Abstract: The disclosure provides compositions comprising novel adenosine base editors (e.g., ABE8) that have increased efficiency and methods of using these adenosine deaminase variants for editing a target sequence.

Abstract: A gaseous fluid filter has a filter element insertable into the filter housing through a service opening. A clamping wedge is insertable in a joining direction for clamping the filter element in clamping direction against the filter housing. The filter element rests against the filter housing with a seal surface facing away from the clamping wedge. The clamping wedge has a housing wedge side facing a housing stop and a filter element wedge side facing a filter element stop. These wedge sides each have first and second bearing surfaces separated by a step. The joining direction extends in or parallel to a contact plane between housing wedge side and housing stop. The first and/or second bearing surface of the filter element wedge side is positioned at a wedge base angle of 1° to 20° to the joining direction. The steps of the wedge sides are offset in joining direction.

Abstract: A filter has a filter housing with a housing cover coupled to a housing part to close a receiving space receiving filter elements each provided with a filter medium body and a frame device around the filter medium body. The filter housing has a radially inwardly projecting, circumferential contact shoulder in the receiving space. The housing cover, when mounted, exerts an axial clamping force on the frame device of a first filter element. An axial end of the first filter element facing away from the housing cover rests on the frame device of a second filter element. The clamping force is transmitted through frame device of first filter element to frame device of second filter element. The frame device of the second filter element has a circumferential seal with a hollow chamber profile pressed by the clamping force on the contact shoulder to seal-tightly contact the contact shoulder.

Abstract: An adsorber element for a filter system is provided with a frame that has a base plate and one or more rigid support elements that project away from the base plate. An adsorber medium is disposed at the frame and arranged at least in sections of the base plate and at least in sections of the one or more rigid support elements. The filter system has a housing with an inlet and an outlet. The filter system is flowed through by a gaseous fluid from the inlet to the outlet. A filter element is arranged in the housing between inlet and outlet. The adsorber element is arranged in the housing preferably downstream of the filter element.

Abstract: A filter element for filtering a fluid is provided with at least one filter bellows with a first areal inflow surface for a first fluid flow of the fluid and at least one second inflow surface for a second fluid flow of the fluid separate from the first fluid flow of the fluid. The at least one second inflow surface is separate from the first areal inflow surface. A flow channel section for the second fluid flow of the fluid is provided. At least one compensation element is arranged in the flow channel section for the second fluid flow of the fluid at a raw side of the filter element. A filter system with a filter housing is provided with such a filter element arranged exchangeably in the filter housing.

Abstract: A filter element for filtering a fluid has a frame and at least one filter bellows arranged in the frame and provided with a first areal inflow surface for a first fluid flow and at least one second inflow surface for a second fluid flow separate from the first fluid flow. The second inflow surface is separate from the first areal inflow surface. A flow channel is provided to guide the second fluid flow and has a raw-side flow channel section arranged within the frame. A filter system provided with a filter housing is provided with such a filter element arranged exchangeably in the filter housing between a raw side and a clean side. The filter housing has a first inlet for the first fluid flow communicating with the first inflow surface and at least a second inlet for the second fluid flow communicating with the second inflow surface.

Abstract: A fastening module for connecting a filter system to an arched connecting surface with openings for a fluid has a connecting housing connectable in fluid communication to the filter system. Rigid individual channel pieces are arranged in the connecting housing and channels extend in the channel pieces. The channels correspond with the openings in the arched connecting surface. The channel pieces have connecting flanges to be connected to the openings in the arched connecting surface. The channel pieces are connected by flexible connecting regions with each other; with the connecting housing; or with each other and with the connecting housing. The fastening module is connected in fluid communication to the inlet region or outlet region of the filter system. A filter module for the filter system has substantially free intake across its cross section and enables an intake manifold-type distribution of a volume flow passing through the filter element.

Abstract: A method for producing a filter element provided with a sealing part in which the sealing material is introduced into a casting chamber between two tundish parts when in the non-cured state, and a compensation space connected to the casting chamber for the expansion of the sealing material.

Abstract: A method for producing a filter element provided with a sealing part in which the sealing material is introduced into a casting chamber between two tundish parts when in the non-cured state, and a compensation space connected to the casting chamber for the expansion of the sealing material.

