Patents by Inventor Benjamin J. Darien

Benjamin J. Darien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10220045
    Abstract: Compositions and methods for preparing stabilized CSA compositions having reduced agglomeration and increased stability. The compositions have increased efficacy in killing microbes and reduced cytotoxicity to mammals. The compositions include a liquid carrier, micelles formed from an amphiphilic material, and CSA molecules encapsulated by the micelles. The CSA compositions can be formed by blending together a solvent or liquid carrier, a plurality of CSA molecules, and a micelle-forming agent and causing or allowing the micelle-forming agent to form micelles encapsulating at least a portion of the CSA molecules so that no more than 25% of the CSA molecules form agglomerates larger than 1 ?m in size. The CSA compositions can be used to treat mammals, such as mammals suffering from microbial diseases or infections.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: March 5, 2019
    Assignee: BRIGHAM YOUNG UNIVERSITY
    Inventors: Benjamin J. Darien, Paul B. Savage
  • Publication number: 20150258121
    Abstract: Compositions and methods for preparing stabilized CSA compositions having reduced agglomeration and increased stability. The compositions have increased efficacy in killing microbes and reduced cytotoxicity to mammals. The compositions include a liquid carrier, micelles formed from an amphiphilic material, and CSA molecules encapsulated by the micelles. The CSA compositions can be formed by blending together a solvent or liquid carrier, a plurality of CSA molecules, and a micelle-forming agent and causing or allowing the micelle-forming agent to form micelles encapsulating at least a portion of the CSA molecules so that no more than 25% of the CSA molecules form agglomerates larger than 1 ?m in size. The CSA compositions can be used to treat mammals, such as mammals suffering from microbial diseases or infections.
    Type: Application
    Filed: March 10, 2015
    Publication date: September 17, 2015
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Benjamin J. Darien, Paul B. Savage
  • Patent number: 8652546
    Abstract: Both liquid and dry form Morinda citrifolia enhanced animal food products are provided for increasing CD8+ T cell activation in new born animals. Both contain M. citrifolia fruit puree and other M. citrifolia plant products.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: February 18, 2014
    Assignee: Tahitian Noni International, Inc.
    Inventors: Benjamin J. Darien, Richard G. Godbee
  • Patent number: 7807636
    Abstract: A novel bovine P-selectin glycoprotein ligand-1 (bPSGL-1) is disclosed having the amino acid sequence set forth in SEQ. ID. NO:1. DNA sequences encoding the bPSGL-1 are also disclosed, along with vectors, host cells, and methods of using the bPSGL-1. The invention further provides methods for preventing or reducing acute inflammatory response in a bovine subject by administering bPSGL-1 and fragments thereof (e.g., a bPSGL-1 Ig fusion protein). The invention also provides methods for identifying compounds of reducing or preventing damage to tissue or organs caused by acute inflammatory response in a bovine.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: October 5, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Benjamin J. Darien
  • Publication number: 20090068204
    Abstract: Both liquid and dry form Morinda citrifolia enhanced animal food products are provided for increasing CD8+ T cell activation in new born animals. Both contain M. citrifolia fruit puree and other M. citrifolia plant products.
    Type: Application
    Filed: August 27, 2008
    Publication date: March 12, 2009
    Inventors: Benjamin J. Darien, Richard G. Godbee
  • Patent number: 7459523
    Abstract: A novel equine P-selectin glycoprotein ligand-1 (ePSGL-1) is disclosed having the amino acid sequence set forth in SEQ ID NO:2. DNA sequences encoding the ePSGL-1 are also disclosed, along with vectors, host cells, and methods of making the ePSGL-1. The invention further provides methods for preventing or reducing acute inflammatory response in an equine subject by administering ePSGL-1 and fragments thereof (e.g., an ePSGL-1-Ig fusion protein). The invention also provides methods for identifying compounds capable of reducing or preventing damage to tissue or organs caused by acute inflammatory response in an equine subject.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: December 2, 2008
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Benjamin J. Darien