Abstract: Disclosed herein are methods and systems for reducing pain and/or providing an analgesic effect, using the administration of ultra-low radio frequency energy (ulRFE®). In some embodiments, ulRFE® is administered using the EMulate Voyager system. In some embodiments, the system comprises a battery-operated controller, an electromagnetic coil, and a battery charger. In some of these embodiments the system utilizes a single signal. In other embodiments, the system utilizes two or more signals, each signal derived from a different molecule. In some of the other embodiments, one or more of the signals are derived from the same molecule. In some embodiments, the system utilizes three or more signals derived from three or more different molecules, e.g., three signals, four signals, five signals, or more.

Abstract: Systems and methods for producing physiological effects in response to simulated stimuli on living organisms are disclosed herein. In one example, a non-intrusive delivery of drug-simulating signals causes physiological effects on a living organism.

Abstract: Disclosed herein are methods and systems for treating cancer including glioblastoma, recurrent glioblastoma, or newly diagnosed glioblastoma, using the administration of ultra-low radio frequency energy (ulRFE®), either alone or in combination with one or more conventional cancer therapies. In some embodiments, the one or more conventional cancer therapies include chemotherapy or an anti-angiogenic therapy or other therapies.

Abstract: Method and apparatus for generating and selecting low-frequency time-domain signals capable of transducing a mammalian system, to produce an agent-specific effect on the system, are disclosed. Low-frequency time-domain signals are generated in the presence of an injected magnetic stimulus, and the resulting signals are selected by a scoring algorithm, and optionally, by testing each signal identified by the scoring algorithm for its ability to produce an agent-specific response in a in vitro system containing components that are responsive to the agent. The selected signals are used to transduce the mammalian system by applying the signals to an electromagnetic transduction coil that holds the sample.