Patents by Inventor Benjamin Geiger
Benjamin Geiger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932871Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising culturing T cells in the presence of a T cell stimulator, an exogenous CCL21 and an exogenous ICAM1, thereby culturing the T cells. Also provided are cell cultures, isolated T cells and uses of same.Type: GrantFiled: March 2, 2018Date of Patent: March 19, 2024Assignees: YEDA RESEARCH AND DEVELOPMENT CO. LTD., THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTERInventors: Benjamin Geiger, Nir Friedman, Shimrit Lieber, Zelig Eshhar, Tova Waks, Anat Globerson Levin
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Publication number: 20230364062Abstract: A method is disclosed for treating or preventing a myeloid malignancy in a subject harboring a mutation in SRSF2 comprising: (a) analyzing in a sample of the subject for the presence of an SRSF2 mutation; and (b) administering to the subject a therapeutically effective amount of a Rho Kinase inhibitor, or an inhibitor of a downstream effector thereof, upon identification of SRSF2 mutation.Type: ApplicationFiled: April 13, 2023Publication date: November 16, 2023Applicant: Yeda Research and Development Co. Ltd.Inventors: Liran SHLUSH, Tom FLEISCHER, Benjamin GEIGER, Minhua SU
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Patent number: 11125590Abstract: A method of detecting a vibration comprises determining a vibration flag has been set during a running mode of the magnetic field sensor, remaining in the running mode until a predetermined number of vibration flags have been set, and entering a recalibration mode when the predetermined number of vibration flags have been set. A counter can be implemented for each of the plurality of vibration flags to determine if the predetermined number of vibration flags have been set.Type: GrantFiled: May 7, 2019Date of Patent: September 21, 2021Assignee: Allegro MicroSystems, LLCInventors: Benjamin Geiger, David Toebes, Naota Nakayama
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Patent number: 11029176Abstract: A method of detecting a vibration comprises determining a vibration flag has been set during a running mode, entering a vibration mode, providing direction information for a target object during the vibration mode of the magnetic field sensor, holding onto positive peak values and negative peak values of the magnetic field signal during the vibration mode of the magnetic field sensor, and returning to the running mode after receiving at least two clock cycles of the magnetic field signal with no further vibration flags set.Type: GrantFiled: May 7, 2019Date of Patent: June 8, 2021Assignee: Allegro MicroSystems, LLCInventors: Benjamin Geiger, Cédric Gillet
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Publication number: 20200368322Abstract: A method of treating a disease associated with intestinal barrier dysfunction in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which downregulates the amount of glucose in intestinal cells, with the proviso that the disease is not Diabetes or obesity. Other agents for treating diseases associated with intestinal barrier dysfunction are also disclosed.Type: ApplicationFiled: August 6, 2020Publication date: November 26, 2020Applicant: Yeda Research and Development Co. Ltd.Inventors: Benjamin GEIGER, Eran ELINAV, Inna GROSHEVA
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Publication number: 20200355522Abstract: A method of detecting a vibration comprises determining a vibration flag has been set during a running mode, entering a vibration mode, providing direction information for a target object during the vibration mode of the magnetic field sensor, holding onto positive peak values and negative peak values of the magnetic field signal during the vibration mode of the magnetic field sensor, and returning to the running mode after receiving at least two clock cycles of the magnetic field signal with no further vibration flags set.Type: ApplicationFiled: May 7, 2019Publication date: November 12, 2020Applicant: Allegro MicroSystems, LLCInventors: Benjamin Geiger, Cédric Gillet
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Publication number: 20200355521Abstract: A method of detecting a vibration comprises determining a vibration flag has been set during a running mode of the magnetic field sensor, remaining in the running mode until a predetermined number of vibration flags have been set, and entering a recalibration mode when the predetermined number of vibration flags have been set. A counter can be implemented for each of the plurality of vibration flags to determine if the predetermined number of vibration flags have been set.Type: ApplicationFiled: May 7, 2019Publication date: November 12, 2020Applicant: Allegro MicroSystems, LLCInventors: Benjamin Geiger, David Toebes, Naota Nakayama
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Publication number: 20200071669Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising culturing T cells in the presence of a T cell stimulator, an exogenous CCL21 and an exogenous ICAM1, thereby culturing the T cells. Also provided are cell cultures, isolated T cells and uses of same.Type: ApplicationFiled: March 2, 2018Publication date: March 5, 2020Applicants: Yeda Research and Development Co. Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Benjamin GEIGER, Nir FRIEDMAN, Shimrit LIEBER, Zelig ESHHAR, Tova WAKS, An at GLOBERSON LEVIN
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Patent number: 9618400Abstract: In one aspect, a temperature detection circuit includes a first circuit configured to provide a first signal and a comparator circuit configured to provide a warning signal in response to the first signal if a temperature reaches a temperature value. The first signal enables determination of a parameter of a magnetic sensor.Type: GrantFiled: February 12, 2015Date of Patent: April 11, 2017Assignee: ALLEGRO MICROSYSTEMS, LLCInventors: Benjamin Geiger, Devon Fernandez
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Publication number: 20160238462Abstract: In one aspect, a temperature detection circuit includes a first circuit configured to provide a first signal and a comparator circuit configured to provide a warning signal in response to the first signal if a temperature reaches a temperature value. The first signal enables determination of a parameter of a magnetic sensor.Type: ApplicationFiled: February 12, 2015Publication date: August 18, 2016Applicant: ALLEGRO MICROSYSTEMS, LLCInventors: Benjamin Geiger, Devon Fernandez
