Abstract: A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.

Abstract: A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.

Abstract: A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.

Abstract: A pharmaceutical dosage form which comprises a lactide, glycolide or lactide-glycolide polymer, a block polymer of polyglycolide, trimethylene carbonate, poly-caprolactone, and polyethylene oxide that is combined with a peptide or protein therapeutic agent in the form of microparticles which are compressed using a pressure of 50,000 to 350,000 psi.

Abstract: A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.

Abstract: A pharmaceutical dosage form which comprises a lactide, glycolide or lactide-glycolide polymer, a block polymer of polyglycolide, trimethylene carbonate, poly-caprolactone, and polyethylene oxide that is combined with a peptide or protein therapeutic agent in the form of microparticles which are compressed using a pressure of 50,000 to 350,000 psi.

Abstract: A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle or nanoparticle which is “hyper-compressed” to form a controlled release dispensing device and methods of locally administering a therapeutic agent using said microparticles.

Abstract: A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle or nanoparticle which is “hyper-compressed” to form a controlled release dispensing device and methods of locally administering a therapeutic agent using said microparticles.

Abstract: A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle or nanoparticle which is “hyper-compressed” to form a controlled release dispensing device and methods of locally administering a therapeutic agent using said microparticles.

Abstract: A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle which is compressed to form a controlled release dispensing device and methods of locally administering a therapeutic agent using said microparticles.

Abstract: An ophthalmic dispensing device having a polymer which is combined with an ophthalmic therapeutic agent in the form of a microparticle which is hypercompressed to form a controlled release dispensing device for ophthalmic use.

Abstract: A method of treating mucositis, herpetic infections or fungal infections by contacting the affected area with an amount of composition which comprises triclosan or a combination of triclosan and a cationic antibacterial compound in an amount which is effective to alleviate the symptoms of the particular condition.

Abstract: A method of preventing mucositis of mucosal tissues in patients is disclosed which is based on contacting the affected area with an amount of composition which comprises triclosan in amounts which are effective to prevent the symptoms of mucositis.

Abstract: A method of preventing mucositis of mucosal tissues in patients is disclosed which is based on contacting the affected area with an amount of composition which comprises triclosan in amounts which are effective to prevent the symptoms of mucositis.

Abstract: A water based composition having triclosan in an amount of 0.01 to 3% by weight in combination with from 5-35% by weight of a non-toxic polyhydric alcohol and from 0.5-5% by weight of a poloxamer.

Abstract: An antiplaque mouth rinse conducive to oral hygiene. The mouth rinse composition includes a water-alcohol vehicle having dissolved therein two antibacterial agents that coact to promote the delivery of these agents and their retention on the teeth and soft tissue in the dental region of the oral cavity of the user, thereby inhibiting the formation of plaque. One agent, Triclosan, is water-insoluble and noncationic, a solubilizer therefor being included in the composition. The other agent, cetyl pyridinium chloride (CPC) is soluble in water and alcohol and is cationic. When the combination of Triclosan and CPC is delivered to the dental region, it is adsorbed and retained thereby to afford enhanced antibacterial activity.

Abstract: A composition for treating diseased tissues resulting from a herpes simplex virus infection. When in ointment form, the composition has dispersed in an oil and water emulsion two distinct antimicrobial agents, one being Triclosan which is non-cationic and water insoluble, the Triclosan being solubilized by a solubilizer. The second antimicrobial agent which is cationic and water-soluble, is combined with the solubilized Triclosan to produce an antimicrobial composite that is polar and retained by the diseased tissues to which it is applied.

Abstract: An alkaline oral hygiene composition which when brushed or otherwise applied to surfaces of the teeth and adjacent gingival tissue functions not only to clean and whiten the teeth but also to prevent the formation of plaque, to neutralize acids causing tooth decay and to remove from the surfaces extraneous material which discolor the teeth. Included in the composition is at least one alkaline metal compound powder having minimal abrasivity which imparts to the composition an overall pH in excess of 9 whereby when used in the acidic environment of the oral cavity, retains its alkalinity to counteract the activity of pathogenic bacteria causing plaque and to neutralize the production in the oral cavity of acids causing tooth decay. The alkaline composition also saponifies foreign material attached to the teeth surfaces so that these materials which discolor the teeth can be washed away.

Abstract: An intraoral appliance which when worn by a singer or other vocalist acts to improve the quality of the voice and increase its power. The appliance is constituted by a pair of spacer pieces molded to conform to select teeth in the oral cavity of the vocalist, the pieces being seated on molars or other teeth on opposing sides of either the upper or the lower dental arch. The smooth head surfaces of the pieces are raised slightly above the teeth on which they are seated to prevent the arches from meeting and causing the mandible supporting the lower arch to slide forward relative to the maxilla to an extent limited by the parameters of the temporomadibular joint. The displaced mandible serves to release tension on the muscles of the head, neck and chest associated with the mandible, giving rise to greater and more efficient respiration, a relaxation of the hyoid bone supporting the tongue and its muscles and from which the larynx is suspended, and a relaxation of the vocal cords of the larynx.

Abstract: An antiplaque mouth rinse conducive to oral hygiene. The mouth rinse composition includes a water-alcohol vehicle having dissolved therein two antibacterial agents that coact to promote the delivery of these agents and their retention on the teeth and soft tissue in the dental region of the oral cavity of the user, thereby inhibiting the formation of plaque. One agent, Triclosan, is water-insoluble and noncationic, a solubilizer therefor being included in the composition. The other agent, cetyl pyridinium chloride (CPC) is soluble in water and alcohol and is cationic. When the combination of Triclosan and CPC is delivered to the dental region, it is adsorbed and retained thereby to afford enhanced antibacterial activity.