Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: A system for detecting a location of a subsurface channel may include a portable frame and a plurality of magnetic coils supported by the frame. The magnetic coils may be spaced apart from one another and ends of each of the magnetic coil are unobstructed by other of the magnetic coils.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined below and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.

Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.

Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.

Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.

Abstract: The invention provides 4-{[1-(aminocarbonyl)-4-piperidinyl]amino}-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, which is the compound of formula (I): or a salt thereof.

Abstract: The invention provides N-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-3-methyl-5-isoxazolecarboxamide or a salt thereof, such as the compound or a pharmaceutically acceptable salt thereof. The invention also provides the use of the compound or salt as an inhibitor of phosphodiesterase type IV (PDE4.

Abstract: Novel PDF inhibitors and novel methods for their use are provided.

Abstract: This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.

Abstract: This invention relates to a method for selecting PDE IV inhibitors which have a salutory therapeutic index, and to compounds having these properties.