. Magerlein, Howard A. Whaley
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Patent number: 4252970Abstract: 6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-0-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.Type: GrantFiled: March 5, 1979Date of Patent: February 24, 1981Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4232148Abstract: 6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-0-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.Type: GrantFiled: March 5, 1979Date of Patent: November 4, 1980Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4212985Abstract: The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.alpha., PGF.sub.2.beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxyl-terminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenoxy or substituted phenoxy group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.Type: GrantFiled: April 28, 1978Date of Patent: July 15, 1980Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4212811Abstract: Bicyclic lactone intermediates useful for preparing prostaglandin E.sub.2 -type, F.sub.2 -type, A.sub.2 -type, and B.sub.2 -type compounds with one or two methyl or ethyl substituents at the C-16 position are disclosed. These prostaglandin-type compounds are useful for the same pharmacological purposes as the corresponding prostaglandins.Type: GrantFiled: March 6, 1975Date of Patent: July 15, 1980Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4169197Abstract: 6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-O-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.Type: GrantFiled: March 13, 1978Date of Patent: September 25, 1979Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4138574Abstract: The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.alpha., PGF.sub.2.beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxyl-terminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenoxy or substituted phenoxy group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.Type: GrantFiled: April 28, 1978Date of Patent: February 6, 1979Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4065628Abstract: The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.alpha., PGF.sub.2.beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxyl-terminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenyl or substituted phenyl group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.Type: GrantFiled: November 12, 1976Date of Patent: December 27, 1977Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4065629Abstract: The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.alpha., PGF.sub.2.beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxyl-terminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenyl or substituted phenyl group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.Type: GrantFiled: November 12, 1976Date of Patent: December 27, 1977Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4065631Abstract: The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.alpha., PGF.sub.2.beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxyl-terminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenyl or substituted phenyl group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.Type: GrantFiled: November 12, 1976Date of Patent: December 27, 1977Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4063026Abstract: This invention is a group of 4,5-didehydro PG.sub.1 (prostaglandin-type) analogs having variable chain length, branching and fluoro substitution in the hydroxy-substituted side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.Type: GrantFiled: November 7, 1975Date of Patent: December 13, 1977Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4041066Abstract: This invention is a group of 4,5-didehydro and 4,5,17,18-tetrahydro PG.sub.1 (prostaglandin-type) compounds, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.Type: GrantFiled: September 9, 1975Date of Patent: August 9, 1977Assignee: The Upjohn CompanyInventors: Bengt Samuelsson, Barney J. Magerlein
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Patent number: 4038478Abstract: 6-O- and 3'-O-D-glycosyl analogs of neamine, 6-O- and 3'-O-D-glycosyl ortho esters of neamine, novel aminoglycoside antibiotics, and novel intermediates are prepared by a new chemical process. The compounds have utility as antibacterial agents or as intermediates to make antibacterially-active compounds.Type: GrantFiled: June 16, 1976Date of Patent: July 26, 1977Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4032561Abstract: The disclosure includes novel compounds which differ from the known prostaglandins PGF.sub.2.sub..alpha., PGF.sub.2.sup..beta., PGE.sub.2, PGA.sub.2, and PGB.sub.2 in that the carbon-carbon double bond in the carboxylterminated chain of the novel compounds is in the 4,5-position rather than in the 5,6-position, and in that there is a phenyl or substituted phenyl group in the other chain of the novel compounds. These novel compounds are useful for a variety of pharmacological purposes, including abortion, labor induction, and reduction of gastric secretion.Type: GrantFiled: May 27, 1975Date of Patent: June 28, 1977Assignee: The Upjohn CompanyInventor: Barney J. Magerlein
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Patent number: 4031081Abstract: Prostaglandin-type compounds with one or two fluoro substituents at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.Type: GrantFiled: February 21, 1975Date of Patent: June 21, 1977Assignee: The Upjohn CompanyInventor: Barney J. Magerlein