Patents by Inventor Barry Merriman
Barry Merriman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132952Abstract: A method of genotyping includes applying a sample solution including a plurality of copies of a sample polynucleotide to an array of sensors. The sample polynucleotide includes a region associated with an allele. The method further includes measuring using a plurality of sensors of the array of sensors a characteristic of the region of the plurality of copies of the sample polynucleotide and determining using a computational circuitry and the measured characteristics a statistical value indicative of the allele.Type: ApplicationFiled: February 16, 2023Publication date: April 25, 2024Inventors: Barry MERRIMAN, Paul Mola, Mark Gardner
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Publication number: 20240026471Abstract: Biomolecular sensors and methods of manufacturing these sensors are provided. An exemplary sensor has a source electrode, a drain electrode spaced apart from the source electrode by a sensor gap, a gate electrode, wherein the source, drain and gate electrodes cooperate to form an electrode circuit, a bridge bridging across said sensor gap coupling the source and drain electrodes, and a probe coupled to the bridge, wherein the probe comprises nucleic acid and interaction of the nucleic acid probe with a target nucleic acid is detectable by monitoring at least one parameter of the electrode circuit. Methods of detecting a target nucleic acid are also provided. Preferred target nucleic acids that are detected are from pathogens, such as coronavirus.Type: ApplicationFiled: June 15, 2021Publication date: January 25, 2024Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Carl Fuller, Paul Mola, Hadi Abderrahim, Pius S. Padayatti
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Publication number: 20240018190Abstract: In various embodiments, a synthetic peptide finding use as a molecular wire in a molecular electronic circuit comprises an alpha helical segment further comprising repeating alpha-helical motifs. The synthetic peptide may further comprise at least one specific conjugation site between the termini for attachment to a molecule such as a binding probe, and may further comprise termini having metal binding functionality such as repeats of material binding sequences. In various aspects, the synthetic peptide comprises intramolecular hydrogen bonding, salt bridges, and optionally, aromatic rings that provide for electrical conductivity through the peptide.Type: ApplicationFiled: January 10, 2020Publication date: January 18, 2024Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Tim Geiser, Venkatesh Alagarswarmy Govindaraj
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Publication number: 20240011941Abstract: The present disclosure discloses a polymer synthesis and assembly chip that includes a semiconductor integrated circuit device that contains a plurality of pixels, wherein each pixel of the plurality of pixels contains an electrode; and wherein a set of pixels of the plurality of pixels is capable of synthesizing a polymer; and wherein a set of pixels of the plurality of pixels is capable of assembling a synthesized polymer, either independently or in concert with one or more pixels of the plurality of pixels; and control circuitry capable of applying voltages to the electrode. The present disclosure includes related methods of use, such as methods for error correction, for use with the described polymer synthesis and assembly chip.Type: ApplicationFiled: June 9, 2022Publication date: January 11, 2024Inventors: Matthew T. HOLDEN, Barry MERRIMAN, Ryan DE RIDDER, Kyle T. GUSTAFSON, Michael HELLER
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Publication number: 20230321625Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: ApplicationFiled: February 16, 2023Publication date: October 12, 2023Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Patent number: 11724244Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: GrantFiled: April 13, 2022Date of Patent: August 15, 2023Assignee: Avery Digital Data, Inc.Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Publication number: 20230204538Abstract: In various embodiments of the present disclosure, a molecular electronics sensor array chip comprises: (a) an integrated circuit semiconductor chip; and (b) a plurality of molecular electronic sensor devices disposed thereon, each of said sensor devices comprising: (i) a pair of nanoscale source and drain electrodes separated by a nanogap; (ii) a gate electrode; and (iii) a bridge and/or probe molecule spanning the nanogap and connecting the source and drain electrodes, wherein the molecular electronic sensor devices are organized into an electronically addressable, controllable, and readable array of sensor pixels.Type: ApplicationFiled: March 6, 2023Publication date: June 29, 2023Applicant: Roswell ME Inc.Inventors: Barry Merriman, Paul W. Mola, Chulmin Choi
