Abstract: An instance secrets management isolated runtime environment is launched at a virtualization server, and utilizes a subset of memory assigned to a compute instance. The subset of memory is inaccessible from entities external to the runtime environment. A secrets manager of the runtime environment provides a security artifact to an application, running at the compute instance, which has requested access to a resource. The artifact is generated by the secrets manager using a security secret associated with the compute instance; the secret is not accessible to programs external to the runtime environment. In response to a determination that the artifact is valid, the application obtains access to the resource.

Abstract: Various embodiments of apparatuses and methods for multi-cast, multiple unicast, and unicast distribution of messages with time synchronized delivery are described. In some embodiments, the disclosed system and methods include a reference timekeeper providing a reference clock to one or more host computing devices. The one or more host computing devices host compute instances, and also contain respective isolated timing hardware outside the control of the compute instances. The isolated timing hardware of the one or more host computing devices then receive respective packets, and obtain the same time to deliver the respective packets. Each isolated timing hardware provides either the packet, or information to access the packet, to its respective destination compute instance subsequent to determining that the same specified time to deliver the packet has occurred. Thus, the respective packets are delivered near simultaneously to the one or more destination compute instances.

Abstract: Systems and methods are provided for highly accurate synchronization of machine instances in a distributed, hosted computing environment to a reference timekeeper. In addition to a general communication network accessible to machine instances, the distributed environment includes a second network dedicated to carrying time information, such as a pulse-per-second (PPS) signal to isolated timing hardware within host computing devices. The isolated timing hardware can use the PPS signal, along with a reference time, to set a hardware clock. The isolated timing hardware can further provide an interface to machine instances that enables the instances to read the time of the hardware clock. This configuration enables many instances can share access to a single reference timekeeper, thus synchronizing those instances to a much higher accuracy than in traditional network-based time protocols.

Abstract: Systems and methods are provided for highly accurate synchronization of machine instances in a distributed, hosted computing environment to a reference timekeeper. In addition to a general communication network accessible to machine instances, the distributed environment includes a second network dedicated to carrying time information, such as a pulse-per-second (PPS) signal to isolated timing hardware within host computing devices. The isolated timing hardware can use the PPS signal, along with a reference time, to set a hardware clock. The isolated timing hardware can further provide an interface to machine instances that enables the instances to read the time of the hardware clock. This configuration enables many instances can share access to a single reference timekeeper, thus synchronizing those instances to a much higher accuracy than in traditional network-based time protocols.

Abstract: Various embodiments of apparatuses and methods for multi-cast, multiple unicast, and unicast distribution of messages with time synchronized delivery are described. In some embodiments, the disclosed system and methods include a reference timekeeper providing a reference clock to one or more host computing devices. The one or more host computing devices host compute instances, and also contain respective isolated timing hardware outside the control of the compute instances. The isolated timing hardware of the one or more host computing devices then receive respective packets, and obtain the same time to deliver the respective packets. Each isolated timing hardware provides either the packet, or information to access the packet, to its respective destination compute instance subsequent to determining that the same specified time to deliver the packet has occurred. Thus, the respective packets are delivered near simultaneously to the one or more destination compute instances.

Abstract: Various embodiments of apparatuses and methods for trusted and/or attested packet timestamping are described. In some embodiments, the disclosed system and methods include a reference timekeeper providing a reference clock to host computing devices. The host computing devices host compute instances using a first set of computing resources, and also contain isolated timing hardware utilizing a different set of computing resources. The isolated timing hardware sets a hardware clock based on a signal corresponding to the reference clock from the reference timekeeper. The isolated timing hardware then receives a packet from a particular compute instance, creates a timestamp for the packet based at least in part on the hardware clock, where the timestamp is outside the control of the compute instances, and sends the packet and the timestamp through a data network to transmit to a packet destination.

Abstract: A watersports sandal is disclosed. The sandal has a flexible sole that underlies and protects a user's foot in a walking configuration. The sandal has a detachable forefoot strap that connects the sole to the user's forefoot and an ankle strap that connects the heel portion of the sole to the lower leg of the user. The sandal can be reconfigured to a stowed configuration in which the forefoot strap attaches the sole to a user's lower leg. In this stowed configuration, the user's bare feet are exposed to allow him fine sensitivity to water sport devices such as surf boards.

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: A method of preparing metal mesoporphyrin compounds is described. A metal mesoporphyrin compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: Methods of treating infant hyperbilirubinemia using stannsoporfin are disclosed. The methods of the invention permit treatment of various patient populations at lower doses of stannsoporfin than previously believed effective, providing advantages in therapeutic administration.

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: Water soluble tin mesoporphyrin compounds are described. Methods of preparation of water soluble metal mesoporphyrin compounds and pharmaceutical preparations are also described.

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract: A container defining an outer housing includes a base, a surrounding side wall structure extending upwardly from the base, and a top wall having a central opening therethrough exposing an interior chamber containing a liquid fuel supply, including diethylene glycol and an isoparaffin mixture. A fibrous material filled within the interior chamber is structured and disposed to hold and stabilize the diethylene glycol which fills pockets throughout the fibrous material to form a stabilized gel-like mass. An ignitor cord extending upwardly from the base within the interior chamber and through the central opening delivers the isoparaffin mixture by capillary action from a bottom of the interior chamber to an exterior, exposed portion of the ignitor cord to facilitate initial igniting thereof and subsequent igniting of the diethylene glycol on an upper exposed surface of the fibrous material.

Abstract: A cooking apparatus adapted to burn liquid fuel including a container defining an outer housing and having a base, a surrounding side walls structure, and top, the top having an opening therethrough in exposing relation to an interior chamber of the container wherein a fiberglass material is disposed in substantially filling relation and is structured to hold and regulate the movement of liquid fuel therein so as to prevent spillage of the liquid fuel from within the container, the liquid fuel being delivered to an upper exposed surface of the fiberglass material adjacent to the opening of the top by a braided fiberglass ignitor cord, which further facilitates igniting and provides for the continuous burning of the fuel at the upper exposed surface, and the fiberglass material being contained within the interior chamber by a retainer screen disposed in covering relation over the opening in the top of the container.