Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using a patient response-based linear cutoff model. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. Real inflammation scores and tumor infiltration scores are determined based on a polar coordinate transformation of the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the real inflammation scores and tumor infiltration scores, a feature space is generated, and linear boundaries or linear cutoffs between a plurality of classifications in the feature space are identified based on the real inflammation scores, the tumor infiltration scores, and patient response data.

Abstract: The present invention relates to the use of cannabinoids in the treatment of a neurodegenerative disease or disorder. In particular the cannabinoids cannabidiolic acid (CBDA) and cannabidivarin (CBDV) were able to produce neuroprotective effects in a mouse model of neurodegenerative disease. In particular these effects were associated with the symptoms associated with amyotrophic lateral sclerosis (ALS). Furthermore, the combination of the cannabinoid tetrahydrocannabinol (THC) with the drug olexisome provided a synergistic disease modifying effect in a mouse model of neurodegenerative disease. In particular these effects were associated with the symptoms associated with ALS.

Abstract: Embodiments of a bundled optical fiber cable are provided. Included therein is a central cable unit spanning a first length from a first end to a second end. The central cable unit has a first plurality of optical fibers disposed within a cable jacket. The bundled optical fiber cable also includes at least one optical fiber drop cable wound around the cable jacket of the central cable unit. Each optical fiber drop cable spans a second length from a first end to a second end. Further, each optical fiber drop cable includes one or more optical fibers disposed within a buffer tube. The first end of each optical fiber drop cable is substantially coterminal with the first end of the central cable unit, and the first length spanned by the central cable unit is longer than the second length spanned by each of the optical fiber drop cables.

Abstract: Embodiments of a bundled optical fiber cable are provided. Included therein is a central cable unit spanning a first length from a first end to a second end. The central cable unit has a first plurality of optical fibers disposed within a cable jacket. The bundled optical fiber cable also includes at least one optical fiber drop cable wound around the cable jacket of the central cable unit. Each optical fiber drop cable spans a second length from a first end to a second end. Further, each optical fiber drop cable includes one or more optical fibers disposed within a buffer tube. The first end of each optical fiber drop cable is substantially coterminal with the first end of the central cable unit, and the first length spanned by the central cable unit is longer than the second length spanned by each of the optical fiber drop cables.

Abstract: A ribbon handler assembly holds an optical fiber ribbon during thermal stripping, cleaving and mass fusion splicing. The handler assembly includes a body defining a ribbon channel in an upper surface, an array section of fiber grooves extending longitudinally a predefined length from one end of the ribbon channel, wherein a nominal spacing of each individual groove of the array section of fiber grooves is greater than a nominal fiber spacing of fibers in an optical fiber ribbon configured to be placed into the ribbon channel.

Abstract: Embodiments of a bundled optical fiber cable are provided. Included therein is a central cable unit spanning a first length from a first end to a second end. The central cable unit has a first plurality of optical fibers disposed within a cable jacket. The bundled optical fiber cable also includes at least one optical fiber drop cable wound around the cable jacket of the central cable unit. Each optical fiber drop cable spans a second length from a first end to a second end. Further, each optical fiber drop cable includes one or more optical fibers disposed within a buffer tube. The first end of each optical fiber drop cable is substantially coterminal with the first end of the central cable unit, and the first length spanned by the central cable unit is longer than the second length spanned by each of the optical fiber drop cables.

Abstract: Embodiments of a bundled optical fiber cable are provided. Included therein is a central cable unit spanning a first length from a first end to a second end. The central cable unit has a first plurality of optical fibers disposed within a cable jacket. The bundled optical fiber cable also includes at least one optical fiber drop cable wound around the cable jacket of the central cable unit. Each optical fiber drop cable spans a second length from a first end to a second end. Further, each optical fiber drop cable includes one or more optical fibers disposed within a buffer tube. The first end of each optical fiber drop cable is substantially coterminal with the first end of the central cable unit, and the first length spanned by the central cable unit is longer than the second length spanned by each of the optical fiber drop cables.

Abstract: Method and tool for promptly aligning the mating port of a gas block with the gas port of a rifle barrel. The prompt alignment of the mating port and gas port is accomplished by using an alignment tool have an alignment port and an alignment slot. The alignment tool is inserted into the gas block such that the alignment port is centered over the mating port and that a portion of the alignment tool protrudes from the gas block. The top surface of the alignment tool is marked circumferentially and the forward end of the gas block is marked perpendicular to the alignment slot. The alignment tool is then removed from the gas block and affixed to the rifle barrel such that the alignment port is centered over the gas port. The barrel is marked through the alignment slot in line with the circumferential marking on the top surface of the alignment tool.

Abstract: Method and tool for promptly aligning the mating port of a gas block with the gas port of a rifle barrel. The prompt alignment of the mating port and gas port is accomplished by using an alignment tool have an alignment port and an alignment slot. The alignment tool is inserted into the gas block such that the alignment port is centered over the mating port and that a portion of the alignment tool protrudes from the gas block. The top surface of the alignment tool is marked circumferentially and the forward end of the gas block is marked perpendicular to the alignment slot. The alignment tool is then removed from the gas block and affixed to the rifle barrel such that the alignment port is centered over the gas port. The barrel is marked through the alignment slot in line with the circumferential marking on the top surface of the alignment tool.

