Abstract: Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.

Abstract: The invention relates to an ophthalmological implant (100) with an optically imaging element (110), a digital product identifier (130) being arranged on the optically imaging element. The invention additionally relates to a corresponding method for producing the implant and to a machine reading system (200) for detecting and decoding the digital product identifier. The aim of the invention is to provide an ophthalmological implant and a method for producing same, said method allowing a unique and complete product identifier and a check thereof using simple means at any point in time. This is achieved by an ophthalmological implant with a digital product identifier (130) which is implemented by means of an encoded point grid (135) of identifier points (57), said point grid being machine-readable in the visible light range and having one irregular semi-random character.

Abstract: An intraocular lens has an optic body, a haptic element mounted on the optic body and having a haptic curvature and a plurality of recesses on the side of the haptic element facing the optic body, a first actuator configured to reversibly change the haptic curvature of the haptic element such that the haptic element is moved away from the optic body from a rest position, a brace arm mounted on the optic body and the longitudinal brace arm end which is configured to be provided a recess when the haptic element is in the rest position, and a second actuator configured to reversibly change, with a change in a property of the second actuator, a brace arm curvature of the brace arm such that the recess in which the longitudinal brace arm end is to be provided can be adjusted with the property of the second actuator.

Abstract: An accommodative intraocular lens includes a first lens part, a haptic, and a flexible membrane. The flexible membrane is arranged adjacent to a distal optical body surface, delimits a cavity together with the distal optical body surface and is transparent to light. A second lens part has a hollow cylinder coupled releasably to the first lens part, as a result of which the intraocular lens can be brought into a coupling state in which the second lens part is arranged on a distal side of the first lens part and the hollow cylinder is configured to deform the membrane by a longitudinal displacement of the hollow cylinder parallel to the optical axis. The hollow cylinder has on its exterior an outer face and a bearing face arranged adjacent to a proximal end of the outer face and encloses, with the outer face, an angle of less than 180°.

Abstract: An eye lens having a front lens element and a rear lens element, which each have a positive optical power and an optical region, and an intermediate element, which is connected to the lens elements outside the optical regions so that the lens elements and the intermediate element form a cavity. The eye lens allows the width of an access incision necessary for implantation to be reduced. The eye lens includes the lens elements and the intermediate element that are shaped such that, in the implanted state, a distance between the front lens element and the rear lens element is fixed and the cavity has an opening which allows liquid to flow into the cavity. Embodiments of the invention include a method for producing such an eye lens and a method for implantation.

Abstract: A method for producing an accommodative intraocular lens includes providing first and second components and a support body with an interior space and open to the top, fastening the first component to the support body, generating pressure which is higher in the exterior space than in the interior space such that the first component deforms downward, producing an adhesive surface on the upper side of the first component and/or on the second component, applying a liquid to the first component from above into the latter's downwardly deformed region, the liquid at no time contacting the adhesive surface, fastening the second component to the first component with the adhesive surface, as a result of which the accommodative intraocular lens is formed and the liquid is encapsulated with the first component and the second component in a cavity arranged in the interior of the intraocular lens.

Abstract: A method for producing an accommodative intraocular lens includes providing first and second components and a support body with an interior space and open to the top, fastening the first component to the support body, generating pressure which is higher in the exterior space than in the interior space such that the first component deforms downward, producing an adhesive surface on the upper side of the first component and/or on the second component, applying a liquid to the first component from above into the latter's downwardly deformed region, the liquid at no time contacting the adhesive surface, fastening the second component to the first component with the adhesive surface, as a result of which the accommodative intraocular lens is formed and the liquid is encapsulated with the first component and the second component in a cavity arranged in the interior of the intraocular lens.

Abstract: An acetaldehyde screening method is developed by feeding solid polymer sample particles having a free acetaldehyde (“AA”) content of 2 ppm or less, melting at least a portion of the sample particles to obtain a polymer sample having a heat history, and thereafter measuring the amount of acetaldehyde present in the polymer sample having the heat history. There is also provided a screening method in which the quantity of free or residual AA in or on a polymer sample is measured to obtain a first value AAf, the sample is melted, and thereafter the amount of AA generated upon remelting the polymer is measured to obtain a second value AAg.