Patents by Inventor Bellur S. Prabhakar
Bellur S. Prabhakar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230340413Abstract: This invention relates to chimeric polypeptides comprising OX40L and Jagged-1 polypeptides and fragments thereof and their uses for treatment of autoimmune diseases.Type: ApplicationFiled: October 18, 2022Publication date: October 26, 2023Inventors: Bellur S. Prabhakar, Palash Bhattacharya, Prabhakaran Kumar
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Publication number: 20180320135Abstract: This invention relates to chimeric polypeptides comprising OX40L and Jagged-1 polypeptides and fragments thereof and their uses for treatment of autoimmune diseases.Type: ApplicationFiled: November 3, 2016Publication date: November 8, 2018Inventors: Bellur S. Prabhakar, Palash Bhattacharya, Prabhakaran Kumar
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Patent number: 10072081Abstract: The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a T-cell cell surface and a second specific binding activity for Glucose Transporter 2 (GLUT2) or an extracellular ectodomain thereof expressed on a pancreatic ?-cell surface, wherein binding of the first polypeptide or polypeptide domain to CTLA-4 induces a CTLA-4 specific agonist response in the T-cell, and binding of the second polypeptide or polypeptide domain to GLUT2 or an ectodomain thereof does not inhibit GLUT2 glucose transporter function, wherein said agonist response in the T-cell induces a response that reduces immunoreactivity against pancreatic ?-cells.Type: GrantFiled: November 17, 2015Date of Patent: September 11, 2018Assignee: The Board of Trustees of the University of IllinoisInventors: Bellur S. Prabhakar, Chenthamarakshan Vasu, Palash Bhattacharya
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Publication number: 20160137736Abstract: The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a T-cell cell surface and a second specific binding activity for Glucose Transporter 2 (GLUT2) or an extracellular ectodomain thereof expressed on a pancreatic ?-cell surface, wherein binding of the first polypeptide or polypeptide domain to CTLA-4 induces a CTLA-4 specific agonist response in the T-cell, and binding of the second polypeptide or polypeptide domain to GLUT2 or an ectodomain thereof does not inhibit GLUT2 glucose transporter function, wherein said agonist response in the T-cell induces a response that reduces immunoreactivity against pancreatic ?-cells.Type: ApplicationFiled: November 17, 2015Publication date: May 19, 2016Applicant: The Board of Trustees of The University of IllinoisInventors: Bellur S. PRABHAKAR, Chenthamarakshan VASU, Palash BHATTACHARYA
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Patent number: 9221911Abstract: The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a T-cell cell surface and a second specific binding activity for Glucose Transporter 2 (GLUT2) or an extracellular ectodomain thereof expressed on a pancreatic ?-cell surface, wherein binding of the first polypeptide or polypeptide domain to CTLA-4 induces a CTLA-4 specific agonist response in the T-cell, and binding of the second polypeptide or polypeptide domain to GLUT2 or an ectodomain thereof does not inhibit GLUT2 glucose transporter function, wherein said agonist response in the T-cell induces a response that reduces immunoreactivity against pancreatic ?-cells.Type: GrantFiled: March 15, 2013Date of Patent: December 29, 2015Inventors: Bellur S. Prabhakar, Chenthamarakshan Vasu, Palash Bhattacharya
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Methods For Inhibiting Viruses By Targeting Cathepsin-L Cleavage Sites In The Viruses' Glycoproteins
Publication number: 20150150878Abstract: The disclosure provides methods and compositions useful for inhibiting virus requiring membrane fusion for viral entry, specifically for inhibiting severe acute respiratory syndrome coronavirus (SARS-CoV), Ebola virus (EBOV), Hendra (HeV) and Nipah (NIV) viruses by targeting Cathepsin-L (CatL) cleavages sites in the viruses' glycoproteins.Type: ApplicationFiled: April 4, 2013Publication date: June 4, 2015Inventors: Bellur S. Prabhakar, Hatem A. Elshabrawy -
Patent number: 8822649Abstract: The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a T-cell cell surface and a second specific binding activity for Glucose Transporter 2 (GLUT2) or an extracellular ectodomain thereof expressed on a pancreatic ?-cell surface, wherein binding of the first polypeptide or polypeptide domain to CTLA-4 induces a CTLA-4 specific agonist response in the T-cell, and binding of the second polypeptide or polypeptide domain to GLUT2 or an ectodomain thereof does not inhibit GLUT2 glucose transporter function, wherein said agonist response in the T-cell induces a response that reduces immunoreactivity against pancreatic ?-cells.Type: GrantFiled: July 17, 2013Date of Patent: September 2, 2014Assignee: The Board of Trustees of the University of IllinoisInventors: Bellur S. Prabhakar, Chenthamarakshan Vasu, Palash Bhattacharya
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Patent number: 8722637Abstract: Methods and compositions relating to IG20 expression, splice variants of IG20, effects of endogenous DENN-SV function with respect to processes regulating cell proliferation, cell survival and cell death are disclosed.Type: GrantFiled: September 22, 2004Date of Patent: May 13, 2014Assignee: The Board of Trustees of the University of IllinoisInventor: Bellur S. Prabhakar
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Publication number: 20130323250Abstract: The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a T-cell cell surface and a second specific binding activity for Glucose Transporter 2 (GLUT2) or an extracellular ectodomain thereof expressed on a pancreatic ?-cell surface, wherein binding of the first polypeptide or polypeptide domain to CTLA-4 induces a CTLA-4 specific agonist response in the T-cell, and binding of the second polypeptide or polypeptide domain to GLUT2 or an ectodomain thereof does not inhibit GLUT2 glucose transporter function, wherein said agonist response in the T-cell induces a response that reduces immunoreactivity against pancreatic ?-cells.Type: ApplicationFiled: July 17, 2013Publication date: December 5, 2013Inventors: Bellur S. PRABHAKAR, Chenthamarakshan VASU, Palash BHATTACHARYA
