Abstract: The specification relates to an apparatus for storage and dispensing of a topically applied medicament to an animal by a dosing regimen that helps to facilitate administration of uneven doses of a biologically active substance. The apparatus includes a blister pack 1, 4, 9 with a plurality of predetermined medicament-containing wells 2, 5, 10 where the wells 2, 5, 10 contain medicaments 3, 6, 11 incorporated within a solution suitable for topical administration and, wherein the medicament 3, 6, 11 contains at least one biologically-active compound. Indicia 13 are described to help facilitate administration including use of color indicia.

Abstract: The invention features a purified hyaluronidase BH55 polypeptide isolated from a mammalian species, preferably bovine or human. The invention also features DNA encoding BH55, vectors and transformed host cells containing DNA encoding BH55, methods of making BH55 hyaluronidase polypeptides, and antibodies that specifically bind BH55.

Abstract: The present invention provides polynucleic acid sequences that are functionally associated with autoimmune diseases, such as, for example, insulin-dependent diabetes mellitus. Significantly, quantities of transcriptional and translational product encoded by the invention polynucleic acid sequences are elevated in mammals having a predisposition to autoimmune disease, as compared to their quantities in normal mammals. In accordance with the present invention, there also are provided polypeptides encoded by the invention polynucleic acid sequences, antibodies that are capable of binding to the invention polypeptides, as well as methods and kits for screening for autoimmune diseases.

Abstract: The invention features a purified hyaluronidase BH55 polypeptide isolated from a mammalian species, preferably bovine or human. The invention also features DNA encoding BH55, vectors and transformed host cells containing DNA encoding BH55, the methods of making BH55 hyaluronidase polypeptides, and the antibodies that specifically bind BH55.

Abstract: An apparatus for measuring the concentration of selected solute in a solution. This apparatus is particulary suitable for measuring the concentration of blood components, such as blood late Maillard products. A beam of exposing light is imaged through a wall of a containment vessel onto a region of the sample adjacent to this wall to induce from said selected solute emission of light that includes at least one emission peak that can be used to calculate the concentration of this solute. At least one detector is positioned to maximize the strength of detected signal, if other components of this solution strongly absorb the emitted light. The exposing light is directed such that the detected signal is maximized as a function of the path of this exposing light. A particular embodiment is a low-cost, non-invasive blood Maillard products concentration detector. In this embodiment, the containment vessel is preferably one of the patient's fingers.

Abstract: An apparatus for measuring the concentration of a selected solute in a solution. This apparatus is particularly suitable for measuring the concentration of blood components, such as blood glucose. A beam of exposing light is imaged through a wall of a containment vessel onto a region of the sample adjacent to this wall to induce from said selected solute emission of light that includes at least one emission peak that can be used to calculate the concentration of this solute. At least one detector is positioned to maximize the strength of detected signal, if other components of this solution strongly absorb the emitted light. The exposing light is directed such that the detected signal is maximized as a function of the path of this exposing light. A particular embodiment is a non-invasive blood glucose tester that can be used painlessly by diabetics to monitor their blood glucose levels. In this embodiment, the containment vessel is preferably one of the patient's fingers.