Patents by Inventor Bernhard Breit
Bernhard Breit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220184195Abstract: The present invention is inter alia concerned with an inhibitor selected from the group consisting of a selective KMT9-inhibitor, a selective METTL21A-inhibitor and a selective METTL21B-inhibitor for use in the treatment of cancer. KMT9, METTL21A and METTL21B are characterized herein for the first time as histone methyl transferases, and inhibitors of the same can be used for treating cancer.Type: ApplicationFiled: September 18, 2019Publication date: June 16, 2022Inventors: Roland Schüle, Eric Metzger, Sheng Wang, Manfred Jung, Nicolas Barthes, Bernhard Breit, Daad Sarraf, Tabea Pappert
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Publication number: 20220055989Abstract: Compounds of formula (1) or (2) and their use in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.Type: ApplicationFiled: December 19, 2019Publication date: February 24, 2022Inventors: Stefan Gunther, Daniel Wohlwend, Martin Hugle, Xavier Lucas, Pierre-Michel Regenass, Mehrosh Pervaiz, Roben Warstat, Bernhard Breit, Oliver Einsle
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Publication number: 20140343049Abstract: The present invention relates to compounds of formula (IA) wherein QA is QA1 or QA2 P is P1, heterocycyl or heterocyclyl substituted by one to five Z; and wherein A1, A2, A3, A4, G1, Z, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (IA), to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising the compounds of formula (IA) and to methods of using the compounds of formula (IA) to control insect, acarine, nematode and mollusc pests.Type: ApplicationFiled: August 10, 2012Publication date: November 20, 2014Applicant: SYNGENTA PARTICIPATIONS AGInventors: Julie Clementine Toueg, Tomas Smejkal, Sebastian Volker Wendeborn, Jerome Yves Cassayre, Myriem El Qacemi, Bernhard Breit, Lisa Diab, Regis Jean Georges Mondiere, Nicolas Poirier
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Publication number: 20140235533Abstract: The present invention provides compounds of formula I wherein Q is Q1 or Q2; A1, A2, A3 and A4 are independently of each other C—H, C—R7, or nitrogen; R1 is C1-C8haloalkyl; R2 is aryl or aryl substituted by one to five R11, or heteroaryl or heteroaryl substituted by one to five R11; and R3, R4, R5, R6 and R7 are as defined in the claims. The invention also provides methods of controlling insects, acarines, nematodes or molluscs which methods comprise applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).Type: ApplicationFiled: August 10, 2012Publication date: August 21, 2014Applicant: SYNGENTA PARTICIPATIONS AGInventors: Tomas Smejkai, Sebastian Volker Wendeborn, Jerome Yves Cassayre, Myriem El Qacemi, Bernhard Breit, Lisa Diab, Regis Jean Georges Mondiere
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Patent number: 8212065Abstract: A method for the production of optically active ?-alkylcarbonyl compounds with retention of the stereo information of the starting compound. The starting compound used here is a carbonyl compound which has, in the ?-position, a leaving group which is substituted by an alkyl group with inversion of the configuration. The substitution of the leaving group is effected with the use of an alkylmagnesium Grignard and a zinc (II) salt or a zinc organyl. The method permits the production of optically active ?-alkylcarbonyl compounds at very mild temperatures (for example 0° C.) with the use of starting compounds which are easy to prepare and economical and nontoxic catalysts, it also being possible to achieve a very high yield.Type: GrantFiled: September 18, 2008Date of Patent: July 3, 2012Assignee: Albert-Ludwigs-Universitat FreiburgInventors: Bernhard Breit, Christopher Studte
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Publication number: 20110282075Abstract: The present invention relates to the chemical synthesis of vittatalactone, the aggregation pheromone of the striped cucumber beetle, Acalymma vittatum.Type: ApplicationFiled: March 23, 2011Publication date: November 17, 2011Applicant: Albert-Ludwigs-Universitat FreiburgInventor: Bernhard BREIT
