Abstract: A laser system for changing the index of refraction of cornea tissue in a living eye. The laser system comprises a laser that provides laser pulses with a wavelength from 400 nm to 900 nm and a pulse energy from 0.01 nJ to 10 nJ, and a control device for setting the operating parameters of the laser below an optical breakdown threshold of the tissue to avoid photo-disruption and tissue destruction of the tissue, and to direct the laser pulses at the cornea tissue resulting in a change in the index of refraction of the tissue within regions irradiated by the laser pulses.

Abstract: A stable ophthalmic pharmaceutical composition for relief, treatment, control, alleviation, or prevention of a pathological ocular condition of the eye comprises: (a) a first polymer, a viscosity of which changes with a change in a concentration of an electrolyte, such as a salt, when added to said first polymer; (b) a second polymer that is different from the first polymer and can modify the viscosity of the first polymer; and (c) an oil. In some embodiments, the composition further comprises a non-ionic surfactant. The composition can form a stable oil-in-water emulsion on storage, but separate into an oil phase and a water phase when applied in the eye. The emulsion can comprises an ophthalmic active pharmaceutical ingredient dissolved in the oil or water phase. The emulsion can provide enhanced stability to said active pharmaceutical ingredient.

Abstract: The invention is directed to a method of cleaning and disinfecting a contact lens. The method includes instructing a consumer to disinfect their contact lens comprising the following steps: remove a contact from an eye and position the lens in a lens assembly that includes a cap member; add a disinfection solution to the lens case such that the lens is submerged in the solution upon closure of the lens case with the cap member. The disinfection solution will comprise 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound. The presence of the P-metal modulating compound in the disinfection solution decreases the neutralization rate of the hydrogen peroxide. The disinfection system exhibits a pseudo first-order, half-life of hydrogen peroxide from 12 minutes to 30 minutes over an initial sixty minutes of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal.

Abstract: A brimonidine pamoate polymorph exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.

Abstract: A brimonidine pamoate polymorph exhibits characteristics disclosed herein. The polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.

Abstract: An intraocular lens injector, comprising an injector body having a lumen wall defining a lumen, a plunger configured and arranged to move an IOL through the lumen, and a vibration source configured and arrange to vibrate at least one of the injector body and the plunger.

Abstract: A device for measuring a lens, comprising apparatus for maintaining the lens at a location, at least a first point source, a second point source and a third point source, at least a first beam splitter, and a second beam splitter, and a wavefront sensor configured and arranged to receive a wavefront of light from the first source, a wavefront of light from the second source, and a wavefront of light from the third source after the light from each source has passed through the lens. The point sources and beam splitters are arranged such that the first source has a first object distance relative to the location, the second source has a second object distance relative to the location, the third source has a third object distance relative to the location, the first object distance, the second object distance, and the third object distance being different than one another.

Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain monoethylenically unsaturated polymerizable group containing polycarbosiloxane monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices.

Abstract: A laser system for modifying the index of refraction of an optical hydrogel material. The laser system comprises a computer program to determine the position and shape of refractive structures to be written into the optical hydrogel material to correct a patient's vision, and a focused laser that generates laser light having a wavelength of from 400 nm to 900 nm, and which operates with an average power of 10 mW to 1000 mW to produce a pulse energy from 0.05 nJ to 1000 nJ with a peak intensity at focus of greater than 1013 W/cm2. The refractive structures exhibit a change in the index of refraction of 0.01 to 0.06 in the optical hydrogel material.

Abstract: An ophthalmic composition comprises an ophthalmic drug that has a low solubility in water and a surfactant, wherein the ophthalmic drug is present at a concentration from about 3 to about 7000 times the solubility of the drug in water. A volume of about 1-15 microliter is administered topically to an eye of a subject to treat or control a condition for which the drug is effective.

Abstract: Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated-containing monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing macromonomer having hydrophilic units and boronic acid units are disclosed.

Abstract: An intraocular lens comprising: (a) monomeric units derived from at least one cationically polymerizable branched alkene monomer; (b) monomeric units derived from at least one cationically polymerizable monomer having a pendant benzocyclobutene group; and (c) a UV-absorbing benzotriazole component having the formula I.