Patents by Inventor Beau Webber

Beau Webber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intracellular genomic transplant and methods of therapy
    Patent number: 11925664
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 12, 2024
    Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Branden Moriarity, Beau Webber, David Largaespada, Modassir Choudhry, Steven A. Rosenberg
  • Intracellular genomic transplant and methods of therapy
    Patent number: 11903966
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: February 20, 2024
    Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, INTIMA BIOSCIENCE, INC., The U.S.A., as represented by the Secretary, Department f Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • DELIVERY OF MOLECULES TO CELLS USING TROGOCYTOSIS AND ENGINEERED CELLS
    Publication number: 20240042029
    Abstract: Provided herein are methods and compositions for targeted delivery of cargo molecules, including, for example, gene editing reagents, RNA binding proteins, therapeutic agents, or other cargo via trogocytosis. In particular, provided herein are genetically modified donor cells as well as methods of using such genetically modified donor cells to deliver cargo of interest fused to a transmembrane receptor to a specific acceptor target cell.
    Type: Application
    Filed: December 8, 2021
    Publication date: February 8, 2024
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Branden Moriarity, Beau Webber, Kenta Yamamoto, Joseph Skeate
  • ENGINEERED IMMUNE CELLS FOR REAGENT DELIVERY
    Publication number: 20240026292
    Abstract: The present invention provides genetically modified lymphocyte with reduced cytotoxicity. Also provided are methods of using these genetically modified lymphocytes to deliver cargo molecules to a target cell.
    Type: Application
    Filed: September 9, 2021
    Publication date: January 25, 2024
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Branden MORIARITY, Beau WEBBER, Emily POMEROY
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
    Patent number: 11760983
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: September 19, 2023
    Assignee: B-Mogen Biotechnologies, Inc.
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • ENHANCED hAT FAMILY MEMBER SPIN TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20230272355
    Abstract: This disclosure provides various SPIN transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: June 4, 2021
    Publication date: August 31, 2023
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Bryan Jones
  • Intracellular genomic transplant and methods of therapy
    Patent number: 11642375
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: May 9, 2023
    Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Intracellular genomic transplant and methods of therapy
    Patent number: 11642374
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: May 9, 2023
    Assignees: INTIMA BIOSCIENCE, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Modified cells and methods of therapy
    Patent number: 11583556
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: February 21, 2023
    Assignees: Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, R. Scott McIvor, David Largaespada, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
    Publication number: 20220362297
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: February 17, 2022
    Publication date: November 17, 2022
    Inventors: Branden MORIARITY, Beau WEBBER, Modasir CHOUDHRY, Steven A. ROSENBERG, Douglas C. PALMER, Nicholas P. RESTIFO
  • GENETICALLY-EDITED IMMUNE CELLS AND METHODS OF THERAPY
    Publication number: 20220282285
    Abstract: The disclosure provides genetically-edited immune cells, methods of generating genetically-edited immune cells, and methods of therapy. In some embodiments, the methods described herein comprise contacting a plurality of mammalian cells with a polynucleic acid construct that comprises an insert sequence flanked by homology arms, wherein said homology arms comprise a sequence homologous to at most 400 consecutive nucleotides of a sequence adjacent to a target site in the genome of said plurality of mammalian cells.
    Type: Application
    Filed: March 22, 2022
    Publication date: September 8, 2022
    Inventors: Beau WEBBER, Branden MORIARITY
  • ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
    Publication number: 20220280569
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: March 10, 2022
    Publication date: September 8, 2022
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL
  • MODIFIED CELLS AND METHODS OF THERAPY
    Publication number: 20220125843
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Application
    Filed: September 17, 2021
    Publication date: April 28, 2022
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, R. Scott McIvor, David Largaespada, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • Enhanced hAT Family Transposon-Mediated Gene Transfer and Associated Compositions, Systems, and Methods
    Publication number: 20220112472
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Application
    Filed: October 22, 2021
    Publication date: April 14, 2022
    Applicant: B-MoGen Biotechnologies, Inc.
    Inventors: David LARGAESPADA, Branden MORIARITY, Beau WEBBER, Neil OTTO, Sandeep KUMAR, Leah HOGDAL
  • TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY
    Publication number: 20220105133
    Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
    Type: Application
    Filed: September 22, 2021
    Publication date: April 7, 2022
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • GENETICALLY MODIFIED GAMMA DELTA T CELLS AND METHODS OF MAKING AND USING
    Publication number: 20220088074
    Abstract: Provided herein are genome-edited ?? T cells that exhibit an increased capacity to kill cancer cells, methods of producing genome-edited ?? T cells, and methods of treating or preventing a condition by administering genome-edited ?? T cells to a subject in need thereof.
    Type: Application
    Filed: February 21, 2020
    Publication date: March 24, 2022
    Inventors: Beau Webber, Branden Moriarity, Emily Joy Pomeroy, Patricia Nicole Claudio Vazquez
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
    Patent number: 11278570
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: March 22, 2022
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
  • Intracellular genomic transplant and methods of therapy
    Patent number: 11266692
    Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: March 8, 2022
    Assignees: Regents of the University of Minnesota, Intima Bioscience, Inc., The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Branden Moriarity, Beau Webber, Modassir Choudhry, Steven A. Rosenberg, Douglas C. Palmer, Nicholas P. Restifo
  • PROGRAMMABLE NUCLEASES AND BASE EDITORS FOR MODIFYING NUCLEIC ACID DUPLEXES
    Publication number: 20220002717
    Abstract: Provided herein are methods and compositions for highly precise base editing and single strand nicking. In particular, provided herein are methods for producing a genetically modified cell where the methods employ a universal, highly precise base editor or staggered Cas9 editor for precise base editing with minimal off-target or bystander effects.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 6, 2022
    Inventors: Branden Moriarity, Mitchell Kluesner, Beau Webber
  • Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
    Patent number: 11162084
    Abstract: This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: November 2, 2021
    Assignee: B-MOGEN BIOTECHNOLOGIES, INC.
    Inventors: David Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal