Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.

Abstract: A drill guide assembly for drilling a tunnel having a fixed, non-zero radius of curvature, where the drill guide assembly includes a housing and a sleeve, or cutting tube, configured to reciprocate within the distal portion where the sleeve, or cutting tube, is configured to receive a bone cutting instrument.

Abstract: A drill guide assembly for drilling a tunnel having a fixed, non-zero radius of curvature, where the drill guide assembly includes a housing and a sleeve, or cutting tube, configured to reciprocate within the distal portion where the sleeve, or cutting tube, is configured to receive a bone cutting instrument.

Abstract: A surgical instrument stabilizer system that includes an articulating boom that is releasably connectable to a surgical table side rail. The articulating boom includes an actuator, a multi-directional flexible arm having a first end region attached to the actuator, and a cable extending through the flexible arm. The cable has one end region connected to the actuator and another end region connected to a preload tensioning mechanism. The actuator is operable to tighten and loosen the cable, and the preload tensioning mechanism maintains an amount of tension in the cable when the actuator loosens the cable. The system further includes a surgical instrument-supporting member that is attached to a second end region of the flexible arm and is configured to releasably retain a surgical instrument.

Abstract: Systems and methods for air cooling a microfluidic device using confinement channels to isolate cooling air from exposed liquids are disclosed. The systems and methods may also thermally condition the cooling airflow for improved robustness of the microfluidic device. In one embodiment, the air cooling system includes a split-level cooling manifold including an inlet duct that directs cooling air to a microfluidic device and an outlet duct that directs air heated by the microfluidic device away from the microfluidic device. The temperature of cooling air may be measured. The cooling air may be preheated to a temperature that is higher than an expected ambient temperature. The temperature of the cooling air after being heated by a microfluidic device may be measured.

Abstract: A fluid sampling device (100) that operates by a combination of capillary action to collect a small fluid sample, and by pressure differential when inserted into an analyzer (200) to expose the fluid sample for testing by the analyzer (200). The device is especially suited for use as a disposable blood sampling unit designed to interface with a blood analyzer, albeit the concept of the invention may be employed for sampling and testing virtually any fluids.

Abstract: In one aspect, the present invention provides methods, devices, and systems for ensuring that multiple components of a mixture are fully mixed in a continuous flow microfluidic system while ensuring that mixing between segments flowing through the chip is minimized. In some embodiments, the present invention includes mixing fluids in a droplet maintained at the tip of a pipette before the mixture is introduced to the microfluidic device. In another aspect, the present invention provides methods, devices, and systems for creating segments that move through a microfluidic chip with minimal mixing between segments. The microfluidic chip may have an interface chip and a reaction chip. In some embodiments, the present invention includes creating segments that flow through an interface chip and a reaction chip, wherein the interface chip and a reaction chip have separate flow control mechanisms and produce minimal mixing between segments.

Abstract: In one aspect, the present invention provides methods, devices, and systems for ensuring that multiple components of a mixture are fully mixed in a continuous flow microfluidic system while ensuring that mixing between segments flowing through the chip is minimized. In some embodiments, the present invention includes mixing fluids in a droplet maintained at the tip of a pipette before the mixture is introduced to the microfluidic device. In another aspect, the present invention provides a pipette tip having a ratio of an outside diameter to an inside diameter that provides sufficient surface area for a droplet comprising up to the entire volume of the liquid to suspend from the pipette tip intact. In yet another aspect, the present invention provides methods, devices, and systems for delivering a reaction mixture to a microfluidic chip comprising a docking receptacle, an access tube and a reservoir.

Abstract: The present invention relates generally to systems and methods for the rapid serial processing of multiple nucleic acid assays. More particularly, the present invention provides for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g.

Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.

Abstract: A drill guide assembly for drilling a tunnel having a fixed, non-zero radius of curvature, where the drill guide assembly includes a housing and a sleeve, or cutting tube, configured to reciprocate within the distal portion where the sleeve, or cutting tube, is configured to receive a bone cutting instrument.

Abstract: A surgical instrument stabilizer system for securely holding virtually any instrument during any procedure, delivering vacuum when applicable, and yet allowing easy single-handed or voice activated repositioning by a user. The system utilizes opposing horizontal side-rails mounted to opposing sides of a surgical table, and opposing arms each slidably mounted on a side rail for global lengthwise positioning along the side rails. The arms carry a transverse beam at the foot of the operating table, and a flexible arm is movably mounted on the beam for global lengthwise positioning along the beam. Alternately, the flexible arm may be affixed directly to one of the existing horizontal side rails. The flexible arm leads to an instrument-supporting hand piece pivotally mounted for angular orientation of an instrument supported thereby. The flexible arm can be freely articulated to any position and locked in place.

Abstract: An ultrasonic field-portable system for accurately measuring hematocrit (HCT) and hemoglobin concentration (HGB) in small food samples. The system includes an analyzer (10) that allows extremely accurate measurements of blood hematocrit from only one or two drops of +>>d collected in a disposable sampling device (12) that is then inserted into the analyzer (10). The system is compact enough to package into a point of care device, making it a point of care device with accuracy comparable to larger CBC lab equipment.

Abstract: Disclosed herein is a hair-grasping EEG electrode and an insertion tool for placement of the electrode on the scalp. The electrode has a novel two-piece clamping design formed of cooperating halves that capture and tension the hair, pulling the electrode snuggly against the scalp before locking together to anchor the electrode in place. The insertion tool allows easy manipulation and fast and consistent installation without need for lengthy user training and practice. Moreover, the insertion tool assumes some of the functionality so that the electrode can be simplified, allowing a smaller footprint and part count, as well as allowing the non-conductive portions of the electrode to be disposable. Dispensing of electrolytic gel is a convenient option to improve the interface, and this may be readily dispensed from the tool, or from reservoirs integral to the electrode. The combination greatly reduces EEG study setup time and technician labor costs.

Abstract: A fluid sampling device (100) that operates by a combination of capillary action to collect a small fluid sample, and by pressure differential when inserted into an analyzer (200) to expose the fluid sample for testing by the analyzer (200). The device is especially suited for use as a disposable blood sampling unit designed to interface with a blood analyzer, albeit the concept of the invention may be employed for sampling and testing virtually any fluids.

Abstract: An ultrasonic field-portable system for accurately measuring hematocrit (HCT) and hemoglobin concentration (HGB) in small food samples. The system includes an analyzer (10) that allows extremely accurate measurements of blood hematocrit from only one or two drops of +>>d collected in a disposable sampling device (12) that is then inserted into the analyzer (10). The system is compact enough to package into a point of care device, making it a point of care device with accuracy comparable to larger CBC lab equipment.

Abstract: A wind meter comprising a plurality of micro-electro-mechanical (MEM) differential pressure sensors positioned in a lobed housing, with an even number of circumferential ports arranged in an equally-spaced, circular pattern at the distal ends of the lobes of the housing, with tubes leading inward from the ports to the MEM sensors. The MEM sensors and other control system electronics are contained in the housing and are fully enclosed therein. The lobed housing structure does not impede or influence the movement of the wind as it passes and yet serves to prevent the ingress of moisture into the housing, thereby preventing fouling of the sensors. The tubular structures include an internal coating of hydrophobic material and are oriented at a slight angle from the horizontal in order to accomplish this protection. The openings at the ends of the tubular structures are positioned outside the fluid boundary layer.