Patents by Inventor Benjamin Tiemann
Benjamin Tiemann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11975237Abstract: The present invention relates to a respiratory therapy system having two respiratory therapy devices operable separately and independently of one another. The respiratory therapy devices each have a control unit and each have a device component controllable by means of the control unit for providing a device function. In this case, a coupling unit is provided for establishing an operational connection between the respiratory therapy devices. The coupling unit is designed for the purpose of controlling the control units of the respiratory therapy devices when the operational connection is established.Type: GrantFiled: December 20, 2018Date of Patent: May 7, 2024Assignee: LOEWENSTEIN MEDICAL TECHNOLOGY S.A.Inventors: Bjoern Tiemann, Christof Goebel, Anne Wonsyld, Thomas Ress, Benjamin Adametz, Jan Schattner
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Patent number: 11940427Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current.Type: GrantFiled: September 20, 2021Date of Patent: March 26, 2024Assignee: Roche Diagnostics Operations, Inc.Inventors: Benjamin Tiemann, Stefan Quint, Florian Schweinberger
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Publication number: 20230326729Abstract: A method for optimizing at least one parameter setting of at least one mass spectrometry device (110) operating at unit resolution is disclosed.Type: ApplicationFiled: June 12, 2023Publication date: October 12, 2023Inventors: Benjamin Tiemann, Daniel Intelmann
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Publication number: 20220319827Abstract: A method for multiple transition monitoring of at least one analyte in a sample using a quadrupole mass analyzer is provided and comprises at least one voltage application step, wherein a direct current (DC) voltage and a radio frequency (AC) voltage are applied between two pairs of electrodes of at least one mass filter of the analyzer, wherein the AC voltage has an amplitude VAC and the DC voltage has an applicable voltage VDC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage, wherein an amplitude ?VDC of the supplementary AC voltage is ? V DC , max 2 b + 1 , wherein VDC,max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board of the mass filter of the analyzer; and wherein at least one transition of the analyte is determined with at least one detector of the analyzer.Type: ApplicationFiled: June 6, 2022Publication date: October 6, 2022Applicant: Roche Diagnostics Operations, Inc.Inventors: Stefan QUINT, Florian SCHWEINBERGER, Benjamin TIEMANN
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Publication number: 20220128531Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current.Type: ApplicationFiled: September 20, 2021Publication date: April 28, 2022Applicant: Roche Diagnostics Operations, Inc.Inventors: Benjamin Tiemann, Stefan Quint, Florian Schweinberger
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Patent number: 11287402Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.Type: GrantFiled: December 7, 2020Date of Patent: March 29, 2022Assignee: Roche Diagnostics Operations, Inc.Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
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Patent number: 11249059Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.Type: GrantFiled: August 14, 2020Date of Patent: February 15, 2022Assignee: Roche Diagnostics Operations, Inc.Inventors: Stefan Quint, Benjamin Tiemann, Florian Schweinberger, Martin Stingl
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Publication number: 20210181166Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.Type: ApplicationFiled: December 7, 2020Publication date: June 17, 2021Applicant: Roche Diagnostics Operations, Inc.Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
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Patent number: 11016098Abstract: A method and an apparatus for determining a concentration of a target analyte in a sample of bodily fluid are disclosed. The method involves providing a sample of bodily fluid including the target analyte, providing an internal standard solution including a mixture of components having a plurality of isotopes of the target analyte, wherein a concentration of each isotope is unknown, adding the internal standard solution to the sample, analyzing the sample including the internal standard solution using a mass spectrometer, creating a sample function curve based on signal intensities, wherein the signal intensities define arbitrary units, transferring an analyte signal into a corresponding arbitrary analyte unit by means of the sample function curve, and transferring the arbitrary analyte unit into the concentration of a target analyte by means of a standardization function representing a curve of concentrations depending on the arbitrary units.Type: GrantFiled: October 12, 2018Date of Patent: May 25, 2021Assignee: Roche Diagnostics Operations, Inc.Inventors: Uwe Kobold, Roland Thiele, Noah Weiss, Benjamin Tiemann
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Publication number: 20210063361Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.Type: ApplicationFiled: August 14, 2020Publication date: March 4, 2021Applicant: Roche Diagnostics Operations, Inc.Inventors: Stefan Quint, Benjamin Tiemann, Florian Schweinberger, Martin Stingl
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Publication number: 20210063363Abstract: A method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer is provided including automatically monitoring a system pressure of an injection assembly of the liquid chromatography stream to generate a time series of system pressures, classifying the time series in one of two or more predetermined classes indicating different states of the LC stream and triggering a response based on the classification result.Type: ApplicationFiled: August 18, 2020Publication date: March 4, 2021Applicant: Roche Diagnostics Operations, Inc.Inventors: Marc Kaminski, Stefan Quint, Benjamin Tiemann
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Patent number: 10864200Abstract: The present description relates to a liquid composition having at least one immune-modulatory macrolide compound and an essentially cell-free blood hemolysate. The present description further relates to a method for manufacturing a stabilized immune-modulatory macrolide calibration solution, by a) preparing a solution comprising an essentially cell-free blood hemolysate, b) admixing a predetermined amount of at least one immune-modulatory macrolide into said solution comprising an essentially cell-free blood hemolysate, and, thereby c) manufacturing a stabilized immune-modulatory macrolide calibration solution. Furthermore, the present description relates to kits, uses, devices, methods and to an immune-modulatory macrolide compound calibration solution related thereto.Type: GrantFiled: September 6, 2019Date of Patent: December 15, 2020Assignee: Roche Diagnostics Operations, Inc.Inventors: Ewelina Hegel, Hans-Peter Josel, Eloisa Lopez-Calle, Josef Roedl, Noah Weiss, Benjamin Tiemann
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Publication number: 20190388402Abstract: The present description relates to a liquid composition having at least one immune-modulatory macrolide compound and an essentially cell-free blood hemolysate. The present description further relates to a method for manufacturing a stabilized immune-modulatory macrolide calibration solution, by a) preparing a solution comprising an essentially cell-free blood hemolysate, b) admixing a predetermined amount of at least one immune-modulatory macrolide into said solution comprising an essentially cell-free blood hemolysate, and, thereby c) manufacturing a stabilized immune-modulatory macrolide calibration solution. Furthermore, the present description relates to kits, uses, devices, methods and to an immune-modulatory macrolide compound calibration solution related thereto.Type: ApplicationFiled: September 6, 2019Publication date: December 26, 2019Applicant: Roche Diagnostics Operations, Inc.Inventors: Ewelina Hegel, Hans-Peter Josel, Eloisa Lopez-Calle, Josef Roedl, Noah Weiss, Benjamin Tiemann
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Publication number: 20190049460Abstract: A method and an apparatus for determining a concentration of a target analyte in a sample of bodily fluid are disclosed. The method involves providing a sample of bodily fluid including the target analyte, providing an internal standard solution including a mixture of components having a plurality of isotopes of the target analyte, wherein a concentration of each isotope is unknown, adding the internal standard solution to the sample, analyzing the sample including the internal standard solution using a mass spectrometer, creating a sample function curve based on signal intensities, wherein the signal intensities define arbitrary units, transferring an analyte signal into a corresponding arbitrary analyte unit by means of the sample function curve, and transferring the arbitrary analyte unit into the concentration of a target analyte by means of a standardization function representing a curve of concentrations depending on the arbitrary units.Type: ApplicationFiled: October 12, 2018Publication date: February 14, 2019Applicant: Roche Diagnostics Operations, Inc.Inventors: Uwe Kobold, Roland Thiele, Noah Weiss, Benjamin Tiemann