Abstract: This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.

Abstract: A message processing facility is described. The facility receives user input defining a textual message intended for an addressee service principal. Before sending the defined textual message, the facility analyzes the defined textual message to determine a textual message category to which the defined textual message belongs among a plurality of textual message categories.

Abstract: The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an altered GAPDH, expressing a variant glutamate dehydrogenase (gdh), aspartate semialdehyde dehydrogenase (asd), dihydropicolinate reductase (dapB), and meso-diaminopimelate dehydrogenase (ddh), expressing a novel nicotinamide nucleotide transhydrogenase, expressing a novel threonine aldolase, and expressing or modulating the expression of a pyruvate carboxylase in the host cells.

Abstract: Improved production of threonine from E. coli by fermentation is accomplished by attenuation but not elimination of the expression of either or both of the yafV gene encoding omega-amidase (a.k.a. 2-oxoglutaramate amidase). In certain embodiments the strain also has attenuated expression of the ilvA gene encoding threonine dehydratase (a.k.a threonine deaminase) in cases where there is attenuated express of the ilvA gene there is no need to express an exogenous cimA gene. In examples of both cases, attenuation is accomplished by engineering these genes to contain a weaker ribosome site. Further improvements in threonine production are made by expression of a heterologous pyruvate carboxylase gene exemplified by expression of the Corynebacterium glutamicum pyc gene under control of an E. coli promoter, to provide expression of pyruvate carboxylase that is not naturally expressed in E. coli. Still further improvement is accomplished by overexpression of the rhtC gene encoding the E.

Abstract: The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an altered GAPDH, expressing a variant glutamate dehydrogenase (gdh), aspartate semialdehyde dehydrogenase (asd), dihydropicolinate reductase (dapB), and meso-diaminopimelate dehydrogenase (ddh), expressing a novel nicotinamide nucleotide transhydrogenase, expressing a novel threonine aldolase, and expressing or modulating the expression of a pyruvate carboxylase in the host cells.

Abstract: The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an altered GAPDH, expressing a variant glutamate dehydrogenase (gdh), aspartate semialdehyde dehydrogenase (asd), dihydropicolinate reductase (dapB), and meso-diaminopimelate dehydrogenase (ddh), expressing a novel nicotinamide nucleotide transhydrogenase, expressing a novel threonine aldolase, and expressing or modulating the expression of a pyruvate carboxylase in the host cells.

Abstract: The present disclosure provides a HTP microbial genomic engineering platform for Saccharopolyspora spp. that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition.

Abstract: A mine tunnel support system of the type comprising spaced interconnected support sections is described. The support system is advanced along the tunnel in the forward direction in which mining is proceeding. Bolting machines may be carried on the support sections. A drill may be provided on one section and a bolt inserter provided on a section rearwardly thereof. As the system is advanced, the bolt inserter can insert a bolt into a hole previously formed by the drill. The operation of providing roof bolts is therefore split into a number of stages. A mechanism for erecting and/or pre-stressing permanent arch supports may be provided at the rear of the sections.

Abstract: A mine tunnel support system of the type comprising spaced interconnected support sections is described. Each section includes at least one bearing member which, when the section is in the first, loaded state, bears against the roof of the tunnel. Drive means are provided for changing the location of each support section when in the non-loaded state. The support system is advanced along the tunnel in the forward direction in which mining is proceeding by bringing each section sequentially into the non-loaded state, commencing with that at the rear, moving the section with the drive means into proximity with the next forward section, and thereafter returning the section to the loaded state. Bolting machines may be carried on the support sections. A drill may be provided on one section and a bolt inserter provided on a section rearwardly thereof. As the system is advanced, the bolt inserter can insert a bolt into a hole previously formed by the drill.

Abstract: A joint member or fishplate intended to join together two lengths of I-Section beams at an angle one to the other. The fishplate comprising two arms including a predetermined angle and joined by a central portion having an outwardly projecting block, the sides of which extend outwardly perpendicular to the axes of the respective arms. This enables the mating ends of the two beams to be cut perpendicular to their axes and when joined together by a fishplate, the bottom flanges of the two beams abut or nearly abut and the top flanges are separated by a distance, depending upon the angle at which the beams are being joined, and which corresponds to the length of the outwardly projecting block. The ends of the top flanges of the beams then contact the sides of the outwardly extending block to form a strong joint.

Abstract: An improved bending machine with three rollers which may be driven at different speeds and/or with differing torques. A control system receives signals indicative of the position and speed of rotation of one or more of the rollers. The control system is connected to a mechanism for adjusting the position, rotational speed and torque of at least one roller so that commands can be given to vary these parameters. Thus, the machine can be readily and accurately adjusted to produce bends of differing dimension in a strip workpiece.

Abstract: A method and apparatus for producing a bore hole lining from a number of pre-formed shells is described. The shells are assembled on a lower frame which is lowered into the bore hole by a predetermined distance in a series of steps, each step being of a length corresponding to the depth of each shell loaded, the frame being lowered after each shell is assembled thereon. The frame and batch of assembled shells so formed is then lowered to the lowest unlined portion of the bore hole. Grout is poured around the shells and allowed to set and the lower frame is detached from the batch and withdrawn. This method and apparatus allows relatively long bores to be lined.

Abstract: The invention relates to the lining of bore holes with cement or the like by apparatus designed to spray cement directly on to the raw face of the hole. Such apparatus in accordance with the invention comprises a spray head, means to drive the head through the hole and means for delivering cement to the head characterized in that the head has an annular chamber into which cement is fed and from which colloidal cement is fed in an annular ring to a rotatable spray disc or arm which is arranged to distribute the cement substantially evenly over the internal surface of the hole.The annular feed enables even spray to take place while avoiding problems associated with axle feeding.