Abstract: The present disclosure relates to the identification of a biomarker, consisting in a circulating miRNA, suitable for use in the diagnosis and prognosis of high-grade serous ovarian carcinoma (HGSOC), and to diagnostic kits for use in such diagnosis.

Abstract: The invention relates to a device (1) for producing radioisotopes by irradiating a target fluid using a particle beam (13). This device comprises an irradiation cell (7) that includes a cavity (3) for receiving the target fluid. A non-cryogenic cooling device cools the walls of the cavity (3). The cavity (3) has an inclined surface (15) downwardly delimiting the cavity (3) so as to evacuate the target fluid, which condenses on contact with the cooled walls, under gravity towards a metal foil (4) which closes off this cavity (3). The inclined surface (15) intersects the plane formed by the metal foil (4), making an acute angle (a) with said plane, so as to form with the metal foil (4) a wedge-shaped zone (18) capable of collecting, by gravity, the condensed target fluid.

Abstract: The present invention relates to an apparatus for producing a radioisotope by irradiating a target fluid comprising a precursor of said radioisotope with a particle beam produced by a particle accelerator, the apparatus comprising: —a housing comprising a target cavity for receiving said target fluid, said housing having an opening for allowing the passage of the said particle beam into the said cavity; —a dual foil flange for closing said opening of the target cavity, said dual foil flange comprising: —a standoff comprising a central hole; —a first and a second foil able to allow the passage of the said particle beam and located respectively on a first side and a second side of the said standoff, covering the said central hole and forming a cooling cavity; —a first flange and a second flange for sealing respectively the said first and second foil on said standoff; —at least an inlet channel and at least an outlet channel, for flowing a cooling fluid through the cavity of the dual foil flange; —guiding means

Abstract: The present invention relates to a disposable module (100) for use in a device (300) for synthesizing radiopharmaceutical products starting with chemical reagents, said disposable module (100) comprising: a supporting plate (101) comprising rigid connection means (114) to at least one flask of chemical reagents (102, 103, 104, 105) in solution in a solvent, and a reactor (106); interface means (115) with a fixed module of said synthesis device (300), in contact with or integrated into said supporting plate (101), said interface means comprising at least one valve (V1-V8) and/or at least one fluid inlet (E1, E2) and/or at least one fluid outlet (O1, O2, O3); at least one conduit (1-20) connected to said at least one valve (V1-V8) or to said at least one fluid inlet (E1, E2) or to said at least one fluid outlet (O1, O2, O3), characterized in that at least one of said conduits (1-20) is integrated into the body of the disposable module (100).

Abstract: The invention relates to a device (1) for producing radioisotopes by irradiating a target fluid using a particle beam (13). This device comprises an irradiation cell (7) that includes a cavity (3) for receiving the target fluid. A non-cryogenic cooling device cools the walls of the cavity (3). The cavity (3) has an inclined surface (15) downwardly delimiting the cavity (3) so as to evacuate the target fluid, which condenses on contact with the cooled walls, under gravity towards a metal foil (4) which closes off this cavity (3). The inclined surface (15) intersects the plane formed by the metal foil (4), making an acute angle (a) with said plane, so as to form with the metal foil (4) a wedge-shaped zone (18) capable of collecting, by gravity, the condensed target fluid.

Abstract: The present invention relates to an apparatus for producing a radioisotope by irradiating a target fluid comprising a precursor of said radioisotope with a particle beam produced by a particle accelerator, the apparatus comprising:—a housing comprising a target cavity for receiving said target fluid, said housing having an opening for allowing the passage of the said particle beam into the said cavity;—a dual foil flange for closing said opening of the target cavity, said dual foil flange comprising:—a standoff comprising a central hole;—a first and a second foil able to allow the passage of the said particle beam and located respectively on a first side and a second side of the said standoff, covering the said central hole and forming a cooling cavity;—a first flange and a second flange for sealing respectively the said first and second foil on said standoff;—at least an inlet channel and at least an outlet channel, for flowing a cooling fluid through the cavity of the dual foil flange;—guiding means for pos

Abstract: The invention relates to a static seal of the type that comprises a support (3). According to the invention, a layer of elastomer is cold-deposited on at least one face of the support and subsequently shaped, with the optional formation of threads or ribs (7), in a heated mould which is also used for curing. The support is characterised in that not all of the surface thereof is covered with the elastomer and the non-covered zones perform a function other than sealing.

Abstract: Pesticidal compositions comprising a pesticidally effective amount of at least one pyrethrinoid, a biphenyl aromatic solvent and optionally a mineral, vegetable or transesterified vegetable oil and a method of combatting pests.

Abstract: A lifting device designed to be mounted on the chassis of a vehicle for loading and unloading the vehicle having a first arm designed to be articulated at least indirectly to the chassis of the vehicle and, attached to the first arm, a second arm normally perpendicular to the first arm ending with a hook for grasping an upper part of the load. The second arm is retractable and is formed by a first section attached to the first arm and a second section carrying the hook, movable relative to the first section between a retracted configuration and a working configuration, at least one pair of complementary locking members being provided for locking the second section in its working configuration.

Abstract: Rod shaped monocrystals are formed by causing monocrystalline deposition to take place in that body from a melt formed by heating a longitudinal section of that body with individual trough shaped heating elements.