Abstract: Techniques regarding detecting one or more defined nucleic acid sequences are provided. For example, one or more embodiments described herein can comprise a method, which can comprise adding a molecular probe to a sample fluid comprising a first deoxyribonucleic acid segment and a second deoxyribonucleic acid segment. The molecular probe can have an affinity to bond to a defined nucleic acid sequence. The method can also comprise separating, via a nanoscale deterministic lateral displacement array, the first deoxyribonucleic acid segment from the second deoxyribonucleic acid segment based on a size of the first deoxyribonucleic acid segment.

Abstract: Techniques regarding screening for mutations using nanoscale deterministic arrays are provided. For example, one or more embodiments described herein can comprise a method, which can comprise cleaving a deoxyribonucleic acid segment hybridized with a molecular probe to form a sample fluid. The cleaving can occur at a first end and a second end of the molecular probe. Also, the cleaving can comprise a cleaving agent that targets base pair mismatches. The method can also comprise supplying the sample fluid to a nanoscale deterministic lateral displacement array to screen for a single nucleotide polymorphism.

Abstract: A method of purifying nucleic acid polymers for next generation sequencing includes loading a mixture of adapter ligated, fragmented nucleic acid polymers onto a nano-deterministic lateral displacement (nanoDLD) array. The mixture includes a first adapter ligated, fragmented nucleic acid polymer, a second adapter ligated, fragmented nucleic acid polymer, and a contaminant. The method further includes flowing the mixture through the nanoDLD array to separate the first adapter ligated, fragmented nucleic acid polymer from the second adapter ligated, fragmented nucleic acid polymer, and each of the first and second adapter ligated, fragmented nucleic acid polymers from the contaminant.

Abstract: A fluidic processor device and a wafer including the same, the device including a nanofluidic separator chip including a nanoDLD array, a housing for housing the chip including a top plate disposed on a topside of the chip, a bottom plate disposed on a backside of the chip and fastened to the top plate, and a spacer disposed between the chip and the bottom plate to create a clearance between the chip and the bottom plate for forming a drain space on the backside of the chip.

Abstract: This invention provides a method for increasing the activity of catalysts. The method requires the introduction of the catalyst into nano-structured surfaces. The catalysts are introduced as functional groups in molecules forming a monolayer on a surface. A mixed monolayer of catalyst and inert molecules generates ordered domains of molecules on the surface. The catalyst is confined in regions of 0.5 nm to 3 nm in size and is surrounded by an inert material. The presence of such ordered domains that commensurate in size with the reactants, enhance the performance of the catalyst and increase the rate of the reaction.

Abstract: This invention provides a method for increasing the activity of catalysts. The method requires the introduction of the catalyst into nano-structured surfaces. The catalysts are introduced as functional groups in molecules forming a monolayer on a surface. A mixed monolayer of catalyst and inert molecules generates ordered domains of molecules on the surface. The catalyst is confined in regions of 0.5 nm to 3 nm in size and is surrounded by an inert material. The presence of such ordered domains that commensurate in size with the reactants, enhance the performance of the catalyst and increase the rate of the reaction.