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Patent number: 11597971Abstract: A method of genotyping includes applying a sample solution including a plurality of copies of a sample polynucleotide to an array of sensors. The sample polynucleotide includes a region associated with an allele. The method further includes measuring using a plurality of sensors of the array of sensors a characteristic of the region of the plurality of copies of the sample polynucleotide and determining using a computational circuitry and the measured characteristics a statistical value indicative of the allele.Type: GrantFiled: October 30, 2014Date of Patent: March 7, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Barry Merriman, Paul Mola, Mark Gardner
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Publication number: 20230038666Abstract: Various aspects of the present disclosure provide methods, apparatus and systems for single-molecule biosensors having nanowire or nanoribbon bridges between electrodes for sequencing and information storage and reading. In various embodiments, the present disclosure provides nanofabrication of biomolecular sensing devices beginning with parallel arrangements of transferable nanowires or nanoribbons, and provides in general methods of manufacturing biosensor devices for sequencing DNA or RNA and analyzing biomolecules.Type: ApplicationFiled: December 28, 2020Publication date: February 9, 2023Applicant: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Chulmin Choi, Jihye Baek, Paul W. Mola, Barry Merriman
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Publication number: 20220390407Abstract: A processive enzyme molecular sensor for use in a DNA data storage system is disclosed that can extract digital information suitably encoded into a synthetic DNA molecule. In various aspects, such sensors are provided in a high-density chip-based format that can provide the high throughput, low-cost and fast data extraction capability required for large scale DNA data storage systems. The sensor for reading the digital data stored in DNA molecules processes individual encoded DNA molecules directly, eliminating the need for complicated sample preparation such as making copies of DNA or clonal populations of such molecules.Type: ApplicationFiled: June 13, 2022Publication date: December 8, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Paul W. Mola, Tim Geiser, Gina Costa
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Publication number: 20220371012Abstract: A method of manufacturing a device useable in DNA or genome sequencing comprises disposing pairs of electrodes on a substrate, the electrodes within each pair separated by a nanogap; depositing a resist layer over the electrodes; patterning the resist layer to create an exposed region on each electrode at or near each nanogap; roughening the electrode surface within each exposed region using various methods; and exposing the exposed regions to biomolecules, wherein one biomolecule bridges each nanogap of each electrode pair, with each end of each biomolecule bound to the electrodes at each exposed region.Type: ApplicationFiled: August 2, 2022Publication date: November 24, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Chulmin Choi, Sungho Jin, Paul W. Mola, Barry Merriman
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Publication number: 20220325330Abstract: Described herein is a portable virometer for detecting viral targets. An exemplary virometer has a molecular electronics sensor with a first electrode, a second electrode spaced-apart from the first electrode by a nanogap, a bridge molecule having a first end and a second end, the first end coupled to the first electrode and the second end coupled to the second electrode, a hybridization probe having an oligonucleotide sequence from or related to a viral target is conjugated to the bridge molecule, a sample applicator for acquiring a sample and transferring it to the chip, and data processing software and hardware for providing a report of detection of viral targets. Methods of using the virometer for testing in the home, in schools, in workplaces, in hotels, in restaurants, or in public places are also described.Type: ApplicationFiled: December 20, 2021Publication date: October 13, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Carl Fuller, Paul Mola
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Publication number: 20220299467Abstract: A structure usable in a molecular sensor device comprises a substrate defining a substrate plane and spaced apart pairs of reducible metal oxide or metal nitride sheets attached to the substrate at an angle to the substrate plane. The structure further includes intervening dielectric sheets. Fabrication methods for manufacturing structures for molecular sensors are disclosed comprising oblique angle deposition of reducible metal oxide or metal nitride and dielectric layers, planarization of the resulting stack, and reduction of portions of the reducible metal oxide or metal nitride sheets to the corresponding base metal.Type: ApplicationFiled: August 18, 2020Publication date: September 22, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Sungho Jin, Barry Merriman, Tim Geiser, Paul W. Mola