Abstract: An optical fiber distribution system is provided. The system includes a distribution cable having a plurality of cable optical fibers. The system includes a plurality of optical fiber tethers each including a tether optical fiber optically coupled to a cable optical fiber. The tethers provide access to and distribute the optical network at positions along the length of the optical fiber. The system is configured to provide access area organization and/or low profiles, such as through staggered tether lengths, tether webbing and/or access area sleeve arrangements.

Abstract: An optical fiber distribution system is provided. The system includes a distribution cable having a plurality of cable optical fibers. The system includes a plurality of optical fiber tethers each including a tether optical fiber optically coupled to a cable optical fiber. The tethers provide access to and distribute the optical network at positions along the length of the optical fiber. The system is configured to provide access area organization and/or low profiles, such as through staggered tether lengths, tether webbing and/or access area sleeve arrangements.

Abstract: An optic fiber branch distribution cable and system is provided. The branch distribution cable is pre-connectorized. The pre-connectorized branch distribution cable is configured for use in outdoor optical network installations. The branch distribution cable includes a pre-formed, head-end connectorized access point and a pre-formed, rear-end connectorized access point. Each access point includes one or more optical fiber tethers optically coupled at one end to an optical fiber of branch distribution cable and each includes an optical connector at the other end of the tether.

Abstract: An optic fiber branch distribution cable and system is provided. The branch distribution cable is pre-connectorized. The pre-connectorized branch distribution cable is configured for use in outdoor optical network installations. The branch distribution cable includes a pre-formed, head-end connectorized access point and a pre-formed, rear-end connectorized access point. Each access point includes one or more optical fiber tethers optically coupled at one end to an optical fiber of branch distribution cable and each includes an optical connector at the other end of the tether.

Abstract: An apparatus for controlling rotation of an outer sleeve member relative to an inner cylindrical duct member is used in a drilling system for controlling steering of a downhole drilling tool. The apparatus includes an annular swash plate pump and a stack of annular brake disks in the space between the members. The pump is driven by the rotation to pump fluid into a supply cylinder driving the brake. An orifice controls escape of the fluid from the chamber at a controlled rate. The rate is controlled to maintain a balance between the pumping rate and the brake pressure to keep the rotation at a required rate. The apparatus is used in the drilling system which includes a shallow bend in the drilling tool and a system for rotating the bent drilling tool slowly about a longitudinal axis of the drilling tool while the drill bit rotates more rapidly. The controlled orifice further allows the slow rotation to be halted at a predetermined orientation of the bend axis so as to effect a change in drilling direction.

Abstract: A method is provided for drilling of a well bore portion including a short radius curved section followed by a straight section. A drilling tool is provided having a first portion on which the drill bit is mounted and a second portion carrying the motor with a knuckle coupling therebetween. The short radius curved section is completed using the drilling tool with the knuckle coupling diverting to one side of the bore to steer the drill bit to the other side. After the curved section is complete the drilling is controlled in an accurately straight orientation by providing an eccentric collar which is attached onto the drilling tool at a position adjacent the knuckle portion. The eccentric collar holds the drilling tool at a slight angle less than that during the curved section. Simultaneously with the rotation of the drill bit, the drill string, the tool and the collar are rotated more slowly about the longitudinal axis so as to constantly vary the angle of attack of the drill bit.

Abstract: A drilling system for controlling steering of a downhole drilling tool includes a shallow bend in the drilling tool and a system for rotating the bent drilling tool slowly about a longitudinal axis of the drilling tool while the drill bit rotates more rapidly. The system further allows the slow rotation to be halted at a predetermined orientation of the bend axis so as to effect a change in drilling direction. The system for rotating and halting this slow rotation comprises a downhole swivel coupling between the drilling tool and the drill string so that torque from the drill bit tends to rotate the drilling tool in the opposite direction. A control device is provided to restrict the amount of torque communicated through the swivel coupling and to halt the swivel coupling as required to control the steering of the drill bit.

Abstract: A conventional well bore drilling system includes a coiled tubing mounted on a reel and connected to a mud supply for supplying mud through the tubing to a downhole end of the tubing to which is attached the downhole drilling tool. The system is modified by the addition of an inner tubing attached to the reel shaft and extending through the outer tubing to the drilling tool. The drilling mud is supplied in the space between the inner and outer tubes and a gas is supplied through the inner tube, The gas is vented through a coupling at the drilling tool into the well bore so as to enter the well bore and reduce the hydrostatic head of the fluids within the well bore to an under balanced condition below the pressure of the producing zone.

Abstract: A conventional drilling system using continuous coiled tubing connected to a reel at its upper end and connected to a drilling tool at its lower end is steered by rotating the injector at the well head which drives the tubing into the well about an axis longitudinal of the well bore to effect twist in the tubing along the well bore and thus to rotate the drilling tool. This twist in the tubing between the injector and the reel is negated by rotating the reel about a vertical axis parallel to the well bore in a direction, viewed from above, which is opposite to the direction of the injector.

Abstract: A lightweight block for interior partitions of buildings weighing less than one-half of any type of lightweight concrete block now manufactured, formed of a mixture of 10.66:1 ratio of expanded perlite aggregate and Portland cement, a water cement ratio of 6.66 gallons of water to 1 cubic foot of cement and an additive for making the mixture tractable, no other aggregate or binder being included.