Abstract: The present disclosure concerns an in-vitro method for the identification and analysis of proteins with a stem cell function, in which initially, at least one three-dimensional sweat gland equivalent with from about 500 to about 500000 sweat gland cells as well as a diameter of from about 100 to about 6000 ?m is provided and subsequently, proteins with a stem cell function in this equivalent are identified and analyzed. Preferably, in a further step c) of the method, the influence of test substances on the proteins previously identified in step b) is investigated. Because the three-dimensional sweat gland equivalents used in step a) comprise differently differentiated cells and emulate the in-vivo situation well, the measured data obtained with the in-vitro method as contemplated herein can readily be applied to the in-vivo situation.

Abstract: The present disclosure relates to an in-vitro method for identifying and analyzing ion channels and/or water channels and/or receptors of signal transduction, in which a three-dimensional sweat gland equivalent having from about 500 to about 500,000 sweat gland cells and a diameter of from about 100 to about 6,000 ?m is firstly provided and then any ion channels and/or water channels and/or receptors of signal transduction present in this equivalent are infected and analysed. In a further method step c) the influence of test substances on the proteins identified previously in step b) is examined. Since the three-dimensional sweat gland equivalents used in step a) comprise differently differentiated cells and portray the in-vivo situation well, the measurement data obtained with the in-vitro method as contemplated herein can be transferred well to the in-vivo situation.

Abstract: The present disclosure relates to an in-vitro method for identifying and analyzing secretion proteins, in which a three-dimensional sweat gland equivalent having from about 500 to about 500,000 sweat gland cells and a diameter of from about 100 to about 6,000 ?m is firstly provided and then any secretion proteins present in this equivalent are infected and analyzed. In a further method step c) the influence of test substances on the proteins identified previously in step b) is examined. Since the three-dimensional sweat gland equivalents used in step a) comprise differently differentiated cells and portray the in-vivo situation well, the measurement data obtained with the in-vitro method as contemplated herein can be transferred well to the in-vivo situation.

Abstract: The present disclosure concerns an in-vitro full skin model which comprises a dermal equivalent and epidermal equivalent as well as from about 1 to about 100 three-dimensional sweat gland equivalents with respectively from about 500 to about 500000 sweat gland cells as well as a diameter of respectively from about 100 to about 6000 ?m on a supporting layer. Furthermore, the present disclosure concerns the production of the full skin model as well as the use of this model as an in-vitro model, in screening methods as well as for in-vitro evaluation of the influence of cosmetic substances on the inhibition of sweat secretion as well as body odor.

Abstract: The present disclosure relates to a method for reduction of perspiration of the body and/or reduction of the body odor released by the perspiration in which antiperspirant cosmetic agents containing phosphate (M1) are applied to the human skin and remain on the application point for at least about 1 hour. Use of at least one phosphate compound in this method has an antiperspirant effect or a reduction of the body odor released by sweat.

Abstract: The present invention relates to an antiperspirant cosmetic agent including at least one specific protein from legumes of the genus Pisum and/or Phaseolus and/or Vigna and/or Macrotyloma or from cruciferous plants of the genus Brassica and including no aluminum and/or zirconium halides and/or hydroxyhalides. The present invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) are effectively influenced, thus resulting in a significant reduction in axillary sweat even in the absence of antiperspirant aluminum salts.

Abstract: The present disclosure relates to a method for reduction of perspiration of the body and/or reduction of the body odor released by the perspiration in which antiperspirant cosmetic agents containing phosphate (M1) are applied to the human skin and remain on the application point for at least 1 hour. Use of at least one phosphate compound in combination with the antiperspirant aluminum- and/or aluminum zirconium salts in this method has an antiperspirant effect or a reduction of the body odor released by sweat.

Abstract: The present disclosure relates to anhydrous cosmetic compositions which contain a combination of a strongly swelling and a low-swelling water-absorbing component in combination with a deodorant active ingredient. These compositions have an outstanding deodorizing effect and improved sensory features and additionally result in a minimization of sweat spots on textiles. Furthermore, the present disclosure relates to a cosmetic product containing these anhydrous compositions and the use of the composition or product for reduction of the body odor released by perspiration. Finally, the present disclosure relates to the use a strongly swelling water-absorbing component to improve the sensory characteristics of anhydrous deodorant compositions.

