Patents by Inventor Barry R. Lutz
Barry R. Lutz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230272462Abstract: Kits, methods, polypeptides, systems, and non-transitory, machine-readable storage media for detecting a nucleic acid in a sample are described. In an embodiment, the kit comprises a loop primer nucleic acid molecule configured for loop-mediated isothermal amplification (LAMP), the loop primer nucleic acid molecule comprising: a targeting sequence complementary to a target portion of a target nucleic acid sequence; and an adapter sequence; a displacement nucleic acid probe comprising: a fluorophore adapter sequence; and the adapter sequence; and a fluorophore adapter complement nucleic acid molecule complementary to the fluorophore adapter sequence, wherein the fluorophore adapter sequence or the fluorophore adapter complement nucleic acid molecule is coupled to a fluorophore. In an embodiment, the system comprises a thermal subsystem for heating a sample disposed therein, and an optical subsystem for optically excited the sample and detecting light emitted from the sample.Type: ApplicationFiled: July 9, 2021Publication date: August 31, 2023Applicant: UNIVERSITY OF WASHINGTONInventors: Enos Kline, Michael Roller, Robert G. Atkinson, Nuttada Panpradist, Daniel Leon, Ian Hull, Qin Wang, Barry R. Lutz
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Publication number: 20230134587Abstract: Embodiments disclosed herein relate to apparatuses, systems, and methods for detecting biomarkers in biological samples present in assay tests using a control strip and indicator strip, where the control strip includes reagents that form a reactive gas which reacts with the biomarker on the indicator strip, if present. Methods of using the test apparatuses include taking a sending photographs of a used test apparatus to a medical provider to demonstrate adherence to a pharmaceutical treatment regimen.Type: ApplicationFiled: August 15, 2022Publication date: May 4, 2023Inventors: Sarah J. Iribarren, Barry R. Lutz, Daniel Leon, Marcus Rhodehamel, Jesse Keyes, Hannah Erdy, Mohamed Adil, Rishika Das, Kyle Goodwin
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Patent number: 11247030Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: GrantFiled: December 27, 2018Date of Patent: February 15, 2022Assignee: University of WashingtonInventors: Samuel R. Browd, Barry R. Lutz
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Publication number: 20200395127Abstract: In some embodiments, a system for using various types of information to augment the determination of a post-test probability of the presence of a condition is provided. In some embodiments, the information may include detailed health status or sub-population prevalence information, gathered in real-time, in order to provide a more accurate pre-test probability value. In some embodiments, the information may include augmentation information that helps provide a more accurate likelihood ratio for a given analytical test. In some embodiments, the more accurate likelihood ratios that are calculated using the augmentation information can be used to select a most-useful test for a given situation. In some embodiments, the augmentation information may include a multivariate model that allows a post-test probability to be determined using an analytic test result and various factors related to the subject without explicitly determining a pre-test probability nor a likelihood ratio.Type: ApplicationFiled: November 19, 2018Publication date: December 17, 2020Applicant: University of WashingtonInventors: Barry R. Lutz, Rahil Jain, Blythe Adamson
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Publication number: 20190126018Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: ApplicationFiled: December 27, 2018Publication date: May 2, 2019Inventors: Samuel R. Browd, Barry R. Lutz
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Patent number: 10166375Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: GrantFiled: March 24, 2015Date of Patent: January 1, 2019Assignee: University of WashingtonInventors: Samuel R. Browd, Barry R. Lutz
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Publication number: 20180326418Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a base configured to receive one or more fluids, a porous wick carried by the base portion, and a flow-metering element along the porous wick to modify a rate or volume of fluid flow along the porous wick. The porous wick can comprise a first pathway, a second pathway, and an intersection at which the first pathway and the second pathway converge. Input ends of the first and second pathways can be wettably distinct. Upon wetting of the input ends, fluid is configured to travel by capillary action along each pathway. The device may also include volume-metering features configured to automatically and independently control or modify a volume of fluid flow along one or more pathways of the porous wick.Type: ApplicationFiled: May 14, 2018Publication date: November 15, 2018Applicant: University of WashingtonInventors: Paul Yager, Barry R. Lutz, Elain S. Fu, Peter C. Kauffman
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Publication number: 20180028794Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: ApplicationFiled: October 6, 2017Publication date: February 1, 2018Inventors: Samuel R. Browd, Barry R. Lutz