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Publication number: 20220280906Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: ApplicationFiled: April 13, 2022Publication date: September 8, 2022Applicant: Avery Digital Data, Inc.Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Publication number: 20220282311Abstract: A molecular electronics sensor capable of performing genetic analysis is described. In various embodiments, the sensor comprises spaced-apart electrodes, a bridge molecule coupled to the electrodes, and an oligonucleotide hybridization probe conjugated to the bridge molecule. The hybridization probe may comprise an oligonucleotide sequence complementary to a segment of a pathogen genome to be detected. In various aspects, a plurality of such sensors are disposed as an array of pixels on a CMOS chip. Sensors herein can be configured to detect a segment of SARS-CoV-2 genome in a bio-sample.Type: ApplicationFiled: September 15, 2021Publication date: September 8, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Carl Fuller, Barry Merriman, Paul W. Mola, Hadi Abderrahim, Andrew Hodges
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Publication number: 20220252542Abstract: The disclosed embodiments relate to nanotechnology and to nano-electronics and molecular electronic sensors. In an exemplary embodiment, a nano-sensor having a nanoparticle complex attached at each end to a respective nano-electrode. An exemplary nanoparticle complex includes a biomolecule coupled at each end to a metallic nanoparticle to form a dumbbell-shaped molecular bridge.Type: ApplicationFiled: January 13, 2022Publication date: August 11, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Sonal Jain, Drew Kennedy, Venkatesh Alagarswamy Govindaraj, Calvin Gardner, Chulmin Choi, Namseok Park, Richard Dubielzig, Le Zheng, David Porras, Paul Pan
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Publication number: 20220213531Abstract: A molecular electronics sensor capable of performing genetic analysis is described. In various embodiments, the sensor comprises spaced-apart electrodes, a bridge molecule coupled to the electrodes, and an oligonucleotide hybridization probe conjugated to the bridge molecule. The hybridization probe may comprise an oligonucleotide sequence complementary to a segment of a pathogen genome to be detected. In various aspects, a plurality of such sensors are disposed as an array of pixels on a CMOS chip. Sensors herein can be configured to detect a segment of SARS-CoV-2 genome in a bio-sample.Type: ApplicationFiled: September 15, 2021Publication date: July 7, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Carl Fuller, Barry Merriman, Paul W. Mola, Hadi Abderrahim, Andrew Hodges
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Patent number: 11371955Abstract: A processive enzyme molecular sensor for use in a DNA data storage system is disclosed that can extract digital information suitably encoded into a synthetic DNA molecule. In various aspects, such sensors are provided in a high-density chip-based format that can provide the high throughput, low-cost and fast data extraction capability required for large scale DNA data storage systems. The sensor for reading the digital data stored in DNA molecules processes individual encoded DNA molecules directly, eliminating the need for complicated sample preparation such as making copies of DNA or clonal populations of such molecules.Type: GrantFiled: August 30, 2018Date of Patent: June 28, 2022Assignee: ROSWELL BIOTECHNOLOGIES, INC.Inventors: Barry Merriman, Tim Geiser, Paul Mola, Gina Costa
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Publication number: 20220154241Abstract: In various embodiments a molecular circuit is disclosed. The circuit comprises a negative electrode, a positive electrode spaced apart from the negative electrode, and an enzyme molecule conductively attached to both the positive and negative electrodes to form a circuit having a conduction pathway through the enzyme. In various examples, the enzyme is a polymerase. The circuit may further comprise molecular arms used to wire the enzyme to the electrodes. In various embodiments, the circuit functions as a sensor, wherein electrical signals, such as changes to voltage, current, impedance, conductance, or resistance in the circuit, are measured as substrates interact with the enzyme.Type: ApplicationFiled: January 27, 2022Publication date: May 19, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Venkatesh Alagarswamy Govindaraj, Paul Mola, Tim Geiser
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Publication number: 20220148682Abstract: In various embodiments, amplification-free DNA information methods, apparatus and systems are disclosed. A method of amplification-free information storage and retrieval comprises encoding digital data such as binary into nucleotide sequence motifs using an encoding scheme, and synthesizing replicate DNA molecules using an amplification-free DNA writing process. The amplification-free process of decoding the information stored in the DNA comprises exposing at least one of the replicate DNA molecules to a molecular electronics sensor that generates distinguishable signals in a measured electrical parameter of the sensor, wherein the distinguishable signals correspond to the sequence motifs, providing decoding back to the digital data.Type: ApplicationFiled: July 13, 2021Publication date: May 12, 2022Applicant: Roswell Biotechnologies, Inc.Inventors: Barry Merriman, Tim Geiser, Paul Mola, Gina Costa