Patents by Inventor Bernat Isern Amengual
Bernat Isern Amengual has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240066042Abstract: Use of a derivative containing C—O—P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimimetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.Type: ApplicationFiled: July 21, 2023Publication date: February 29, 2024Inventors: Joan PERELLO BESTARD, Carolina SALCEDO ROCA, Miguel David FERRER REYNES, Bernat ISERN AMENGUAL, Pieter H. JOUBERT
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Publication number: 20230340003Abstract: The present invention provides processes for preparing soluble salts of inositol phosphate characterized by a low level of impurities. Processes for preparing soluble salts (e.g., alkali-metal or ammonium) of inositol phosphates (e.g., hexasodium or dode-casodium salts), and of inositol hexaphosphate in particular (e.g., Na6IP6 and Na12IP6), are described. Also provided are pharmaceutical compositions, methods of use, combination treatments, kits, and articles of manufacture comprising soluble salts of inositol phosphates prepared according to the method of the invention.Type: ApplicationFiled: May 19, 2023Publication date: October 26, 2023Inventors: Bernat ISERN AMENGUAL, Marco Antonio MORENO SATURINO, Joan PERELLÓ BESTARD
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Publication number: 20220249521Abstract: Use of a derivative containing C—O—P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimimetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.Type: ApplicationFiled: April 25, 2022Publication date: August 11, 2022Applicant: Sanifit Therapeutics S.A.Inventors: Joan PERELLO BESTARD, Carolina SALCEDO ROCA, Miguel David FERRER REYNES, Bernat ISERN AMENGUAL, Pieter H. JOUBERT
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Publication number: 20220187326Abstract: The present invention relates to method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200, wherein the compound to be detected and/or quantified is a chemically complex molecule, wherein said chemically complex molecule is substituted with at least two groups R, wherein each R group means independently —OH, —OP(O)(OH)2 or —P(O)(OH)2, with the proviso that at least two R are independently selected from —P(O)(OH)2 and —OP(O)(OH)2, wherein the compound or compounds to be detected and/or quantified are within a biological matrix, wherein said biological matrix is a biological fluid, a biological tissue, stomach contents, intestine contents, stool sample or a culture cells, wherein the method comprises performing a chromatography and identifying the retention time and/or the intensity of the signal by means of a mass or radioactivity detector.Type: ApplicationFiled: October 28, 2021Publication date: June 16, 2022Inventors: Joan PERELLO BESTARD, Ciriaco MARASCHIELLO DE ZUANI, Irene LENTHERIC, Paula MENDOZA DE LAS HERAS, Fernando TUR ESPINOSA, Eva TUR TUR, Maximo ENCABO ALARCON, Eva MARTIN BECERRA, Maria de Mar BENITO AMENGUAL, Bernat ISERN AMENGUAL
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Patent number: 11162958Abstract: The present invention relates to method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200, wherein the compound to be detected and/or quantified is a chemically complex molecule, wherein said chemically complex molecule is substituted with at least two groups R, wherein each R group means independently —OH, —OP(O)(OH)2 or —P(O)(OH)2, with the proviso that at least two R are independently selected from —P(O)(OH)2 and —OP(O)(OH)2, wherein the compound or compounds to be detected and/or quantified are within a biological matrix, wherein said biological matrix is a biological fluid, a biological tissue, stomach contents, intestine contents, stool sample or a culture cells, wherein the method comprises performing a chromatography and identifying the retention time and/or the intensity of the signal by means of a mass or radioactivity detector.Type: GrantFiled: February 17, 2017Date of Patent: November 2, 2021Assignee: Sanifit Therapeutics S.A.Inventors: Joan Perello Bestard, Ciriaco Maraschiello De Zuani, Irene Lentheric, Paula Mendoza De Las Heras, Fernando Tur Espinosa, Eva Tur Tur, Maximo Encabo Alarcon, Eva Martin Becerra, Maria de Mar Benito Amengual, Bernat Isern Amengual
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Publication number: 20190167702Abstract: Use of a derivative containing C—O—P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimimetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.Type: ApplicationFiled: December 4, 2018Publication date: June 6, 2019Applicant: LABORATORIS SANIFIT, S.L.Inventors: Joan PERELLO BESTARD, Carolina SALCEDO ROCA, Miguel David FERRER REYNES, Bernat ISERN AMENGUAL, Pieter H. JOUBERT
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Patent number: 10010559Abstract: Use of a derivative containing C—O—P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimimetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.Type: GrantFiled: May 24, 2016Date of Patent: July 3, 2018Assignee: LABORATORIOS SANIFIT, S.L.Inventors: Joan Perello Bestard, Carolina Salcedo Roca, Miguel David Ferrer Reynes, Bernat Isern Amengual, Pieter H. Joubert
