Abstract: The present disclosure relates to compositions and methods for treating cancers. In particular, the present disclosure provides materials and methods for identifying mis-splicing-associated surface antigens (MASAs) generated by altered spliceosome proteins, as well as materials and methods for targeting cancerous tumors expressing MASAs.

Abstract: A Cloud-based method, system and computer-readable medium of creating a virtual tour is described. The method comprises allowing a user to upload images for stitching of a 360 panorama image; creating a virtual tour based on the 360 panorama image; and allowing the user to edit the virtual tour by embedding an object for the user to interact with, when the virtual tour is viewed with a Virtual Reality (VR) headset.

Abstract: A hatch assembly for use in a vehicle is provided. The hatch assembly includes a hatch structure including an upper portion and a lower portion, an armrest support rail coupled to the hatch structure and defining a shade slot between the hatch structure and the armrest support rail, and a shade sized for insertion through the shade slot. The shade is configured to selectively translate between the upper portion and the lower portion of the hatch structure through the shade slot.

Abstract: A hatch assembly for use in a vehicle is provided. The hatch assembly includes a hatch structure including an upper portion and a lower portion, an armrest support rail coupled to the hatch structure and defining a shade slot between the hatch structure and the armrest support rail, and a shade sized for insertion through the shade slot. The shade is configured to selectively translate between the upper portion and the lower portion of the hatch structure through the shade slot.

Abstract: Butterfly valves assemblies are provided that include a flowbody, a butterfly plate, an actuator and an upper chimney and a lower chimney disposed within the flowbody. The flowbody has an inner surface defining a channel. The butterfly plate is disposed in the channel, is rotationally mounted to the flowbody, and has an outer periphery. The actuator has an actuator output shaft that is coupled to the valve shaft via a serrated spline coupling. The upper chimney and the lower chimney are configured to include bearing assemblies that constrain radial loads and thrust loads exerted upon the valve shaft and minimize misalignment of the serrated spline coupling.

Abstract: An air turbine starter for starting an engine includes a housing, and a flow path communicating a flow of gas therethrough; a turbine member; a clutch; and a decoupler device at least partially housed within the output member of the clutch. The decoupler device includes a first shaft portion coupled to and rotating with the output member and a second shaft portion coupled to and rotating with the engine. The first and second shaft portions are axially aligned and configured to engage each another for rotation in a first direction and to separate from each other in a second direction to decouple the output member of the clutch from the engine. The starter further includes a bearing between the inner surface of the output member and the second shaft portion for reducing friction between the second shaft portion and the inner surface of the output member when the first and second shaft portions are decoupled.

Abstract: Butterfly valves assemblies are provided that include a flowbody, a butterfly plate, an actuator and an upper chimney and a lower chimney disposed within the flowbody. The flowbody has an inner surface defining a channel. The butterfly plate is disposed in the channel, is rotationally mounted to the flowbody, and has an outer periphery. The actuator has an actuator output shaft that is coupled to the valve shaft via a serrated spline coupling. The upper chimney and the lower chimney are configured to include bearing assemblies that constrain radial loads and thrust loads exerted upon the valve shaft and minimize misalignment of the serrated spline coupling.

Abstract: A composition and method of using are provided, which composition includes: at least one compound selected from the group including a compound having formula (I), a salt thereof, a prodrug thereof, a compound having formula (II), a salt thereof, a prodrug thereof, and a combination thereof, the compounds being described herein, and a combination thereof, and at least one pharmaceutically acceptable carrier; wherein the composition is suitable for administration to a mammal. Methods of using the compound are also provided.

Abstract: An air turbine starter for starting an engine includes a housing, and a flow path communicating a flow of gas therethrough; a turbine member; a clutch; and a decoupler device at least partially housed within the output member of the clutch. The decoupler device includes a first shaft portion coupled to and rotating with the output member and a second shaft portion coupled to and rotating with the engine. The first and second shaft portions are axially aligned and configured to engage each another for rotation in a first direction and to separate from each other in a second direction to decouple the output member of the clutch from the engine. The starter further includes a bearing between the inner surface of the output member and the second shaft portion for reducing friction between the second shaft portion and the inner surface of the output member when the first and second shaft portions are decoupled.

Abstract: An isolated nucleic acid molecule comprising a modified Murine Leukemia Virus Long Terminal Repeat sequence that is capable of tropically regulating expression of operably linked coding sequences in a vessel endothelial cell is disclosed. A method of producing a non-Murine Leukemia Virus protein in a vessel endothelial cell is disclosed. The method comprises the step of introducing into the cell a nucleic acid molecule that comprises a modified Murine Leukemia Virus Long Terminal Repeat sequences operably linked to a nucleotide sequence which encodes a non-Murine Leukemia Virus protein, the modified Murine Leukemia Virus Long Terminal Repeat sequences being capable of tropically regulating expression in vessel endothelial cells.