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Publication number: 20110028746Abstract: The present invention relates to a process for preparing aldehydes by reacting an ?,?-unsaturated carboxylic acid or a salt thereof with carbon monoxide and hydrogen in the presence of a catalyst comprising at least one complex of a metal of transition group VIII of the Periodic Table of the Elements with at least one compound of the formula (I), where Pn is pnicogen; W is a divalent bridging group having from 1 to 8 bridge atoms between the flanking bonds; R1 is a functional group capable of forming at least one intermolecular, noncovalent bond with the —X(?O)OH group of the compound of the formula (I); R2, R3 are each in each case optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl or together with the pnicogen atom and together with the groups Y2 and Y3 if present form an optionally fused and optionally substituted 5- to 8-membered heterocycle; a, b and c are each 0 or 1; and Y1,2,3 are each, independently of one another, O, S, NRa or SiRbRc, where Ra,b,c are each H or in each cType: ApplicationFiled: March 25, 2009Publication date: February 3, 2011Applicant: BASF SEInventors: Jens Rudolph, Joachim Schmidt-Leithoff, Rocco Paciello, Bernhard Breit, Thomas Smejkal
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Publication number: 20100305352Abstract: A method for the production of optically active ?-alkylcarbonyl compounds with retention of the stereo information of the starting compound. The starting compound used here is a carbonyl compound which has, in the ?-position, a leaving group which is substituted by an alkyl group with inversion of the configuration. The substitution of the leaving group is effected with the use of an alkylmagnesium Grignard and a zinc (II) salt or a zinc organyl. The method permits the production of optically active ?-alkylcarbonyl compounds at very mild temperatures (for example 0° C.) with the use of starting compounds which are easy to prepare and economical and nontoxic catalysts, it also being possible to achieve a very high yield.Type: ApplicationFiled: September 18, 2008Publication date: December 2, 2010Inventors: Bernhard Breit, Christopher Studte
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Publication number: 20100240896Abstract: The present invention relates to a process for the hydroformylation of compounds of the formula (I), where X is C, P(Rx), P(O—Rx) S or S(?O), where Rx is H, alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; A is a divalent bridging group having from 1 to 4 bridging atoms; and R1 is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; or salts thereof; in which the compound of the formula (I) is reacted with carbon monoxide and hydrogen in the presence of a catalyst comprising a complex of a metal of transition group VIII with a compound of the formula (II), where Pn is a pnicogen atom; W is a divalent bridging group having from 1 to 8 bridging atoms; R2 is a functional group capable of forming an intermolecular, noncovalent bond with the group —X(?O)OH; R3, R4 are each alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; a, b, c are each 0 or 1; and Y1, Y2 and Y3 are each O, S, NRa or SiRbRc; and also compounds of the formula (II.Type: ApplicationFiled: November 4, 2008Publication date: September 23, 2010Applicant: BASF SEInventors: Jens Rudolph, Joachim Schmidt-Leithoff, Rocco Paciello, Bernhard Breit, Tomas Smejkal
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Patent number: 7696349Abstract: The present invention relates to a process for asymmetric synthesis in the presence of a chiral catalyst comprising at least one complex of a metal of transition group VIII with ligands capable of dimerization via noncovalent bonds, such catalysts and their use.Type: GrantFiled: September 24, 2008Date of Patent: April 13, 2010Assignee: BASF SEInventors: Christoph Jäkel, Martin Volland, Thomas Mackewitz, Rocco Paciello, Bernhard Breit, Wolfgang Seiche, Martine Weis, Christoph Waloch
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Publication number: 20090326226Abstract: The present invention relates to a process for asymmetric synthesis in the presence of a chiral catalyst comprising at least one complex of a metal of transition group VIII with ligands capable of dimerization via noncovalent bonds, such catalysts and their use.Type: ApplicationFiled: September 24, 2008Publication date: December 31, 2009Applicant: BASF AKTIENGESELLSCHAFTInventors: Christoph Jakel, Martin Volland, Thomas Mackewitz, Rocco Paciello, Bernhard Breit, Wolfgang Seiche, Martine Weis, Christoph Waloch