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Publication number: 20170360810Abstract: Use of a derivative attaining C-O-P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimimetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.Type: ApplicationFiled: June 1, 2017Publication date: December 21, 2017Inventors: Joan PERELLO BESTARD, Carolina SALCEDO ROCA, Miguel David FERRER REYNES, Bernat ISERN AMENGUAL, Pieter H. JOUBERT
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Publication number: 20170254823Abstract: The present invention relates to method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200, wherein the compound to be detected and/or quantified is a chemically complex molecule, wherein said chemically complex molecule is substituted with at least two groups R, wherein each R group means independently —OH, —OP(O)(OH)2 or —P(O)(OH)2, with the proviso that at least two R are independently selected from —P(O)(OH)2 and —OP(O)(OH)2, wherein the compound or compounds to be detected and/or quantified are within a biological matrix, wherein said biological matrix is a biological fluid, a biological tissue, stomach contents, intestine contents, stool sample or a culture cells, wherein the method comprises performing a chromatography and identifying the retention time and/or the intensity of the signal by means of a mass or radioactivity detector.Type: ApplicationFiled: February 17, 2017Publication date: September 7, 2017Inventors: Joan PERELLO BESTARD, Ciriaco MARASCHIELLO DE ZUANI, Irene LENTHERIC, Paula MENDOZA DE LAS HERAS, Fernando TUR ESPINOSA, Eva TUR TUR, Maximo ENCABO ALARCON, Eva MARTIN BECERRA, Maria de Mar BENITO AMENGUAL, Bernat ISERN AMENGUAL
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Patent number: 9612250Abstract: The present invention relates to method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200, wherein the compound to be detected and/or quantified is a chemically complex molecule, wherein said chemically complex molecule is substituted with at least two groups —R, wherein each R group means independently —OH, —OP(O)(OH)2 or —P(O)(OH)2, with the proviso that at least two R are independently selected from —P(O)(OH)2 and —OP(O)(OH)2, wherein the compound or compounds to be detected and/or quantified are within a biological matrix, wherein said biological matrix is a biological fluid, a biological tissue, stomach contents, intestine contents, stool sample or a culture cells, wherein the method comprises performing a chromatography and identifying the retention time and/or the intensity of the signal by means of a mass or radioactivity detector.Type: GrantFiled: October 8, 2012Date of Patent: April 4, 2017Assignee: Laboratorios Sanifit, S.L.Inventors: Joan Perello Bestard, Ciriaco Maraschiello de Zuani, Irene Lentheric, Paula Mendoza de las Heras, Fernando Tur Espinosa, Eva Tur Tur, Maximo Encabo Alarcon, Eva Martin Becerra, Maria de Mar Benito Amengual, Bernat Isern Amengual
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Publication number: 20170020903Abstract: Use of a derivative containing C-O-P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimimetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.Type: ApplicationFiled: May 24, 2016Publication date: January 26, 2017Inventors: Joan PERELLO BESTARD, Carolina SALCEDO ROCA, Miguel David FERRER REYNES, Bernat ISERN AMENGUAL, Pieter H. JOUBERT
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Patent number: 9433710Abstract: The present invention relates to a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein a compound selected from the group consisting of an IP, an ester of an IP, and/or a pharmaceutically acceptable salt thereof, or a combination thereof, is/are covalently bound to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. The covalent bond between the IP and the metal, metal alloy or metal oxide surface can be further assisted by the use of a linker. An implant according to the invention provides for a modulated and/or improved osseointegrative effect when implanted into a body, such as a mammalian body, by virtue of the coating comprising covalently bound phytate.Type: GrantFiled: December 26, 2012Date of Patent: September 6, 2016Assignees: LABORATORIES SANIFIT, S. L., NUMAT BIOMEDICAL, S. L.Inventors: Marta Monjo Cabrer, Joan Perelló Bestard, Joana María Ramis Morey, Fernando Tur Espinosa, María del Mar Arriero Sánchez, Eva Martín Becerra, Bernat Isern Amengual, Rubén Henríquez Paláez
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Patent number: 9364490Abstract: Use of a derivative containing C—O—P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimirnetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.Type: GrantFiled: March 14, 2014Date of Patent: June 14, 2016Assignee: LABORATORIS SANIFIT, S.L.Inventors: Joan Perello Bestard, Carolina Salcedo Roca, Miguel David Ferrer Reynes, Bernat Isern Amengual, Pieter H. Joubert
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Publication number: 20160061813Abstract: Portable device (1) for analysing pH or another variable by electrochemical measurement comprising a sensor (2), a microprocessor (3) and display means (4) for the results of the analysis. The portable device makes it possible to carry out pre-diagnoses quickly and easily without the need for specialist staff.Type: ApplicationFiled: September 2, 2015Publication date: March 3, 2016Inventors: Isabel GOMILA MUÑOZ, Feliciano Grases Freixedas, Antonia Costa-Bauza, Rafael M. Prieto Almirall, Eva Martin Becerra, Ruben Henriquez Pelaez, Bernat Isern Amengual, Joan Perello Bestard
