Abstract: A method for monitoring ionized Mg2+ concentrations and ionized Ca2+:Mg2+ ratios in a patient, useful in diagnosing and prognosing disease states including headache, cardiopulmonary bypass surgery, hypertension, abnormal pregnancy, head trauma, and fetal abnormalities is provided as well as a composition and a method of treating a patient with ionized Mg2+ or ionized Ca2+ and Mg2+. A method of treating headache is provided.

Abstract: A method of treating headache is provided using a water soluble magnesium salt. Specifically, a method of treating a headache is provided for an individual having a serum ionized magnesium concentration of 0.44 mmoles/L to 0.53 mmoles/L and having at least one headache symptom by administering an amount of a water soluble magnesium salt sufficaent to inhibit at least one headache symptom in the individual within 24 hours and to raise the serum ionized magnesium concentration in the individual to within a normal ionized magnesium concentration range of 0.54 mmoles/L to 0.67 mmoles/L. Headache symptoms which may be inhibited include: pain, aura, photophobia, nausea, unilateral pain and phonophobia.

Abstract: The present invention provides a method for preparing and storing biological samples prior to measuring ionized Mg.sup.2+ concentrations in order to obtain accurate and reproducible readings. A novel method for accurately reading ionized magnesium ion concentrations in biological samples is provided. A method for monitoring ionized Mg.sup.2+ concentrations and ionized Ca.sup.2+ :Mg.sup.2+ ratios in a patient, useful in diagnosing and prognosing disease states including cardiopulmonary bypass surgery, hypertension, abnormal pregnancy, head trauma, cardiac diseases, lung diseases, pre-eclampsia, eclampsia, migraine, renal diseases, and fetal abnormalities is provided as well as a method of treating a patient with ionized Mg.sup.2+.

Abstract: The present invention is an substance-induced-hemorrhagic stroke animal model. The substance-induced-hemorrhagic stroke animal model is useful in screening therapeutics for the prevention and/or treatment of stroke. The present invention also encompasses magnesium salt for the prevention and treatment of stroke.

Abstract: The present invention provides a method for preparing and storing biological samples prior to measuring ionized Mg.sup.2+ concentrations in order to obtain accurate and reproducible readings. A novel method for accurately reading ionized magnesium ion concentrations in biological samples is provided. A method for monitoring ionized Mg.sup.2+ concentrations and ionized Ca.sup.2+ :Mg.sup.2+ ratios in a patient, useful in diagnosing and prognosing disease states including cardiopulmonary bypass surgery, hypertension, abnormal pregnancy, head trauma, and fetal abnormalities is provided as well as a composition and a method of treating a patient with ionized Mg.sup.2+ or ionized Ca.sup.2+ and Mg.sup.2+.

Abstract: The present invention provides a method for preparing and storing biological samples prior to measuring ionized Mg.sup.2+ concentrations in order to obtain accurate and reproducible readings. A novel method for accurately reading ionized magnesium ion concentrations in biological samples is provided. A method for monitoring ionized Mg.sup.2+ concentrations and ionized Ca.sup.2+ :Mg.sup.2+ ratios in a patient, useful in diagnosing and prognosing disease states including cardiopulmonary bypass surgery, hypertension, abnormal pregnancy, head trauma, and fetal abnormalities is provided as well as a composition and a method of treating a patient with ionized Mg.sup.2+ or ionized Ca.sup.2+ and Mg.sup.2+.