Abstract: Disclosed herein are compounds that inhibit cullin-RING E3 ubiquitin ligase 4, a method of inhibiting the catalytic activity of a Cullin-RING E3 Ubiquitin (Ub) Ligase (CRL) in a cell, compositions comprising the inhibitor compounds, a method of treating a tumor, and a method of treating a subject for cancer.

Abstract: A system according to one embodiment includes a first computing device comprising ultra-wideband communication circuitry, and a second computing device comprising ultra-wideband communication circuitry configured to communicate with the ultra-wideband communication circuitry of the first computing device to determine the angle and distance of the first computing device relative to the second computing device.

Abstract: A method according to one embodiment includes receiving audio input by a microphone of an access control device that controls access through a passageway, processing an audio signal associated with the audio input to identify and authenticate a user, determining a command corresponding with the audio signal in response to identification and authentication of the user, and performing at least one action that corresponds with the command.

Abstract: A system according to one embodiment includes a first computing device comprising ultra-wideband communication circuitry, and a second computing device comprising ultra-wideband communication circuitry configured to communicate with the ultra-wideband communication circuitry of the first computing device to determine the angle and distance of the first computing device relative to the second computing device.

Abstract: An access control system and methods according to at least one embodiment leverage wireless access credentials to allow a user to securely gain access to a secured area using his or her mobile device. As such, a credentialed mobile device may permit access to the secured area without requiring a real-time connection to a credential management system and/or an administrative system.

Abstract: An access control system and methods according to at least one embodiment leverage wireless access credentials to allow a user to securely gain access to a secured area using his or her mobile device. As such, a credentialed mobile device may permit access to the secured area without requiring a real-time connection to a credential management system and/or an administrative system.

Abstract: A method according to one embodiment includes receiving audio input by a microphone of an access control device that controls access through a passageway, processing an audio signal associated with the audio input to identify and authenticate a user, determining a command corresponding with the audio signal in response to identification and authentication of the user, and performing at least one action that corresponds with the command.

Abstract: An access control system and methods according to at least one embodiment leverage wireless access credentials to allow a user to securely gain access to a secured area using his or her mobile device. As such, a credentialed mobile device may permit access to the secured area without requiring a real-time connection to a credential management system and/or an administrative system.

Abstract: A method according to one embodiment includes receiving audio input by a microphone of an access control device that controls access through a passageway, processing an audio signal associated with the audio input to identify and authenticate a user, determining a command corresponding with the audio signal in response to identification and authentication of the user, and performing at least one action that corresponds with the command.

Abstract: A system according to one embodiment includes a first computing device comprising ultra-wideband communication circuitry, and a second computing device comprising ultra-wideband communication circuitry configured to communicate with the ultra-wideband communication circuitry of the first computing device to determine the angle and distance of the first computing device relative to the second computing device.

Abstract: A method according to one embodiment includes receiving audio input by a microphone of an access control device that controls access through a passageway, processing an audio signal associated with the audio input to identify and authenticate a user, determining a command corresponding with the audio signal in response to identification and authentication of the user, and performing at least one action that corresponds with the command.

Abstract: An access control system and methods according to at least one embodiment leverage wireless access credentials to allow a user to securely gain access to a secured area using his or her mobile device. As such, a credentialed mobile device may permit access to the secured area without requiring a real-time connection to a credential management system and/or an administrative system.

Abstract: An access control system including a data storage device configured to store a master credential database having a plurality of master identifiers and master status codes, an access control device having a local credential database including a plurality of local identifiers, and an electronic credential including a credential identifier. The access control device is configured to receive the credential identifier from the electronic credential, to determine whether to perform an update based upon the local status code associated with the local identifier of the credential identifier, and to update data in the local credential database with data in the master credential database by way of communication with the data storage device in response to the determining.

Abstract: An access control system including a data storage device configured to store a master credential database having a plurality of master identifiers and master status codes, an access control device having a local credential database including a plurality of local identifiers, and an electronic credential including a credential identifier. The access control device is configured to receive the credential identifier from the electronic credential, to determine whether to perform an update based upon the local status code associated with the local identifier of the credential identifier, and to update data in the local credential database with data in the master credential database by way of communication with the data storage device in response to the determining.

Abstract: An access control system including a data storage device configured to store a master credential database having a plurality of master identifiers and master status codes, an access control device having a local credential database including a plurality of local identifiers, and an electronic credential including a credential identifier. The access control device is configured to receive the credential identifier from the electronic credential, to determine whether to perform an update based upon the local status code associated with the local identifier of the credential identifier, and to update data in the local credential database with data in the master credential database by way of communication with the data storage device in response to the determining.

Abstract: An access control system including a data storage device configured to store a master credential database having a plurality of master identifiers and master status codes, an access control device having a local credential database including a plurality of local identifiers, and an electronic credential including a credential identifier. The access control device is configured to receive the credential identifier from the electronic credential, to determine whether to perform an update based upon the local status code associated with the local identifier of the credential identifier, and to update data in the local credential database with data in the master credential database by way of communication with the data storage device in response to the determining.