Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: An analysis system and a method for testing a biological sample according to which, before the start of testing, the amount of energy remaining in an energy storage of the analysis device is compared with an energy requirement for the test, and the test is only started if the amount of energy meets the energy requirement, and/or a temperature-control apparatus designed for temperature-controlling the cartridge is controlled depending on an interior space temperature of the analysis device.

Abstract: An analysis system and a method for testing a biological sample according to which, before the start of testing, the amount of energy remaining in an energy storage of the analysis device is compared with an energy requirement for the test, and the test is only started if the amount of energy meets the energy requirement, and/or a temperature-control apparatus designed for temperature-controlling the cartridge is controlled depending on an interior space temperature of the analysis device.

Abstract: An analyzer for testing a biological sample is proposed, wherein the analyzer comprises a pressurized gas supply having an intermediate gas storage that is fluidically arranged between an intermediate valve and an actuation valve. A method for testing a biological sample is proposed, wherein the power supply of an intermediate valve is cut off when the valve starts to change its position and/or wherein the pressure of an intermediate gas storage located downstream of an intermediate valve is controlled. Further, a method for inspecting an analyzer, in particular its pressurized gas supply, is proposed, wherein the pressure drop in a main gas storage is measured and compared to a reference pressure drop in order to inspect the analyzer.

Abstract: An analysis system and a method for testing a biological sample is proposed, wherein, before the start of the test, the amount of energy remaining in an energy storage means of the analysis device is compared with an energy requirement for the test, and the test is only started if the amount of energy meets the energy requirement, and/or a temperature-control apparatus designed for temperature-controlling the cartridge is controlled depending on an interior space temperature of the analysis device.

Abstract: A hitch to be used with a one-wheeled trailer to be towed by a bicycle, motorcycle, moped, or other cycle or two-wheeled vehicle. The hitch is mounted relatively permanently to the seat post of the towing cycle but is free to swivel around said seat post as the trailer tracks around curves. The frame of the trailer to be towed has a frame the front reach of which consists of transversely disposed rounded bar or tubing. The essential universal-joint connection that makes a one-wheeled trailer feasible is completed by this rounded front reach of the frame captured rotatably within a horizontally disposed, rearward-facing slot in the hitch block. The capture is completed by means of a vertical, quickly removable pin preferably containing a spring-ball plunger. The pin is inserted behind said bar or tubing.

Abstract: In conjunction with a cycle trailer having a frame the front reach of which consists of rounded tubing or bar, a universal-joint hitch consisting essentially of two diametrically opposed wafer-like sector bearings each of which contains on its face multiple diametrally disposed sector channels, in order to render easy the assembly of the trailer to one such sector channel in the bearings. The bearings include trunnions and integral annular thrust surfaces on their opposite faces. Through the thrust surfaces, the bearings are constrained to bear on the rounded tubing or bar of the frame from opposite directions by clamping and mounting arrangements which may include a hinge on one side of the bearings and a hand nut on the opposite side. This hand nut, when employed, is restrained from unwanted loosening by contrived interference or engagement, most conveniently through glancing interference of protrusions of its handle with the trunnion of one sector bearing.