Abstract: A sample bottle makes it possible to sample mixtures of water and gases in deep bore or drill holes. The filling of the volume (4) of the bottle is obtained by placing a volume (4) under a vacuum beforehand. Once in place, the pipe (10) is opened by withdrawing the piston (20) and opening the valve (6). Once the pressures balance, the valve (6) closes again and the piston (20) is reintroduced into the sleeve (8). Pressure compensation is provided by a sliding valve member (46). Emptying takes place by means of the tap (24), which is also initially used to place the volume (4) under a vacuum. The sample bottle is applicable to geothermy, nuclear power stations, oceanography and geochemistry.