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Patent number: 9662478Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: GrantFiled: March 21, 2011Date of Patent: May 30, 2017Assignee: University of WashingtonInventors: Samuel R. Browd, Barry R. Lutz
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Patent number: 9528987Abstract: The present technology describes various embodiments of devices for processing, analyzing, detecting, measuring, and separating fluids. The devices can be used to perform these processes on a microfluidic scale, and with control over fluid and reagent transport. In one embodiment, for example, a device for performing chemical processes can include a porous wick comprising a pathway defined by an input end, an output end, and a length between the input end and the output end. The pathway is configured to wick fluid from the input end to the output end by capillary action. The device can further include a reagent placed on the pathway. The reagent can be placed in a pattern configured to control a spatial or temporal distribution of the reagent along the pathway upon wetting of the pathway.Type: GrantFiled: June 25, 2012Date of Patent: December 27, 2016Assignee: University of WashingtonInventors: Paul Yager, Barry R. Lutz, Elain S. Fu, Gina Fridley, Huy Quang Le, Peter C. Kauffman
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Publication number: 20160101270Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: ApplicationFiled: December 17, 2015Publication date: April 14, 2016Inventors: Samuel R. Browd, Barry R. Lutz
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Publication number: 20150196742Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: ApplicationFiled: March 24, 2015Publication date: July 16, 2015Inventors: Samuel R. Browd, Barry R. Lutz
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Publication number: 20140227707Abstract: The present technology describes various embodiments of devices for processing, analyzing, detecting, measuring, and separating fluids. The devices can be used to perform these processes on a microfluidic scale, and with control over fluid and reagent transport. In one embodiment, for example, a device for performing chemical processes can include a porous wick comprising a pathway defined by an input end, an output end, and a length between the input end and the output end. The pathway is configured to wick fluid from the input end to the output end by capillary action. The device can further include a reagent placed on the pathway. The reagent can be placed in a pattern configured to control a spatial or temporal distribution of the reagent along the pathway upon wetting of the pathway.Type: ApplicationFiled: June 25, 2012Publication date: August 14, 2014Applicant: University of Washington Through itsCenter for ComInventors: Paul Yager, Barry R. Lutz, Elain S. Fu, Gina Fridley, Huy Quang Le, Peter C. Kauffman
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Publication number: 20130197422Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: ApplicationFiled: March 21, 2011Publication date: August 1, 2013Applicant: UW CENTER FOR COMMERCIALIZATIONInventors: Samuel R. Browd, Barry R. Lutz
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Publication number: 20120302938Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter having an exterior surface, a proximal portion, and a distal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.Type: ApplicationFiled: June 4, 2012Publication date: November 29, 2012Applicant: University of WashingtonInventors: Samuel R. Browd, Barry R. Lutz
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Publication number: 20120288961Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a base configured to receive one or more fluids, a porous wick carried by the base portion, and a flow-metering element along the porous wick to modify a rate or volume of fluid flow along the porous wick. The porous wick can comprise a first pathway, a second pathway, and an intersection at which the first pathway and the second pathway converge. Input ends of the first and second pathways can be wettably distinct. Upon wetting of the input ends, fluid is configured to travel by capillary action along each pathway. The device may also include volume-metering features configured to automatically and independently control or modify a volume of fluid flow along one or more pathways of the porous wick.Type: ApplicationFiled: December 21, 2010Publication date: November 15, 2012Applicant: University of WashingtonInventors: Paul Yager, Barry R. Lutz, Elain S. Fu, Peter C. Kauffman
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Patent number: 7803599Abstract: A microfluidic fluid flow system (100) is disclosed having a fluid chamber or channel (150) with inlet and outlet ports (104, 106), allowing the fluid channel to be filled with a fluid. One or more flow obstructions or perturbances, such as cylinders (152), are provided in the channel. An oscillatory boundary condition is applied, for example, with a piezoelectric driver (130), that is selected to induce a conservative, low-intensity steady streaming flow in the channel. The low-intensity streaming flow produces distinct eddies that can be utilized, for example, for fluid-dynamically trapping or retaining particles (90) such as cells (92) at well defined locations in the channel. The system may be used to trap and study individual cells or for concentrating or filtering particles in a fluid.Type: GrantFiled: January 18, 2005Date of Patent: September 28, 2010Assignee: University of WashingtonInventors: Barry R. Lutz, Daniel T. Schwartz