Abstract: The invention relates to indole derivatives of formula (I) or (II) for use as inflammation modulators, especially having an inhibitory effect on protein kinases. Formula (I), wherein n=0 or 1, R1=R2=3-indole, R3═COOH— or a ketone, X═O or NH; with the proviso that if n=0, R4═OH and R5=3-indole; and if n=1, R4 together with R5 represents an indole ring system condensed to the structure in the 2,3 position and X═NH. Formula (II), wherein R1=R2=3-indole, X═O, CH2 or a carbonyl group; X═O, a carbonyl group NH or >C═N(R′)2 with R′═CH3 or C2H5. The novel indole derivatives isolated from Melassezia are especially useful as substances for producing a medicament for the treatment of inflammatory or proliferative diseases, especially of the skin, but also of other organ systems.