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Publication number: 20160166582Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.Type: ApplicationFiled: February 23, 2016Publication date: June 16, 2016Applicant: Yeda Research and Development Co. Ltd.Inventors: Irina LAVELIN, Varda ROTTER, Moshe OREN, Ami NAVON, Zvi KAM, Benjamin GEIGER
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Patent number: 9289433Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.Type: GrantFiled: April 29, 2013Date of Patent: March 22, 2016Assignee: Yeda Research and Development Co. Ltd.Inventors: Irina Lavelin, Varda Rotter, Moshe Oren, Ami Navon, Zvi Kam, Benjamin Geiger
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Publication number: 20120083477Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.Type: ApplicationFiled: May 26, 2010Publication date: April 5, 2012Applicant: Yeda Research And Development Co. Ltd.Inventors: Irina Lavelin, Varda Rotter, Moshe Oren, Ami Navon, Zvi Kam, Benjamin Geiger
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Publication number: 20100022626Abstract: The present invention relates to a method of measuring cell migration, the method comprising (a) contacting a cell with a plurality of polystyrene non-fluorescent beads so as to generate a migratory track; and (b) analyzing at least one morphometric parameter of said migratory track, the morphomotric parameter being indicative of cell migration. The present invention also relates to methods of treating a medical condition associated with cell migration, the method comprising administering to a subject in need thereof a therapeutically effective amount of an agent capable of modulating the activity or expression of genes identified using the above assay, thereby treating the medical condition associated with cell migration.Type: ApplicationFiled: August 29, 2006Publication date: January 28, 2010Inventors: Benjamin Geiger, Zvi Kam, Suha Naffar-Abu-Amara
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Patent number: 7455989Abstract: A polynucleotide encoding a chimeric polypeptide is provided. The chimeric polypeptide includes (a) a first polypeptide region being capable of specifically binding at least one detectable molecule; and (b) a second polypeptide region being capable of specifically binding a biological component or macromolecule or targeting a cellular compartment. Methods utilizing the polynucleotide or the chimeric polypeptide for highlighting a cell compartment, a biological component or macromolecule are also provided.Type: GrantFiled: August 17, 2003Date of Patent: November 25, 2008Assignee: Yeda Research and Development Co. Ltd.Inventor: Benjamin Geiger
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Patent number: 7196062Abstract: A method for reducing intraocular pressure and increasing outflow facility from an eye of a subject having glaucoma includes the step of providing in the trabecular meshwork of the eye an amount of caldesmon effective to reduce intraocular pressure and increase outflow facility.Type: GrantFiled: February 18, 2005Date of Patent: March 27, 2007Assignees: Wisconsin Alumni Research Foundation, Yeda Research and Development Co. Ltd.Inventors: Paul L. Kaufman, Benjamin Geiger, Alexander Bershadsky, Teresa Borras
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Publication number: 20060240404Abstract: A method of isolating polynucleotides encoding polypeptides affecting an organization of a subcellular organelle or structure of interest is provided. The method comprises: (a) expressing within a plurality of cells an expression library including a plurality of expression constructs each encoding a polypeptide of interest; (b) highlighting the subcellular organelle or structure of interest of the plurality of cells; and (c) isolating a cell or cells of the plurality of cells in which a cellular distribution and/or level of the subcellular organelle or structure of interest is altered to thereby isolate polypeptides capable of affecting the organization of the subcellular organelle or structure of interest.Type: ApplicationFiled: April 3, 2006Publication date: October 26, 2006Applicant: Yeda Research And Development Co. Ltd.Inventors: Benjamin Geiger, Zvi Kam, Eli Zamir, Alexander Bershadsky, Michael Shtutman, Avri Ben-Ze'ev
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Patent number: 7109459Abstract: An auto-focusing method and device are presented for determining an in-focus position of a sample supported on a substrate plate made of a material transparent with respect to incident electromagnetic radiation. The method utilizes an optical system capable of directing incident electromagnetic radiation towards the sample and collecting reflections of the incident electromagnetic radiation that are to be detected. A focal plane of an objective lens arrangement is located at a predetermined distance from a surface of the substrate, which is opposite to the sample-supporting surface of the substrate. A continuous displacement of the focal plane relative to the substrate along the optical axis of the objective lens arrangement is provided, while concurrently directing the incident radiation towards the sample through the objective lens arrangement to thereby focus the incident radiation to a location at the focal plane of the objective lens arrangement.Type: GrantFiled: March 13, 2003Date of Patent: September 19, 2006Assignee: Yeda Research and Development Company Ltd.Inventors: Zvi Kam, Benjamin Geiger
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Publication number: 20060166186Abstract: A polynucleotide encoding a chimeric polypeptide is provided. The chimeric polypeptide includes (a) a first polypeptide region being capable of specifically binding at least one detectable molecule; and (b) a second polypeptide region being capable of specifically binding a biological component or macromolecule or targeting a cellular compartment. Methods utilizing the polynucleotide or the chimeric polypeptide for highlighting a cell compartment, a biological component or macromolecule are also provided.Type: ApplicationFiled: August 17, 2003Publication date: July 27, 2006Inventor: Benjamin Geiger
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Publication number: 20050261184Abstract: A method for reducing intraocular pressure and increasing outflow facility from an eye of a subject having glaucoma includes the step of providing in the trabecular meshwork of the eye an amount of caldesmon effective to reduce intraocular pressure and increase outflow facility.Type: ApplicationFiled: February 18, 2005Publication date: November 24, 2005Inventors: Paul Kaufman, Benjamin Geiger, Alexander Bershadsky, Teresa Borras