Patents by Inventor Barry Morgan

Barry Morgan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Synthesis of Encoded Libraries
    Publication number: 20200149034
    Abstract: Methods of producing compounds and combinatorial compound libraries, the compounds and libraries produced via the methods are provided, and methods of using the libraries to identify compounds having a desired property, such as a desired biological activity and the compounds identified using these methods are provided.
    Type: Application
    Filed: March 16, 2018
    Publication date: May 14, 2020
    Inventors: Jin Li, Barry A. Morgan, Jinqiao Wan, Dengfeng Dou, Guansai Liu, Yong Chang, Qiuxia Chen, Xing Wang, Yanshan Xu, Dongyan Hu, Jian Liu, Xuemin Cheng
  • Somatostatin antagonists
    Patent number: 9133262
    Abstract: The invention features somatostatin antagonists having a D-amino acid at the second residue.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: September 15, 2015
    Assignees: Ipsen Pharma S.A.S., The Administrators of the Tulane Educational Fund
    Inventors: David H. Coy, Barry Morgan, William Murphy
  • Methods for synthesis of encoded libraries
    Patent number: 8598089
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: December 3, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffan Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 8410028
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: April 2, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffan Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20120245040
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 27, 2012
    Applicant: GlaxoSmithKline
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES
    Publication number: 20120071329
    Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 18, 2011
    Publication date: March 22, 2012
    Applicant: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20110251089
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: March 18, 2011
    Publication date: October 13, 2011
    Applicant: GlaxoSmithKline
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • sEH inhibitors and their use
    Patent number: 7994317
    Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: August 9, 2011
    Assignee: GlaxoSmithKline, LLC
    Inventors: Yun Ding, Joseph Paul Marino, Jr., Peng Li, Allyn T. Londregan, Barry A. Morgan
  • Methods for identifying compounds of interest using encoded libraries
    Patent number: 7989395
    Abstract: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: August 2, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 7972992
    Abstract: The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: July 5, 2011
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 7972994
    Abstract: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: July 5, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paulo A. Centrella, Raksha A. Acharya
  • METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
    Publication number: 20110136697
    Abstract: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
    Type: Application
    Filed: February 9, 2011
    Publication date: June 9, 2011
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Barry MORGAN, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Methods for synthesis of encoded libraries
    Patent number: 7935658
    Abstract: The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: May 3, 2011
    Assignee: Praecis Pharmaceuticals, Inc.
    Inventors: Barry Morgan, Stephen Hale, Christopher C. Arico-Muendel, Matthew Clark, Richard Wagner, David I. Israel, Malcolm L. Gefter, Dennis Benjamin, Nils Jakob Vest Hansen, Malcolm J. Kavarana, Steffen Phillip Creaser, George J. Franklin, Paolo A. Centrella, Raksha A. Acharya
  • Prenyl transferase inhibitors
    Patent number: 7691859
    Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: April 6, 2010
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan
  • Novel sEH Inhibitors and Their Use
    Publication number: 20100069391
    Abstract: The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.
    Type: Application
    Filed: November 2, 2007
    Publication date: March 18, 2010
    Inventors: Yun Ding, Joseph Paul Marino, Peng Li, Allyn T. Londregan, Barry A. Morgan
  • Imidazolyl derivatives
    Patent number: 7638546
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: December 29, 2009
    Assignee: IPSEN Pharma S.A.S.
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Thomas D. Gordon, Barry A. Morgan, Christophe Philippe Moinet, Dennis C. H. Bigg
  • PRODUCT COMPRISING A TRANSDUCTION INHIBITOR OF HETEROTRIMERIC G PROTEIN SIGNALS COMBINED WITH ANOTHER ANTI-CANCER AGENT FOR THERAPEUTIC USE IN THE TREATMENT OF CANCER
    Publication number: 20090270341
    Abstract: A composition for treating cancer comprising an anti-tumorally effective amount of a product comprising at least one transduction inhibitor of heterotrimeric G protein signals and at least one other anti-cancer agent selected from the group consisting of prenyltransferase inhibitors, taxol and its analogues, gemcitabine and camptothecin and its analogues, administered simultaneously, separately or spread over a period of time and a pharmaceutical carrier.
    Type: Application
    Filed: July 2, 2009
    Publication date: October 29, 2009
    Applicant: IPSEN PHARMA S.A.S.
    Inventors: Gregoire PREVOST, Marie-Odile Lonchampt, Thomas Gordon, Barry Morgan
  • Somatostatin Antagonists
    Publication number: 20090253638
    Abstract: The invention features somatostatin antagonists having a D-amino acid at the second residue.
    Type: Application
    Filed: April 13, 2009
    Publication date: October 8, 2009
    Inventors: David H. Coy, Barry Morgan, William Murphy
  • Imidazolyl derivatives
    Patent number: 7566734
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: July 28, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Thomas D. Gordon, Barry A. Morgan, Christophe Philippe Moinet, Dennis C. H. Bigg
  • Farnesyl transferase inhibitors
    Patent number: 7553975
    Abstract: A family of compounds capable of inhibiting the activity of farnesyl transferase.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: June 30, 2009
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Thomas D. Gordon, Barry A. Morgan