Abstract: An adsorber element for a filter system is provided with a frame that has a base plate and one or more rigid support elements that project away from the base plate. An adsorber medium is disposed at the frame and arranged at least in sections of the base plate and at least in sections of the one or more rigid support elements. The filter system has a housing with an inlet and an outlet. The filter system is flowed through by a gaseous fluid from the inlet to the outlet. A filter element is arranged in the housing between inlet and outlet. The adsorber element is arranged in the housing preferably downstream of the filter element.

Abstract: A method for producing a filter element provided with a sealing part in which the sealing material is introduced into a casting chamber between two tundish parts when in the non-cured state, and a compensation space connected to the casting chamber for the expansion of the sealing material.

Abstract: A fastening module for connecting a filter system to an arched connecting surface with openings for a fluid has a connecting housing connectable in fluid communication to the filter system. Rigid individual channel pieces are arranged in the connecting housing and channels extend in the channel pieces. The channels correspond with the openings in the arched connecting surface. The channel pieces have connecting flanges to be connected to the openings in the arched connecting surface. The channel pieces are connected by flexible connecting regions with each other; with the connecting housing; or with each other and with the connecting housing. The fastening module is connected in fluid communication to the inlet region or outlet region of the filter system. A filter module for the filter system has substantially free intake across its cross section and enables an intake manifold-type distribution of a volume flow passing through the filter element.

Abstract: A filter element has a filter bellows with circumferential seal having a seal region and a fastening region with radial and axial fastening sections. The radial fastening section has a holding surface facing away from the filter bellows and engaging a radially inner pressure-exerting section of a housing. The axial fastening section provides a radially inner boundary of a circumferential groove of the seal region that receives a radially outer pressure-exerting section of the housing. A seal projection forms a radially outer boundary of the groove. The seal region has an axially acting sealing surface opposite the groove axially spaced farther from an axial filter bellows end face than the holding surface. Axial spacing between groove base and axially acting sealing surface is greater than a spacing between a transition of the groove base into the axial fastening section and a transition of the holding surface into the seal region.

Abstract: A method for producing a filter element provided with a sealing part in which the sealing material is introduced into a casting chamber between two tundish parts when in the non-cured state, and a compensation space connected to the casting chamber for the expansion of the sealing material.

Abstract: A method for producing a filter element provided with a sealing part in which the sealing material is introduced into a casting chamber between two tundish parts when in the non-cured state, and a compensation space connected to the casting chamber for the expansion of the sealing material.

Abstract: A filter element has a filter bellows with circumferential seal having a seal region and a fastening region with radial and axial fastening sections. The radial fastening section has a holding surface facing away from the filter bellows and engaging a radially inner pressure-exerting section of a housing. The axial fastening section provides a radially inner boundary of a circumferential groove of the seal region that receives a radially outer pressure-exerting section of the housing. A seal projection forms a radially outer boundary of the groove. The seal region has an axially acting sealing surface opposite the groove axially spaced farther from an axial filter bellows end face than the holding surface. Axial spacing between groove base and axially acting sealing surface is greater than a spacing between a transition of the groove base into the axial fastening section and a transition of the holding surface into the seal region.

Abstract: A filter device is provided with a filter housing and a housing cover closing off the filter housing. A filter element is disposed in the filter housing. The filter element comprises a first form-fit part projecting past an outer wall surface of the filter element. The housing cover is provided with a second form-fit part correlated with the first form-fit part. The first and second form-fit parts engage each other in a mounted state of the filter element on the housing cover. The first form-fit part is a laterally projecting hook.

Abstract: A method for producing a filter element provided with a sealing part in which the sealing material is introduced into a casting chamber between two tundish parts when in the non-cured state, and a compensation space connected to the casting chamber for the expansion of the sealing material.

Abstract: A filter device is provided with a filter housing and a housing cover closing off the filter housing. A filter element is disposed in the filter housing. The filter element has a clamping element that is resting with a clamping force on a first housing part that is provided on the filter housing or on the housing cover. The filter element further has a lever element that, in the mounted state of the filter element in the filter housing, is resting on a second housing part that is provided on the filter housing or on the housing cover and force-loads the clamping element against the first housing part. The clamping element and the lever element form a single part and are preferably provided on an end disk of the filter element.

Abstract: For a method for producing a filter element provided with a sealing part, wherein the sealing material is introduced into a casting chamber between two tundish parts when in the non-cured state, a compensation space connected to the casting chamber is provided for the expansion of the sealing material.