Patents by Inventor Benjamin A. Teply
Benjamin A. Teply has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9688812Abstract: A method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. The nanoparticle may contain a drug. The moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other methods use such libraries, use or administer such polymeric conjugates, or promote the use of such polymeric conjugates. Kits involving such polymeric conjugates are also described.Type: GrantFiled: February 13, 2015Date of Patent: June 27, 2017Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Frank X. Gu, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply
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Patent number: 9080014Abstract: A method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. The nanoparticle may contain a drug. The moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other methods use such libraries, use or administer such polymeric conjugates, or promote the use of such polymeric conjugates. Kits involving such polymeric conjugates are also described.Type: GrantFiled: November 9, 2012Date of Patent: July 14, 2015Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Frank X. Gu, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply
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Publication number: 20150157737Abstract: A method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. The nanoparticle may contain a drug. The moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other methods use such libraries, use or administer such polymeric conjugates, or promote the use of such polymeric conjugates. Kits involving such polymeric conjugates are also described.Type: ApplicationFiled: February 13, 2015Publication date: June 11, 2015Inventors: Frank X. Gu, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply
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Publication number: 20150023875Abstract: The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.Type: ApplicationFiled: April 28, 2014Publication date: January 22, 2015Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Omid C. Farokhzad, Jianjun Cheng, Robert S. Langer, Benjamin A. Teply, Stephen E. Zale
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Publication number: 20140314864Abstract: The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.Type: ApplicationFiled: July 2, 2014Publication date: October 23, 2014Inventors: Jianjun Cheng, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply, Stephen E. Zale
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Patent number: 8802153Abstract: The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.Type: GrantFiled: July 25, 2013Date of Patent: August 12, 2014Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Jianjun Cheng, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply, Stephen E. Zale
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Patent number: 8709483Abstract: The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.Type: GrantFiled: September 26, 2008Date of Patent: April 29, 2014Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Omid C. Farokhzad, Jianjun Cheng, Benjamin A. Teply, Robert S. Langer, Stephen E. Zale
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Publication number: 20140017327Abstract: The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.Type: ApplicationFiled: July 25, 2013Publication date: January 16, 2014Inventors: Jianjun Cheng, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply, Stephen E. Zale
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Patent number: 8367113Abstract: The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety.Type: GrantFiled: May 15, 2007Date of Patent: February 5, 2013Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Frank X. Gu, Benjamin A. Teply, Robert S. Langer, Omid C. Farokhzad
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Patent number: 8323698Abstract: The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety.Type: GrantFiled: September 1, 2010Date of Patent: December 4, 2012Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Frank X. Gu, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply
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Publication number: 20110052697Abstract: The present invention provides systems, methods, and compositions for targeted delivery of a therapeutic agent organs, tissues, cells, extracellular matrix components, and intracellular compartments. The present invention provides a complex comprising a therapeutic or diagnostic agent and a nucleic acid targeting moiety, wherein the agent non-covalently associates with base pairs of the nucleic acid targeting moiety. The invention provides targeted particles comprising a particle and an inventive complex. The present invention provides methods of designing, manufacturing, and using inventive complexes and targeted particles.Type: ApplicationFiled: May 17, 2007Publication date: March 3, 2011Applicants: GWANGJU INSTITUTE OF SCIENCE & TECHNOLOGY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Omid C. Farokhzad, Sangyong Jon, Vaishali Bagalkot, Liangfang Zhang, Benjamin Teply, Etgar Levy-Nissenbaum, Robert S. Langer
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Publication number: 20100323199Abstract: The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety.Type: ApplicationFiled: September 1, 2010Publication date: December 23, 2010Inventors: Frank X. Gu, Benjamin A. Teply, Robert S. Langer, Omid C. Farokhzad
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Publication number: 20100266491Abstract: The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.Type: ApplicationFiled: September 26, 2008Publication date: October 21, 2010Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Omid C. FAROKHZAD, Jianjun CHENG, Benjamin A. TEPLY, Robert S. LANGER, Stephen E. ZALE
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Publication number: 20080081074Abstract: The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety.Type: ApplicationFiled: May 15, 2007Publication date: April 3, 2008Applicants: Massachusetts Institute of Technology, The Brigham & Women's Hospital, Inc.Inventors: Frank Gu, Benjamin Teply, Robert Langer, Omid Farokhzad