Abstract: The present disclosure relates to anhydrous cosmetic compositions which contain a combination of a strongly swelling and a low-swelling water-absorbing component, an odor-absorbing component and a deodorant active ingredient. These compositions have an outstanding deodorizing effect and improved sensory features and additionally result in a minimization of sweat spots on textiles. Furthermore, the present disclosure relates to a cosmetic product containing these anhydrous compositions and the use of this composition or product for reduction of the body odor released by perspiration. Finally, the present disclosure relates to the use a strongly swelling water-absorbing component in combination with an odor-absorbing component to improve the sensory characteristics of anhydrous deodorant compositions.

Abstract: The present disclosure relates to a method for improving the culture conditions of cultures of primary sweat gland cells and/or three-dimensional sweat gland equivalents, where the culture with from about 500 to about 500,000 sweat gland cells and a diameter of from about 100 to about 6,000 nm is initially prepared and then cultivated in a culture medium with neurotransmitters and/or from about 11 to about 100 ng/ml of at least one growth factor. Cultivation of these cells and models in a culture medium containing at least one neurotransmitter and/or from about 11 to about 100 ng/ml of at least one growth factor leads to an increase of sweat-gland-specific marker proteins. As a result, a loss of function, which occurs with an absence of or only low expression of these markers, can be avoided.

Abstract: The invention relates to an antiperspirant cosmetic agent, including a) at least one substance, selected form the group of cosmetic oils that are liquid at 20° C. and 1.013 hPa, aromatic substances, and waxes, b) at least one antiperspirant aluminum salt in a total amount of 0.

Abstract: The invention relates to an antiperspirant cosmetic agent which includes at least one specific chitosan and which is free of aluminum-containing compounds, in particular free of halides and/or hydroxy halides of aluminum and/or zirconium. The present invention further relates to the use of a specific chitosan and to a non-therapeutic method for reducing body perspiration. Adding or using the at least one specific chitosan ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in underarm perspiration even in the absence of antiperspirant aluminum-containing compounds.

Abstract: The present invention relates to propellant-containing deodorant and/or antiperspirant compositions that include specific preservative-agent combinations. The present invention also relates to a method for preventing and/or reducing the perspiration of the body and/or for preventing and/or reducing body odor by using the cosmetic agents according to the invention and the use of a certain preservative-agent combination to preserve propellant-containing deodorant and/or antiperspirant compositions.

Abstract: The present invention relates to propellant-free deodorant and/or antiperspirant compositions comprising at least two different preservatives. The present invention furthermore relates to a method for preventing and/or reducing perspiration of the body and/or for preventing and/or reducing body odor, using the cosmetic agent according to the invention.

Abstract: The present invention relates to propellant-containing deodorant and/or antiperspirant compositions comprising at least two different preservatives. The present invention furthermore relates to a method for preventing and/or reducing perspiration of the body and/or for preventing and/or reducing body odor, using the cosmetic agent according to the invention.

Abstract: The present invention relates to propellant-free deodorant and/or antiperspirant compositions that include specific preservative-agent combinations. The present invention also relates to a method for preventing and/or reducing the perspiration of the body and/or for preventing and/or reducing body odor by using the cosmetic agents according to the invention and the use of a certain preservative-agent combination to preserve propellant-free deodorant and/or antiperspirant compositions.

Abstract: The invention relates to an antiperspirant cosmetic including at least one specific design protein and which is exempt of aluminum and/or zirconium halides and/or hydroxy halides. The invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in axillary hyperhidrosis even in the absence of antiperspirant aluminum salts.

Abstract: The present invention relates to an antiperspirant cosmetic agent that includes at least one specific protein from Malvaceae of the genus Adansonia and is free of aluminum and/or zirconium halides and/or hydroxy halides. The present invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in underarm sweat even in the absence of antiperspirant aluminum salts.

Abstract: A cosmetic method for reducing perspiration of the body and/or for reducing body odor triggered by perspiration is provided herein. In one embodiment, the method includes the step of applying an antiperspirant cosmetic agent (M1) to human skin. The method further includes the step of maintaining the antiperspirant cosmetic agent (M1) on the application site for at least an hour. A packaging unit is also provided herein. In another embodiment, the packaging unit includes, formulated separately from one another, a) at least one first container (C1), containing a cosmetic agent (M1), and b) at least one second container (C2), containing a cosmetic agent (M2).

Abstract: The invention relates to an antiperspirant cosmetic including at least one specific protein from human or animal sources or from fish or birds or eggs and which is exempt of aluminum and/or zirconium halides and/or hydroxy halides and Bovine serum albumin (BSA). The invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in axillary hyperhidrosis even in the absence of antiperspirant aluminum salts.