Patents by Inventor Bartley P. Griffith
Bartley P. Griffith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230248939Abstract: A modular cannula for drainage and return of fluids from and to a body, such as the body of a patient, is adjustable to enable an operator to achieve desired flow characteristics during such fluid drainage and return procedures. The modular, dual-lumen cannula system has an outer drainage cannula and an inner return cannula that is moveable with respect to the outer drainage cannula. By enabling movement of the inner return cannula with respect to the outer drainage cannula, a distance between return outlet ports at the distal end of the return cannula and drainage ports at the distal end of the drainage cannula may be manually adjusted. Such adjustable distance allows for optimal positioning of both the drainage and return ports that are particularly adapted to an individual patient’s physiology, in turn enabling optimal fluid flow characteristics to be achieved regardless of that patient physiology.Type: ApplicationFiled: February 10, 2023Publication date: August 10, 2023Inventors: Bartley P. Griffith, Zhongjun Wu, Chetan Pasrija, Aakash Yogesh Shah, Zachary Kon
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Publication number: 20220347362Abstract: The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.Type: ApplicationFiled: July 7, 2022Publication date: November 3, 2022Inventors: Zhongjun WU, Bartley P. GRIFFITH, Jiafeng ZHANG, Steven J. ORWIG
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Patent number: 11433168Abstract: The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.Type: GrantFiled: February 14, 2020Date of Patent: September 6, 2022Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, BREETHE, INC.Inventors: Zhongjun Wu, Bartley P. Griffith, Jiafeng Zhang, Steven J. Orwig
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Publication number: 20210346581Abstract: A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.Type: ApplicationFiled: July 20, 2021Publication date: November 11, 2021Inventors: Zhongjun WU, Bartley P. GRIFFITH
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Patent number: 11065375Abstract: A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.Type: GrantFiled: December 17, 2018Date of Patent: July 20, 2021Assignee: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Zhongjun Wu, Bartley P. Griffith
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Publication number: 20210121659Abstract: Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (“SLC”) configurations and double lumen cannula (“DLC”) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patient's body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patient's blood vessel or a portion of the system inserted into the patient's blood vessel) from collapsing as fluid is drained from the patient.Type: ApplicationFiled: January 6, 2021Publication date: April 29, 2021Inventors: Zhongjun WU, Bartley P. GRIFFITH, Jun DING
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Patent number: 10912920Abstract: Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (SLC) configurations and double lumen cannula (DLC) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patients body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patients blood vessel or a portion of the system inserted into the patients blood vessel) from collapsing as fluid is drained from the patient.Type: GrantFiled: July 17, 2014Date of Patent: February 9, 2021Assignees: University of Maryland, Baltimore, University of Maryland, Baltimore CountyInventors: Zhongjun Wu, Bartley P. Griffith, Jun Ding
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Publication number: 20200405944Abstract: The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. The disclosed cannula can be implemented as a single lumen cannula or a double lumen cannula, which can be used with ventricular assist devices for heart support or pump-oxygenators for ECMO and respiratory support. Through a self-sealing mechanism fixed on the ventricular wall or atrial wall, a cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula. In the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location.Type: ApplicationFiled: June 3, 2020Publication date: December 31, 2020Inventors: Zhongjun WU, Bartley P. GRIFFITH, Keshava RAJAGOPAL
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Publication number: 20200206404Abstract: The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.Type: ApplicationFiled: February 14, 2020Publication date: July 2, 2020Inventors: Zhongjun WU, Bartley P. GRIFFITH, Jiafeng ZHANG, Steven J. ORWIG
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Patent number: 10695483Abstract: The present invention discloses a self-sealing cannula that through a self-sealing mechanism fixed on the ventricular wall or atrial wall, the cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula; in the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location.Type: GrantFiled: November 11, 2015Date of Patent: June 30, 2020Assignee: University of Maryland, BaltimoreInventors: Zhongjun Wu, Bartley P. Griffith, Keshava Rajagopal
