Patents by Inventor Benjamin P. Chen

Benjamin P. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis virus sentinel virus I (SVI)
    Publication number: 20030198947
    Abstract: The invention relates to a new group of viruses, designated SVI. Isolated SVI viruses, polynucleotides and proteins from SVI viruses, and antibodies which bind SVI virus and SVI viral proteins are provided. The polynucleotides, proteins, and antibodies of the invention may be used to detect SVI virus or infection by SVI virus in a susceptible individual. Additionally, polynucleotides of the invention may be inserted into recombinant expression vectors recombinant production of viral proteins.
    Type: Application
    Filed: June 3, 2003
    Publication date: October 23, 2003
    Inventors: Jen-Kuei Liu, Roy A. Bohenzky, Yu-Huei Lin, Benjamin P. Chen
  • Sentinel virus II
    Publication number: 20030165540
    Abstract: The invention relates to a new virus, designated H101.c33 or Sentinel Virus II (SVII). Isolated SVII viruses, polynucleotides and proteins from SVII viruses, and antibodies which bind SVII virus and SVII viral proteins are provided. The polynucleotides, proteins, and antibodies of the invention may be used to detect SVII virus or infection by SVII virus in a susceptible individual. Additionally, polynucleotides of the invention may be inserted into recombinant expression vectors for recombinant production of viral proteins.
    Type: Application
    Filed: May 4, 2001
    Publication date: September 4, 2003
    Inventors: Jen-Kuei Liu, Samantha Lewis, Hans-Georg Batz, Latha Ramaswamy, Roy Bohenzky, Yu-Huei Lin, Janine Montiel, Benjamin P. Chen
  • Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice
    Patent number: 6455756
    Abstract: Immunocompromised mammalian hosts are sub-cutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up to 9 months in vivo when supplied with an allogeneic human fetal thymic fragment at the same site. Grafts contain cell populations expressing CD4 and CD8, CD19 or CD33, CD14 and CD15, all of which also express the HLA type of the fetal bone/spleen. T-cells derived from progenitors in the fetal bone/spleen contain both mature single positive CD4+CD8−, CD8+CD4− as well as a high percentage of immature double positive CD4+CD8+ populations.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: September 24, 2002
    Assignee: Novartis AG
    Inventors: Benjamin P. Chen, Christopher C. Fraser
  • Hepatitis virus sentinel virus I (SVI)
    Publication number: 20010034018
    Abstract: The invention relates to a new group of viruses, designated SVI. Isolated SVI viruses, polynucleotides and proteins from SVI viruses, and antibodies which bind SVI virus and SVI viral proteins are provided. The polynucleotides, proteins, and antibodies of the invention may be used to detect SVI virus or infection by SVI virus in a susceptible individual. Additionally, polynucleotides of the invention may be inserted into recombinant expression vectors recombinant production of viral proteins.
    Type: Application
    Filed: December 8, 2000
    Publication date: October 25, 2001
    Inventors: Jen-Kuei Liu, Roy A. Bohenzky, Yu-Huei Lin, Benjamin P. Chen
  • Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereof
    Patent number: 6127135
    Abstract: This invention provides a novel antibody, designated the .alpha.EM10 antibody. Also provided are methods of determining hematopoietic stem cell content. The methods employ using antibodies (.alpha.EM10) specific for a unique cell marker (EM10) that is expressed on stem cells.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: October 3, 2000
    Inventors: Beth Louise Hill, Elen Rozler, Benjamin P. Chen
  • Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereof
    Patent number: 5814440
    Abstract: This invention provides a novel antibody, designated .alpha.EM10, and a hybridoma cell line that produces the .alpha.EM10 antibody. Also provided are methods to obtain compositions enriched for hematopoietic stem cells. The methods employ a separation technique utilizing antibodies (.alpha.EM10) specific for a unique cell marker (EM10) that is expressed on stem and progenitor cells, while being less accessible or absent on more mature cells. Further provided are cell compositions enriched for EM10+ cells.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: September 29, 1998
    Assignee: Systemix, Inc.
    Inventors: Beth Louis Hill, Elen Rozler, Benjamin P. Chen
  • Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
    Patent number: 5677136
    Abstract: A method for obtaining human hematopoietic stem cells is provided by enrichment for stem cells using a novel stem cell marker. Compositions enriched for stem cells are obtained using novel antibody HCC-1 which is specific for a CD59 epitope highly accessible on stem cells, and less accessible or absent on mature cells. The enriched population of cells derived from these methods are also provided.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: October 14, 1997
    Assignee: Systemix, Inc.
    Inventors: Paul J. Simmons, Beth L. Hill, Benjamin P. Chen
  • Wearable device with graphical user interface
    Patent number: D1022714
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: April 16, 2024
    Assignee: Apple Inc.
    Inventors: Jody Akana, Molly Anderson, Bartley K. Andre, Shota Aoyagi, Anthony Michael Ashcroft, Marine C. Bataille, Jeremy Bataillou, Kevin Will Chen, Andrew Patrick Clymer, Clara Geneviève Marine Courtaigne, Markus Diebel, Alan C. Dye, Aurelio Guzmán, M. Evans Hankey, Julian Hoenig, Richard P. Howarth, Jonathan P. Ive, Julian Jaede, Duncan Robert Kerr, Aaron Mathew Melim, Marc A. Newson, Peter Russell-Clarke, Benjamin Andrew Shaffer, Joe Sung-Ho Tan, Clement Tissandier, Jacob Weiss, Eugene Antony Whang, Rico Zörkendörfer