Abstract: The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.

Abstract: Disclosed is a method and an oral composition for treating CNS disorders. An embodiment of the invention comprises orally administering an allopregnanolone containing composition to a subject having a CNS disorder. Exemplary CNS disorders include sleep disorders, mood disorders, dysthymic disorders, bipolar disorders, anxiety disorders, stress disorders, compulsive disorders, schizophrenia spectrum disorders, convulsive disorders, memory disorders, cognition disorders, movement disorders, personality disorders, autism spectrum disorders, substance abuse disorders, dementia, pain, traumatic brain injury (TBI), vascular disease, withdrawal syndrome, and tinnitus. The composition and methods disclosed herein exhibit effective oral absorption/bioavailability.

Abstract: Disclosed embodiments include an integrated circuit (IC) comprising a silicon wafer, first and second conductive lines on the silicon wafer. There are first, second and third insulation blocks with portions on the first and second conductive lines and the silicon wafer, a metal pillar on the surface of the first conductive line opposite the silicon wafer, and a conductive adhesive block on the surface of the second conductive line opposite the silicon wafer. The IC also has a lead frame having first and second leads, and a capacitor having first and second capacitor terminals in which the first capacitor terminal is connected to the second lead using conductive adhesive, the second capacitor terminal is connected to the second conductive line through the conductive adhesive block, and the first lead is coupled to the first conductive line.

Abstract: In various embodiments a computer-implemented method for providing sustainability insights to a user designing an object. The method includes determining a value of a sustainability metric associated with a design of an object; determining a target value for the sustainability metric; determining an amount of progress made towards achieving the target value for the sustainability metric based on the value of the sustainability metric and the target value for the sustainability metric; and displaying, via a graphical user interface (GUI), a visual indication of the amount of progress made towards achieving the target value for the sustainability metric.

Abstract: In various embodiments a computer-implemented method for providing sustainability insights to a user designing an object. The method includes determining a first value of a sustainability metric associated with a design of an object, displaying, via a graphical user interface (GUI), a visual indication of the first value of the sustainability metric, and detecting a change to the design of the object. The method further includes, in response to detecting the change to the design of the object, determining a second value of the sustainability metric and displaying, via the GUI, a visual indication of the second value of the sustainability metric.

Abstract: Bevel saws and methods of adjusting a fence of a bevel saw are disclosed herein. The bevel saws include a workpiece support that defines a workpiece support surface. The bevel saws also include a user-actuated assembly and an assembly attachment structure that operatively attaches the user-actuated assembly to the workpiece support. The assembly attachment structure includes a blade bevel angle adjustment mechanism configured to adjust a blade bevel angle of the bevel saw blade. The bevel saws also include a fence that defines a fence surface that extends away from the workpiece support surface. The fence includes a first fence region and a second fence region. The first fence region and the second fence region define a blade-receiving gap therebetween, and the fence further includes a gap adjustment mechanism configured to automatically adjust the blade-receiving gap based, at least in part, on the blade bevel angle.

Abstract: Methods are disclosed herein for treating glaucoma in a subject. In some embodiments, the methods increase retinal ganglion cell survival. The disclosed methods use exosomes and/or miRNA.

Abstract: There is disclosed a modular anaerobic digestion point-of-waste to renewable energy system. The system is directed to a modular and scalable anaerobic digestion system for point-of-waste use. The System includes a pretreatment process for removing inhibitory nutrients from a feedstock, an in-treatment process for providing clean renewable energy and a post-treatment process for further providing clean renewable energy for subsequent use. The System includes a leaching bed; a liquids tank; a mixing tank; an anaerobic digester reactor; a precipitation tank; a stripping tank; a hydrogen sulfide scrubber; a water remover; a gas bladder; a dewaterer; and a flare system.

Abstract: Aircraft, vibration isolation assemblies, and methods of assembling vibration isolation assemblies are provided. An aircraft includes a vibration isolation assembly. The vibration isolation assembly includes a mounting track, a plate, a clamp block, a vibration isolator, and a support fitting. The mounting track defines a cavity and includes flanges that define an opening to the cavity. The plate is configured to be positioned on the flanges outside of the cavity. The clamp block is configured to be fastened to the plate under the flanges of the mounting track within the cavity. The vibration isolator is configured to be laterally constrained by the clamp block within the cavity. The support fitting is configured to be secured to the vibration isolator outside of the cavity.

