Patents by Inventor Benjamin M. Yeh
Benjamin M. Yeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240058721Abstract: The present invention provides a desktop toy, educational device, or stress relief device that provides visualization of the settling of dry fluidized powder and gas within a transparent container, where dynamic gas and powder streams may be seen flowing along the upper inclined side wall of the toy leading to a surface spout or eruption of gas and powder at the upper surface of the powder bed.Type: ApplicationFiled: June 23, 2023Publication date: February 22, 2024Inventor: Benjamin M. Yeh
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Publication number: 20220401587Abstract: The present invention provides a hollow borosilicate microparticle contrast media for use in CT imaging with shell material containing less than 8% oxides of non-silicon elements with atomic number greater than 10. In an exemplary embodiment, the invention provides an enteric contrast medium formulation which provides CT numbers distinct from those of water, soft tissue, and fat. In an exemplary embodiment, the invention provides an enteric contrast medium formulation that shows iodine concentrations less than 1.0 mg iodine/mL at dual energy CT or multi-energy CT image reformations. An exemplary formulation comprises, (a) an enteric contrast medium comprising a hollow borosilicate microparticle suspended in water. Exemplary hollow borosilicate microparticle has a true gravity between 0.1 and 0.4 g/cm3. In various embodiments, the hollow borosilicate microparticle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration.Type: ApplicationFiled: May 4, 2022Publication date: December 22, 2022Inventors: Benjamin M. YEH, Yuxin Sun
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Publication number: 20220233725Abstract: The present invention provides a silicon-based polymer contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising silicon-based polymer oil emulsified in water. Exemplary silicon-based polymer oil has a viscosity between about 50 cSt and 100,000 cSt. In various embodiments, the silicon-based polymer oil is emulsified with a vehicle or dispersing medium compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable vehicle in which the material is emulsified in the presence of a surfactant. In an exemplary embodiment, the silicon-based polymer comprises 30% or more of the weight of the contrast material formulation.Type: ApplicationFiled: April 18, 2022Publication date: July 28, 2022Inventors: Benjamin M. YEH, Yanjun Fu
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Publication number: 20220096030Abstract: The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended homogeneously. In an exemplary embodiment, the encapsulated gas or partial vacuum particle comprises 5% or more of the weight of the contrast material formulation.Type: ApplicationFiled: September 13, 2021Publication date: March 31, 2022Inventors: Benjamin M. Yeh, Yanjun Fu
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Publication number: 20210299284Abstract: Provided are MR images of a subject gastrointestinal tract structure in which the lumen of the structure is usefully darkened on both T1-weighted and T2-weighted images when the structure is imaged following administration to the subject of an enteric contrast agent formulation with particles containing encapsulated gas or partial vacuum. The present invention provides an encapsulated gas or partial vacuum particle contrast medium of use in acquiring such MR images. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water.Type: ApplicationFiled: August 9, 2019Publication date: September 30, 2021Inventor: Benjamin M. YEH
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Patent number: 11033640Abstract: The present invention provides particulate contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation based on particles of low-Z elements selected from microparticles and nanoparticles. In various embodiments, the particles are coated with a material compatible with enteric administration of the formulation to a subject in need of such administration. The invention also provides methods for imaging of body parts simultaneously enhanced with contrast media of the invention and with other contrast media of a different type using CT imaging, including dual energy or spectral CT imaging. The invention also provides methods for the digital separation of CT signal produced by the contrast media of the invention from the CT signal produced by other contrast media or bodily tissues, to generate multiple resultant CT images with individual contrast materials subtracted or highlighted.Type: GrantFiled: March 17, 2014Date of Patent: June 15, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Benjamin M. Yeh, Yanjun Fu, Tejal Desai
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Publication number: 20190070319Abstract: The present invention provides a silicon-based polymer contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising silicon-based polymer oil emulsified in water. Exemplary silicon-based polymer oil has a viscosity between about 50 cSt and 100,000 cSt. In various embodiments, the silicon-based polymer oil is emulsified with a vehicle or dispersing medium compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable vehicle in which the material is emulsified in the presence of a surfactant. In an exemplary embodiment, the silicon-based polymer comprises 30% or more of the weight of the contrast material formulation.Type: ApplicationFiled: September 10, 2018Publication date: March 7, 2019Inventors: Benjamin M. YEH, Yanjun FU
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Publication number: 20180110492Abstract: The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended homogeneously. In an exemplary embodiment, the encapsulated gas or partial vacuum particle comprises 5% or more of the weight of the contrast material formulation.Type: ApplicationFiled: April 20, 2016Publication date: April 26, 2018Inventors: Benjamin M. YEH, Yanjun FU
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Publication number: 20160193366Abstract: The present invention provides a silicon-based polymer contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising silicon-based polymer oil emulsified in water. Exemplary silicon-based polymer oil has a viscosity between about 50 eSt and 100,000 eSt. In various embodiments, the silicon-based polymer oil is emulsified with a vehicle or dispersing medium compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable vehicle in which the material is emulsified in the presence of a surfactant. In an exemplary embodiment, the silicon-based polymer comprises 30% or more of the weight of the contrast material formulation.Type: ApplicationFiled: August 18, 2014Publication date: July 7, 2016Inventors: Benjamin M. YEH, Yanjun FU
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Patent number: 9082211Abstract: In various embodiments, systems and methods can provide accurate measurements of blood flow dynamics in a subject. Projection data acquired during a computed tomography (CT) scan of the subject can be used to determine information representing inflow of a contrast material. Accordingly, a measurement of flow velocity, in addition to other aspects of flow, may be obtained from the projection data.Type: GrantFiled: May 6, 2010Date of Patent: July 14, 2015Assignee: The Regents of the University of CaliforniaInventors: Sven Prevrhal, Jean Rinkel, Carlos Forsythe, Benjamin M. Yeh
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Publication number: 20140276021Abstract: The present invention provides particulate contrast media for use in CT imaging. The contrast media are based on particles of low-Z elements. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising essentially water-insoluble particles of a material selected from microparticles and nanoparticles. Exemplary particles comprise a material comprising a plurality of atoms of an element with an atomic number from 6 to 52. In various embodiments, the particles are coated with a material compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast medium is incorporated into a pharmaceutically acceptable vehicle in which the particles are suspended.Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Inventors: Benjamin M. YEH, Yanjun FU, Tejal DESAI
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Publication number: 20110274333Abstract: In various embodiments, systems and methods can provide accurate measurements of blood flow dynamics in a subject. Projection data acquired during a computed tomography (CT) scan of the subject can be used to determine information representing inflow of a contrast material. Accordingly, a measurement of flow velocity, in addition to other aspects of flow, may be obtained from the projection data.Type: ApplicationFiled: May 6, 2010Publication date: November 10, 2011Inventors: Sven Prevrhal, Jean Rinkel, Carlos Forsythe, Benjamin M. Yeh