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Publication number: 20130236464Abstract: The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) expressed on a T-cell cell surface and a second specific binding activity for Glucose Transporter 2 (GLUT2) or an extracellular ectodomain thereof expressed on a pancreatic ?-cell surface, wherein binding of the first polypeptide or polypeptide domain to CTLA-4 induces a CTLA-4 specific agonist response in the T-cell, and binding of the second polypeptide or polypeptide domain to GLUT2 or an ectodomain thereof does not inhibit GLUT2 glucose transporter function, wherein said agonist response in the T-cell induces a response that reduces immunoreactivity against pancreatic ?-cells.Type: ApplicationFiled: March 15, 2013Publication date: September 12, 2013Inventors: Bellur S. PRABHAKAR, Chenthamarakshan VASU, Palash BHATTACHARYA
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Publication number: 20110117627Abstract: Pro-apoptotic signaling caused by down-modulation of KIAA0358 or expression of IG20-SV4 effectively induces spontaneous apoptosis and sensitization to TNF?-induced apoptosis in neuroblastoma cells. Methods and composition to enhance cell death in neuroblastoma are provided. Methods and compositions to reduce cell death in neurodegenerative disorders are provided.Type: ApplicationFiled: July 10, 2009Publication date: May 19, 2011Applicant: The Board of Trustees of the University of IllinoisInventors: Bellur S. Prabhakar, Matthew N. Meriggioli, Liang Cheng LI
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Patent number: 7910723Abstract: Methods and compositions inhibit the growth of cancer cells by selectively down-regulating the expression of an IG20 splice variant including MADD. Specific knock-down of MADD splice variant resulted in the apoptosis of cancer cells. Interfering RNAs including small hairpin RNAs (shRNA) to down-regulate MADD expression in vivo are disclosed. Inhibition of MADD phosphorylation by Akt results in activation of cancer cell death. Down-regulation of MADD expression results in switching to apoptotic mode due to lack of MAPK activation upon TNF-?-based induction.Type: GrantFiled: July 16, 2008Date of Patent: March 22, 2011Assignee: The Board of Trustees of the University of IllinoisInventors: Bellur S. Prabhakar, Nirupama Mulherkar
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Patent number: 7728110Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV S protein, and that function to neutralize SARS-CoV. The invention also relates to antibodies that are bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-SARS-CoV S protein antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-SARS-CoV S protein antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.Type: GrantFiled: May 21, 2007Date of Patent: June 1, 2010Assignee: Amgen, Inc.Inventors: John S. Babcook, Bellur S. Prabhakar, Melissa Coughlin
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Publication number: 20090232854Abstract: GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells is useful for the control of autoimmune diseases such as myasthenia gravis MG.Type: ApplicationFiled: March 10, 2009Publication date: September 17, 2009Applicant: The Board of Trustees of the University of IllinoisInventors: Bellur S. Prabhakar, Mark J. Holterman, Chenthamarakshan Vasu, Matthew N. Meriggioli
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Patent number: 7527972Abstract: GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells is useful for the control of autoimmune diseases such as myasthenia gravis MG.Type: GrantFiled: November 16, 2006Date of Patent: May 5, 2009Assignee: The Board of Trustees of the University of IllinoisInventors: Bellur S. Prabhakar, Mark J. Holterman, Chenthamarakshan Vasu, Matthew N. Meriggioli
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Publication number: 20090075929Abstract: Methods and compositions inhibit the growth of cancer cells by selectively down-regulating the expression of an IG20 splice variant including MADD. Specific knock-down of MADD splice variant resulted in the apoptosis of cancer cells. Interfering RNAs including small hairpin RNAs (shRNA) to down-regulate MADD expression in vivo are disclosed. Inhibition of MADD phosphorylation by Akt results in activation of cancer cell death. Down-regulation of MADD expression results in switching to apoptotic mode due to lack of MAPK activation upon TNF-?-based induction.Type: ApplicationFiled: July 16, 2008Publication date: March 19, 2009Applicant: The Board of Trustees of the University of IllinoisInventors: Bellur S. Prabhakar, Nirupama Mulherkar
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Publication number: 20080248043Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV S protein, and that function to neutralize SARS-CoV. The invention also relates to antibodies that are bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-SARS-CoV S protein antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-SARS-CoV S protein antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.Type: ApplicationFiled: May 21, 2007Publication date: October 9, 2008Applicant: Amgen Inc.Inventors: John S. Babcook, Bellur S. Prabhakar, Melissa Coughlin
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Publication number: 20080233645Abstract: Methods and compositions relating to IG20 expression, splice variants of IG20, effects of endogenous DENN-SV function with respect to processes regulating cell proliferation, cell survival and cell death are disclosed.Type: ApplicationFiled: September 22, 2004Publication date: September 25, 2008Inventor: Bellur S. Prabhakar