Patents by Inventor Bernd Betzler

Bernd Betzler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for selective oligonucleotide modification
    Patent number: 8936910
    Abstract: Method for producing a modified oligonucleotide, wherein at least one polymer, preferably polyalkylene oxide, and/or a compound is covalently bound to the 5?-end or the 3?-end of the oligonucleotide via native ligation forming a native ligation site, with the proviso that the polymer and/or the compound is not a protein or peptide, if only the 5?-end of the oligonucleotide is modified by binding of the polymer or compound via native ligation. The invention is further directed to a modified oligonucleotide obtainable by the inventive method as well as the use of such modified oligonucleotide for the preparation of a medicament for preventing and/or treating a tumor, formation of metastasis, an immune disease or disorder, a cardiovascular disease or disorder, and/or a viral disease or disorder.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: January 20, 2015
    Assignee: Antisense Pharma GmbH
    Inventors: Andreas Mitsch, Karl-Hermann Schlingensiepen, Bernd Betzler, Frank Jaschinski, Anneliese Schneider
  • METHOD FOR SELECTIVE OLIGONUCLEOTIDE MODIFICATION
    Publication number: 20130172238
    Abstract: Method for producing a modified oligonucleotide, wherein at least one polymer, preferably polyalkylene oxide, and/or a compound is covalently bound to the 5?-end or the 3?-end of the oligonucleotide via native ligation forming a native ligation site, with the proviso that the polymer and/or the compound is not a protein or peptide, if only the 5?-end of the oligonucleotide is modified by binding of the polymer or compound via native ligation. The invention is further directed to a modified oligonucleotide obtainable by the inventive method as well as the use of such modified oligonucleotide for the preparation of a medicament for preventing and/or treating a tumor, formation of metastasis, an immune disease or disorder, a cardiovascular disease or disorder, and/or a viral disease or disorder.
    Type: Application
    Filed: June 10, 2011
    Publication date: July 4, 2013
    Inventors: Andreas Mitsch, Karl-Hermann Schlingensiepen, Bernd Betzler, Frank Jaschinski, Anneliese Schneider