Patents by Inventor Ben Thuronyi

Ben Thuronyi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
    Patent number: 11732274
    Abstract: The instant specification provides for evolved base editors which overcome deficiencies of those in art (including increased efficiency and/or decreased requirement for specific sequence-context at an editing site) and which are obtained a result of a phage-assisted continuous evolution (PACE) system. In particular, the instant specification provides for evolved cytidine base editors (e.g., based on APOBEC1, CDA, or AID cytidine deaminase domains) which overcome deficiencies of those in art (including increased efficiency and/or decreased requirement for specific sequence-context at an editing site) and which are obtained a result of a phage-assisted continuous evolution (PACE) system.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: August 22, 2023
    Assignees: President and Fellows of Harvard College, The Broad Institute, Inc.
    Inventors: David R. Liu, Ben Thuronyi, Christopher Gerard Wilson
  • METHODS AND COMPOSITIONS FOR EVOLVING BASE EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
    Publication number: 20200172931
    Abstract: The instant specification provides for evolved base editors which overcome deficiencies of those in art (including increased efficiency and/or decreased requirement for specific sequence-context at an editing site) and which are obtained a result of a phage-assisted continuous evolution (PACE) system. In particular, the instant specification provides for evolved cytidine base editors (e.g., based on APOBEC1, CDA, or AID cytidine deaminase domains) which overcome deficiencies of those in art (including increased efficiency and/or decreased requirement for specific sequence-context at an editing site) and which are obtained a result of a phage-assisted continuous evolution (PACE) system.
    Type: Application
    Filed: July 27, 2018
    Publication date: June 4, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: David R. Liu, Ben Thuronyi, Christopher Gerard Wilson