Abstract: The invention relates to a process for the preparation of a peracid, perester or diacylperoxide and is characterized in that a mixed anhydride of formula R1[C(O)OC(O)OR2]n or [R3C(O)OC(O)O]pR4 is contacted with a hydroperoxide of formula R5[OOH]m in the presence of a base, wherein R1 represents a mono-, di-, tri- or tetravalent C1-C19 hydrocarbon group, optionally containing one or more hetero atoms, n is 1-4, R2 represents a C1-C20 hydrocarbon group, optionally containing one or more hetero atoms, R3 represents a C1-C19 hydrocarbon group, optionally containing one or more hetero atoms, R4 represents a di-, tri- or tetravalent C1-C20 hydrocarbon group, optionally containing one or more hetero atoms, p is 2-4, R5 represents hydrogen or a mono- or divalent C3-C18 tertiary alkyl or C2-C20 acyl group, in which the tertiary alkyl or acyl group may optionally contain one or more hetero atoms, m is 1 or 2, and if R5 represents hydrogen, m is 1, provided that if the hydroperoxide is an &

Abstract: The invention relates to a process for the preparation of a peracid, perester or diacylperoxide and is characterized in that a mixed anhydride of formula R1[C(O)OC(O)OR2]n or [R3C(O)OC(O)O]pR4 is contacted with a hydroperoxide of formula R5[OOH]m in the presence of a base, wherein R1 represents a mono-, di-, tri- or tetravalent C1-C19 hydrocarbon group, optionally containing one or more hetero atoms, n is 1-4, R2 represents a C1-C20 hydrocarbon group, optionally containing one or more hetero atoms, R3 represents a C1-C19 hydrocarbon group, optionally containing one or more hetero atoms, R4 represents a di-, tri- or tetravalent C1-C20 hydrocarbon group, optionally containing one or more hetero atoms, p is 2-4, R5 represents hydrogen or a mono- or divalent C3-C18 tertiary alkyl or C2-C20 acyl group, in which the tertiary alkyl or acyl group may optionally contain one or more hetero atoms, m is 1 or 2, and if R5 represents hydrogen, m is 1, provided that if the hydroperoxide is an &

Abstract: The invention provides an implantable medical device system and method for determining when a patient is undergoing a sudden rate drop (SRD) that should be treated by intervention therapy. Two SRD detection algorithms are provided. A first algorithm is a rate-based algorithm that looks for rate drops that meet stored SRD criteria, and a second algorithm is a QT-based algorithm that detects when QT variations meet criteria that are associated with rate changes characteristic of onset of NMS. The system provides for a plurality of different intervention pacing therapies that are selected based on which detection algorithm, or both algorithms, indicate SRD. The priority of choice of algorithms is programmable.