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Patent number: 9144578Abstract: The invention relates to a fixed-dose association of phytate and zinc in synergic proportions for use in the treatment of crystallization of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallization of hydroxyapatite in humans.Type: GrantFiled: February 19, 2013Date of Patent: September 29, 2015Assignee: Universitat de les Illes BalearsInventors: Felix Grases Freixedas, Joan Perello Bestard, Bernat Isern Amengual, Pilar Sanchis Cortes, Rafael M. Prieto Almirall, Antonia Costa Bauza
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Publication number: 20150212101Abstract: The present invention relates to method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200, wherein the compound to be detected and/or quantified is a chemically complex molecule, wherein said chemically complex molecule is substituted with at least two groups —R, wherein each R group means independently —OH, —OP(O)(OH)2 or —P(O)(OH)2, with the proviso that at least two R are independently selected from —P(O)(OH)2 and —OP(O)(OH)2, wherein the compound or compounds to be detected and/or quantified are within a biological matrix, wherein said biological matrix is a biological fluid, a biological tissue, stomach contents, intestine contents, stool sample or a culture cells, wherein the method comprises performing a chromatography and identifying the retention time and/or the intensity of the signal by means of a mass or radioactivity detector.Type: ApplicationFiled: October 8, 2012Publication date: July 30, 2015Applicant: Laboratorios Sanifit, S.L.Inventors: Joan Perello Berstard, Ciriaco Maraschiello de Zuani, Irene Lentheric, Paula Mendoza de las Heras, Fernando Tur Espinosa, Eva Tur Tur, Maximo Encabo Alarcon, Eva Martin Becerra, Maria de Mar Benito Amengual, Bernat Isern Amengual
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Publication number: 20150004208Abstract: The present invention relates to a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein a compound selected from the group consisting of an IP, an ester of an IP, and/or a pharmaceutically acceptable salt thereof, or a combination thereof, is/are covalently bound to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. The covalent bond between the IP and the metal, metal alloy or metal oxide surface can be further assisted by the use of a linker. An implant according to the invention provides for a modulated and/or improved osseointegrative effect when implanted into a body, such as a mammalian body, by virtue of the coating comprising covalently bound phytate.Type: ApplicationFiled: December 26, 2012Publication date: January 1, 2015Inventors: Marta Monjo Cabrer, Joan Perelló Bestard, Joana María Ramis Morey, Fernado Tur Espinosa, María del Mar Arriero Sánchez, Eva Martín Becerra, Bernat Isern Amengual, Rubén Henríquez Paláez
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Publication number: 20140271915Abstract: Use of a derivative containing C—O—P bonds in a controlled release form to treat patients with kidney failure. Moreover, it comprises the use of said derivatives together with other active substances, which particularly may be selected from a list comprising a calcimirnetic, vitamin, phosphate binder, thiosulfate, bisphosphonate, pyrophosphate, citrate, diuretic, antihypertensive and anticholesteraemic agent.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: LABORATORIS SANIFIT, S.L.Inventors: Joan PERELLO BESTARD, Carolina SALCEDO ROCA, Miguel David FERRER REYNES, Bernat ISERN AMENGUAL, Pieter H. JOUBERT
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Patent number: 8377909Abstract: The present invention relates to the use of myo-inositol hexaphosphate or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention or treatment of a disease associated with the dissolution of crystals of calcium salts, in particular osteoporosis. These compounds may be utilized in the manufacture of functional foods, dietetic supplements, vitamin supplements, nutritional supplements, food supplements, or phytotherapeutic products having properties of inhibition of dissolution of crystals of calcium salts.Type: GrantFiled: May 30, 2007Date of Patent: February 19, 2013Assignee: Universitat de les Illes BalearsInventors: Felix Grases Freixedas, Pilar Sanchis Cortes, Antonia Costa-Bauza, Joan Perello Bestard, Rafael Mara Prieto Almirall, Bernat Isern Amengual, Ramon Garcia Gonzalez
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Patent number: 8377908Abstract: The invention relates to a fixed-dose association of 5 phytate and zinc in synergic proportions for use in the treatment of crystallization of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said 10 association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallization of hydroxyapatite in humans.Type: GrantFiled: February 14, 2007Date of Patent: February 19, 2013Inventors: Felix Grases Freixedas, Joan Perello Bestard, Bernat Isern Amengual, Pilar Sanchis Cortes, Rafael M Prieto Almirall, Antonia Costa Bauza