Abstract: This invention discloses an antibody which is raised to a peptide, the sequence of which is: N-R-N-G-K-E-T-K-S-N-Y-R-V-R-V-Y-Q-I-P, N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-P, S-R-N-G-K-E-T-K-S-N-Y-R-V-Q-V-Y-Q-I-P, N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-C, or Ac-N-R-R-G-K-E-V-K-S-N-Y-R-V-R-V-Y-Q-I-C-amide. This antibody can be labeled with an imageable marker or linked to an agent. This antibody can be a monoclonal antibody. The invention also includes a method for determining the location of receptor advanced glycation endproduct (RAGE) in a subject comprising administering the antibody labeled with an imageable marker and detecting the location of the labeled antibody in the subject thereby determining the location of RAGE in the subject. This invention further describes a method for treating a RAGE-related disorder in a subject comprising administering to the subject a therapeutically effective amount of the antibody which binds to the above-described epitope linked to an agent.

Abstract: An improved seal for a tamper evident security device employs out-of-plane curved barbs and an elongated slot to provide visual and tactile indications of proper seal installation. The out-of-plane curved barbs require elevating the seal body for installation. Only if the barbs are properly inserted into a seal receptacle does the body then assume a flat contiguous position. The elongated slot cooperates with a raised bar on the security device to provide a second distinct indication of proper seal installation.

Abstract: This invention provides a polypeptide consisting essentially of all or a portion of the cytoplasmic domain of RAGE. This invention further provides a polypeptide consisting essentially of a portion of Diaphanous that binds to the cytoplasmic domain of RAGE. Additionally, this invention provides related nucleic acids, vectors, cells and methods.

Abstract: A padlock is provided with a disposable seal indicating whether the padlock has been opened. The seal can be provided with indicia identifying the last entity to seal the padlock, and so is useful for luggage security during travel.

Abstract: A rotary engine (2) comprises a housing (16) having a male rotor (4) having a plurality of projecting lobes (12) and a female rotor (8) having a plurality of cavities (14). The male (4) and female rotors (8) are mounted for synchronous rotation about parallel axes such that during rotation successive lobes (12) on the male rotor (4) mate with successive cavities (14) on the female rotor (8) to define therewith a combustion chamber (26) in which a mixture of air and fuel is compressed by the interaction of the lobe (12) and the cavity (14) during rotor rotation. At least one exhaust port (78, 80) leads out of the housing (16) for discharge of exhaust gases from the cavity (14) of the female rotor (8) following combustion and from the space (74) between adjacent lobes (12) of the male rotor (4) following combustion.

Abstract: An improved seal for a tamper evident security device employs out-of-plane curved barbs and an elongated slot to provide visual and tactile indications of proper seal installation. The out-of-plane curved barbs require elevating the seal body for installation. Only if the barbs are properly inserted into a seal receptacle does the body then assume a flat contiguous position. The elongated slot cooperates with a raised bar on the security device to provide a second distinct indication of proper seal installation.

Abstract: A security device for a slide fastener, including a housing adapted to be fitted to an object to which the slide fastener is attached, the housing substantially surrounding the slider of the slide fastener in its fully closed position, a closure member adapted to cooperate with the housing which, in use, covers the slider to prevent access thereto and a frangible locking element adapted to link the housing to the closure member, the locking element being resiliently yieldable and slidably insertable into the closure member but not retractable therefrom without fracturing the frangible locking element. The closure member is attached at one end to a puller and the puller is attached to the slider. In a preferred embodiment the closure member can pivot about the housing and block withdrawal of the slider from the housing in its closed position.

Abstract: A security device for a slide fastener, the security device including a housing adapted to be fitted to an object to which the slide fastener is attached, the housing substantially surrounding the slider of the slide fastener in its fully closed position, a closure member adapted to co-operate with the housing which, in use, covers the slider to prevent access thereto and a frangible locking element adapted to link the housing to the closure member, the locking element being resiliently yieldable and slidably insertable into the closure member but not retractable therefrom without fracturing the frangible locking element. Preferably the closure member is attached at one end to a puller and the puller is attached to the slider. In a preferred embodiment the closure member can pivot about the housing and block withdrawal of the slider from the housing in its closed position.

Abstract: This invention relates to an improved process for the production of hydroxyketones, especially dihydroxyacetone, by the condensation of one or more aldehydes in the presence of a catalyst and the use of specific process train. The product of this process is a relatively pure and any waste products from the reaction are environmentally friendly because none of the chemical components are discharged into the waste streams.

Abstract: This invention relates to a process for synthesis of glycerol from formaldehyde, wherein formaldehyde under substantially anhydrous condition is self-condensed in a catalytic step is dihydroxyacetone which is separated from the self-condensation catalyst and hydrogenated catalytically to glycerol.The feature of the invention is to have less than 0.4% w/w of water in the self-condensation reaction mixture thereby improving the process to produce glycerol in commercially viable rates and yields.

Abstract: This invention relates to an integrated process for producing polycarbonates by transesterification of a dialkyl carbonate with a bisphenol diester to form a carbonate oligomer and an alkyl ester followed by polymerization of the oligomer to a polycarbonate. The feature of the invention lies in the carbonylation of the alkyl ester by-product formed during the transesterification step to an ahydride which is used to esterify bisphenol to the diester.

Abstract: This invention relates to esters of alkyl diglycol ethers with mono- and dicarboxylic acids and the use thereof as coalescing agents in polymer latices employed in paint formulations. A particularly preferred ester is ethyldiglycol propionate. The esters claimed are effective in lowering the minimum film forming temperature of various emulsion polymers, are stable in the presence of water and are compatible with pigments and fillers normally used in paint formulations.

Abstract: A process for the liquid phase oxidation of hydrocarbons with a molecular oxygen-containing gas in the presence of a dissolved cobalt salt catalyst characterized in that the oxidation is carried out in the substantial absence of chromium in the reaction medium i.e. a concentration of chromium in the liquid phase of not greater than 400 ppm.

Abstract: In a process for the production of oxygenated organic compounds including a substantial proportion of acetic acid by oxidizing a C.sub.3 to C.sub.7 saturated aliphatic hydrocarbon in the liquid phase with molecular oxygen in the presence of an inert reaction medium and a cobalt catalyst, between 5 and 90% in a continuous reaction and 11 and 90% in a batch reaction of the cobalt being introduced in the +3 oxidation state, the improvement comprising separating the catalyst solution fraction from the fraction comprising oxygen-containing compounds and water by distillation while limiting the residence time of the catalyst solution fraction in the distillation zone so that it is the minimum consistent with substantially complete separation of the fractions thereby minimizing the reduction of Co.sup.+3 to Co.sup.+2.

Abstract: A process for the production of oxygenated organic compounds including a substantial proportion of acetic acid by oxidizing a C.sub.3 to C.sub.7 saturated aliphatic hydrocarbon in the liquid phase with molecular oxygen in the presence of an inert reaction medium and a cobalt catalyst, between 5 and 90% in a continuous reaction and 11 and 90% in a batch reaction of the cobalt being introduced in the +3 oxidation state. The process is particularly applicable to the embodiment wherein the catalyst solution is recycled to the oxidation reaction. In order to achieve this a low-residue time distillation unit is preferably employed.