Abstract: A method for determining a desired intake manifold pressure of an internal combustion engine by means of an iterative method, wherein a cylinder charge is determined for an intake manifold pressure iterated during the iterative method, and the desired intake manifold pressure is determined as a function of the cylinder air charge that has been determined. In addition, a control device for carrying out the method is provided.

Abstract: Methods are disclosed herein for treating glaucoma in a subject. In some embodiments, the methods increase retinal ganglion cell survival. The disclosed methods use exosomes and/or miRNA.

Abstract: Methods are disclosed herein for treating glaucoma in a subject. In some embodiments, the methods increase retinal ganglion cell survival. The disclosed method use exosomes and/or miRNA.

Abstract: The invention features methods and apparatus for concentrating a nucleic acid. Methods of the invention include providing an initial suspension of a nucleic acid and an initial liquid, contacting the initial suspension with a housing having a filter that does not pass the nucleic acid, pressurizing the housing to produce a filtrate and a nucleic acid retentate from the initial solution, and detecting the volume of the nucleic acid retentate. Apparatus of the invention include a chamber configured to hold a filter housing containing a nucleic acid suspension, a pressure source to filter the suspension, and a detector to depressurize the housing upon detecting the volume reaching a predetermined threshold. The methods and apparatus described herein are useful in filtering, concentrating, and reconstituting nucleic acids, such as mRNA, in processes such as complete buffer replacement.

Abstract: The invention features methods and apparatus for producing lipid nanoparticles. Methods of the invention include injecting a lipid solution into an aqueous solution at an automated rate (e.g., a rate controlled by a servo pump). The invention provides methods and apparatus for making lipid nanoparticles possessing a wide range of lipid components and hydrophilic encapsulants, including nucleic acids (e.g., mRNA). Also provided are nanoparticles and compositions thereof made by methods and apparatus of the invention.

Abstract: The invention features methods and apparatus for purifying a sample including an RNA (e.g., an RNA having a poly(A) sequence, such as an mRNA). Methods of the invention involve adding a liquid to a sample container including the sample and a solid affinity material (e.g., oligo(dT) or hydroxyapatite), agitating the contents of the sample, removing the liquid, and eluting the RNA of interest from the sample container. The apparatus of the invention include a sample container and one or more components such as a reservoir, collection container, pressure generating source, valve assembly, and agitation mechanism. Certain apparatus include a rotatable magnet or magnetizable component. The methods and apparatus described herein are useful in providing RNA (e.g., RNA having a poly(A) sequence, such as mRNA) in high yield and with high purity using less solvent than conventional purification techniques.

Abstract: Wall panels for a corrugated paper board container have bulge control lines formed therein to control the bending of the wall panels as the container is loaded with contents, such as liquid containing contents. The bulge control lines are configured to control the bending of the wall panels to mitigate the possibility of undesirable spouting that makes the containers more difficult to store.

Abstract: Methods are disclosed herein for treating glaucoma in a subject. In some embodiments, the methods increase retinal ganglion cell survival. The disclosed method use exosomes and/or miRNA.

Abstract: A method for determining a desired intake manifold pressure of an internal combustion engine by means of an iterative method, wherein a cylinder charge is determined for an intake manifold pressure iterated during the iterative method, and the desired intake manifold pressure is determined as a function of the cylinder air charge that has been determined. In addition, a control device for carrying out the method is provided.

Abstract: A method for processing a plurality of sheet material includes receiving a plurality of sheets of material, transporting, via a transport mechanism, the plurality of sheets, one sheet at a time, past a first image capture device, obtaining, via a first image capture device, a first image of a first set of one or more of the plurality of sheets while being transported past the first image capture device, and determining, via at least one processor, a first caliper measurement of the first set of one or more of the plurality of sheets based on the first image of each of the first set.

Abstract: A method for processing a plurality of sheet material includes receiving a plurality of sheets of material, transporting, via a transport mechanism, the plurality of sheets, one sheet at a time, past a first image capture device, obtaining, via a first image capture device, a first image of a first set of one or more of the plurality of sheets while being transported past the first image capture device, and determining, via at least one processor, a first caliper measurement of the first set of one or more of the plurality of sheets based on the first image of each of the first set.