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Publication number: 20190224456Abstract: Disclosed herein is a guidewire configured for placement of large bore catheters and cannulae inside of a patient's blood vessels without fluoroscopic guidance. The guidewire, in accordance with certain aspects of an embodiment of the invention, comprises sections of varying stiffness throughout optimally fixed length portions of the guidewire that particularly ease placement of such large bore catheters and cannulae in ECMO applications.Type: ApplicationFiled: January 24, 2019Publication date: July 25, 2019Inventors: Zachary Kon, Bartley P. Griffith, Mehrdad Ghoreishi, Chetan Pasrija, Gregory Bittle
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Publication number: 20190209761Abstract: A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.Type: ApplicationFiled: December 17, 2018Publication date: July 11, 2019Inventors: Zhongjun WU, Bartley P. GRIFFITH
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Patent number: 10258729Abstract: A method for pumping and oxygenating blood includes receiving a flow of gas including oxygen into a gas inlet manifold via a gas inlet. The flow of gas is passed through the hollow fibers from the gas inlet manifold to a gas outlet manifold. The flow of gas is output from the gas outlet manifold via a gas outlet. An impeller is rotated to generate a flow of blood that flows over the hollow fibers. Oxygen from the flow of gas is transferred to the flow of blood through the hollow fibers. Carbon dioxide is transferred from the flow of blood to the flow of gas through the hollow fibers.Type: GrantFiled: January 28, 2016Date of Patent: April 16, 2019Assignees: Thoratec LLC, University of Maryland, BaltimoreInventors: Barry N. Gellman, Andrew Koert, Zhongjun Wu, Juntao Zhang, Bartley P. Griffith
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Patent number: 10188780Abstract: A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.Type: GrantFiled: December 23, 2014Date of Patent: January 29, 2019Assignee: University of Maryland, BaltimoreInventors: Zhongjun Wu, Bartley P. Griffith
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Publication number: 20170303958Abstract: The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. The disclosed cannula can be implemented as a single lumen cannula or a double lumen cannula, which can be used with ventricular assist devices for heart support or pump-oxygenators for ECMO and respiratory support. Through a self-sealing mechanism fixed on the ventricular wall or atrial wall, a cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula. In the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location.Type: ApplicationFiled: November 11, 2015Publication date: October 26, 2017Inventors: Zhongjun WU, Bartley P. GRIFFITH, Keshava RAJAGOPAL
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Publication number: 20170021081Abstract: A method for pumping and oxygenating blood includes receiving a flow of gas including oxygen into a gas inlet manifold via a gas inlet. The flow of gas is passed through the hollow fibers from the gas inlet manifold to a gas outlet manifold. The flow of gas is output from the gas outlet manifold via a gas outlet. An impeller is rotated to generate a flow of blood that flows over the hollow fibers. Oxygen from the flow of gas is transferred to the flow of blood through the hollow fibers. Carbon dioxide is transferred from the flow of blood to the flow of gas through the hollow fibers.Type: ApplicationFiled: January 28, 2016Publication date: January 26, 2017Inventors: Barry N. Gellman, Andrew Koert, Zhongjun Wu, Juntao Zhang, Bartley P. Griffith
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Publication number: 20160296685Abstract: A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.Type: ApplicationFiled: December 23, 2014Publication date: October 13, 2016Inventors: Zhongjun WU, Bartley P. GRIFFITH
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Publication number: 20160158489Abstract: Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (SLC) configurations and double lumen cannula (DLC) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patients body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patients blood vessel or a portion of the system inserted into the patients blood vessel) from collapsing as fluid is drained from the patient.Type: ApplicationFiled: July 17, 2014Publication date: June 9, 2016Inventors: Zhongjun WU, Bartley P. GRIFFITH, Jun DING
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Patent number: 9278168Abstract: An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).Type: GrantFiled: June 26, 2013Date of Patent: March 8, 2016Assignee: THORATEC LLCInventors: Barry N. Gellman, Andrew Koert, Zhongjun Wu, Juntao Zhang, Bartley P. Griffith
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Publication number: 20150030664Abstract: The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.Type: ApplicationFiled: October 3, 2014Publication date: January 29, 2015Applicants: UNIVERSITY OF MARYLAND, BALTIMORE, UNIVERSITY OF MARYLAND AT COLLEGE PARKInventors: Brendan J. CASEY, Peter KOFINAS, Adam BEHRENS, Trevor A. SNYDER, Bartley P. GRIFFITH