Abstract: The invention relates to a comb polymer having a polymer backbone and lateral side chains linked to the polymer backbone, wherein the lateral side chains comprise a) alkyl ether terminated polyalkylene oxide side chains, and b) tertiary amine-functional side chains, wherein the tertiary amine groups are at least partly neutralized by an acid having a molecular weight in the range of 100 g/mol to 2000 g/mol, wherein the molecular weight relates to the number average molecular weight Mn in the case of polymeric acids, and wherein the lateral side chains a) and b) are distributed in random order.

Abstract: The present invention relates to methods of determining the presence or absence of certain cancers in a human individual, as well as to related methods to determine the response to therapy against certain cancers in a human individual, in particular ovarian cancer in a woman. Such methods are based on the detection-from (eg cell-free) DNA of said human individual—of one or more methylated (or un-methylated) CpGs being associated with differentially methylated regions (DMRs) of the present invention; such as methylation (or un-methylation) at one or more or all of certain CpGs being associated with such DMRs. Accordingly, such methods have diagnostic, prognostic and/or predictive utility for detecting or managing certain cancers in women or men, in particular ovarian cancer in women.

Abstract: The invention relates to a non-pigmented composition comprising a) a block co-polymer comprising at least one first block and at least one second block which is different from the first block, wherein the first block comprises repeating units 1, repeating unit 1 and the second block comprises repeating units 2, repeating unit 2 wherein Z represents O or NH, R1 represents H or CH3, R2 represents a group selected from hydrocarbyl groups and ether group-containing groups, R3 represents an organic group having 2 to 4 carbon atoms, R4 and R5 independently represent an organic group, wherein R4 and R5 are optionally linked to each other to form a cyclic structure, and b) a polymer comprising at least one acidic group, and having a number average molecular weight of 300 g/mol or higher.

Abstract: The invention relates to a composition comprising a) a polymer a) comprising polymerized units of a N-vinyl lactam, b) a comb copolymer b) having a polymer backbone based on a vinyl aromatic compound and an ethylenically unsaturated polymerizable carboxylic anhydride, and having at least two polyalkylene oxide side chains, and c) a carbon-based material.

Abstract: The present invention relates to methods of identifying the presence of DNA from one or more metastatic breast cancer (mBC) cells in a sample from an individual. The invention also relates to methods of diagnosing metastatic breast cancer (mBC) by identifying the presence of mBC cell DNA in a sample from an individual. The invention also relates to methods of identifying a breast cancer patient as having a poor disease prognosis by identifying the presence of DNA from one or more mBC cells in a sample from an individual. The invention additionally relates to methods of identifying in DNA from an individual the presence of a methylation signature associated with mBC by identifying the presence of DNA from one or more mBC cells in a sample from an individual.

Abstract: A polar modulator arrangement has a first and a second node to receive a digital signal with a first and a second component corresponding to a digital amplitude component and a digital phase component. A digital interpolation filter generates an interpolated first component by interpolating and filtering the first component. A polar modulated radio frequency signal is generated by a combination element as a function of the interpolated first component and the second component.

Abstract: A polar modulator arrangement has a first and a second node to receive a digital signal with a first and a second component corresponding to a digital amplitude component and a digital phase component. A digital interpolation filter generates an interpolated first component by interpolating and filtering the first component. A polar modulated radio frequency signal is generated by a combination element as a function of the interpolated first component and the second component.