Abstract: A medical delivery device comprising an elongate body having a plunger slidably and sealingly engaged to form a cavity to receive fluid materials and a first outlet disposed at an end of said body and has a male luer end portion and a valve assembly is disposed within the first outlet. The valve assembly has a valve means movable between an open position and a closed position and biasing means for biasing the valve means to a closed position. Actuating means are disposed within the male luer end portion and coupled to the valve means such that the valve means is movable to an open position when a female luer end portion of a medical accessory is coupled with the male luer end portion. A second outlet is disposed at the same end as the first outlet for controlling the exchange of gases from the environment to said cavity under the action of the plunger.