Patents by Inventor Benoît Flan

Benoît Flan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR INACTIVATING A PRION PROTEIN
    Publication number: 20160089422
    Abstract: The invention relates to a process for inactivating pathological prion proteins (PrPsc) in a sample or a material which may be contaminated by a pathological prion protein, wherein the sample or the material which may be contaminated by a pathological prion protein is put into contact with at least one methionine sulfoxide reductase.
    Type: Application
    Filed: May 15, 2014
    Publication date: March 31, 2016
    Inventors: Abdessatar Sami Chtourou, Benoît Flan
  • METHOD OF DETECTION AND/OR TITRATION IN VITRO OF AN UNCONVENTIONAL TRANSMISSIBLE AGENT
    Publication number: 20110151476
    Abstract: The invention relates to an in vitro method for the in vitro detection and/or titration of a non-conventional transmissible agent (NCTA) or of a protein of pathological conformation, which is a marker for infectiousness related to the NCTA, in a sample, comprising: replication or propagation, in cells in culture, of the NCTA present in the sample, and then repeated incubation with a substrate which allows amplification of the NCTA or of the protein of pathological conformation, nonpathological conformer of the NCTA, before determination of the presence and/or of the amount of the NCTA or of the protein of pathological conformation in the sample.
    Type: Application
    Filed: March 25, 2009
    Publication date: June 23, 2011
    Applicants: LFB-Biotechnologies, Institut National de la Recherche Agronomique
    Inventors: Benoit Flan, bruno You
  • Method for the in vitro titration of an NCTA application thereof in a method for the evaluation and/or monitoring of a biological product production method
    Patent number: 7727728
    Abstract: The invention relates to a method for the in vitro titration of a non-conventional transmissible agent (NCTA), using transgenic cell lines. The invention also relates to: the application of the aforementioned in vitro titration method in a method for the in vitro evaluation and/or monitoring of the effectiveness of a biological production or treatment method or of one or more steps in such a method for the elimination of an NCTA, and to the application thereof in a method for the in vitro evaluation and/or monitoring of a decontamination procedure.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: June 1, 2010
    Assignee: Laboratoire Francais du Fractionnement et des Biotechnologies
    Inventors: Jean-Thierry Aubin, Benoît Flan
  • Synthetic and standardized prion infectuous material, and uses thereof as an injecting inoculum
    Publication number: 20090081781
    Abstract: The invention concerns a novel, synthetic, standardised, soluble, reproducible and easy-to-handle infectious material of the prion type, consisting of a cell lysate or culture supernatant from stable transgenic cells expressing a prion protein PrP and supporting replication of the pathogenic form, PrPsc, of the said Prp.
    Type: Application
    Filed: May 4, 2006
    Publication date: March 26, 2009
    Applicant: Laboratoire Francais Du Fractionnement Et Des Biotechnologies
    Inventors: Jean-Thierry Aubin, Bruno You, Benoit Flan
  • Method for the in vitro titration of an ncta application thereof in a method for the evaluation and/or monitoring of a biological product production method
    Publication number: 20070072252
    Abstract: The invention relates to a method for the in vitro titration of a non-conventional transmissible agent (NCTA), using transgenic cell lines. The invention also relates to: the application of the aforementioned in vitro titration method in a method for the in vitro evaluation and/or monitoring of the effectiveness of a biological production or treatment method or of one or more steps in such a method for the elimination of an NCTA, and to the application thereof in a method for the in vitro evaluation and/or monitoring of a decontamination procedure.
    Type: Application
    Filed: August 23, 2004
    Publication date: March 29, 2007
    Applicant: Laboratoire Francais Du Fractionnement Et Des Biotechnologies
    Inventors: Jean-Thierry Aubin, Benoit Flan