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Patent number: 7442842Abstract: The present invention relates to a process for asymmetric synthesis in the presence of a chiral catalyst comprising at least one complex of a metal of transition group VIII with ligands capable of dimerization via noncovalent bonds, such catalysts and their use.Type: GrantFiled: November 24, 2004Date of Patent: October 28, 2008Assignee: BASF SEInventors: Christoph Jäkel, Martin Volland, Thomas Mackewitz, Rocco Paciello, Bernhard Breit, Wolfgang Seiche, Martine Weis, Christoph Waloch
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Publication number: 20070073092Abstract: The present invention relates to a process for asymmetric synthesis in the presence of a chiral catalyst comprising at least one complex of a metal of transition group VIII with ligands capable of dimerization via noncovalent bonds, such catalysts and their use.Type: ApplicationFiled: November 24, 2004Publication date: March 29, 2007Applicant: BASF AktiengesellschaftInventors: Christoph Jäkel, Martin Volland, Thomas Mackewitz, Rocco Paciello, Bernhard Breit, Wolfgang Seiche, Martine Weis, Christoph Waloch
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Patent number: 7049473Abstract: The present invention relates to a process for hydroformylating in the presence of a catalyst comprising at least one complex of a metal of transition group VIII with mono-phosphorus compounds which are capable of dimerizing via noncovalent bonds as ligands, to such catalysts and to their use.Type: GrantFiled: March 23, 2004Date of Patent: May 23, 2006Assignee: BASF AktiengesellschaftInventors: Thomas Mackewitz, Martin Volland, Rocco Paciello, Ansgar Schäfer, Bernhard Breit, Wolfgang Seiche
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Publication number: 20040199024Abstract: The present invention relates to a process for hydroformylating in the presence of a catalyst comprising at least one complex of a metal of transition group VIII with mono-phosphorus compounds which are capable of dimerizing via noncovalent bonds as ligands, to such catalysts and to their use.Type: ApplicationFiled: March 23, 2004Publication date: October 7, 2004Inventors: Thomas Mackewitz, Martin Volland, Rocco Paciello, Ansgar Schafer, Bernhard Breit, Wolfgang Seiche
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Patent number: 6509505Abstract: Phosphabenzene compounds of the formula (I) where the radicals R1 to R13 are, independently of one another, hydrogen, COOM, SO3M, NR3X, NR2, OR, COOR or SR (where M=hydrogen, NH4 or alkali metal, X=anion, R=hydrogen or C1-C6-alkyl), or C1-C12-alkyl, C6-C12-aryl, C7-C12-aralkyl, C7-C12-alkaryl or C3-C6-heteroaromatics, where the alkyl, aryl, alkaryl and aralkyl radicals may bear the abovementioned radicals as substituents and two or more of the radicals may be joined to form aliphatic or fused-on rings, where at least one of the radicals R4 and R8 and at least one of the radicals R9 and R13 is not hydrogen, can be used for preparing hydroformylation catalysts.Type: GrantFiled: September 11, 2001Date of Patent: January 21, 2003Assignee: BASF AktiengesellschaftInventors: Rocco Paciello, Thomas Mackewitz, Michael Röper, Bernhard Breit
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Patent number: 6255532Abstract: A process for the preparation of phosphabenzene compounds of the formulae I and II where R1 to R6, independently of one another, are hydrogen, COOM SO3M, NR3X, NR2, OR, COOR or SR, where M is hydrogen, NH4 or an alkali metal, X is an anion, R is hydrogen, C1-6-alkyl, or C1-12-alkyl, C6-12-aryl, C7-12-aralkyl or C3-6-heterocycloalkyl having 1 to 3 heteroatoms which may be substituted by the above radicals or linked to form fused rings, and —W— is a bridge comprising a covalent bond, an oxo group, a sulfur group, an amino group, a di-C1-6-alkylsilicon group or a C1-16-radial, which may be part of one or more linked cyclic or aromatic rings and may be interrupted by 1 to 3 heteroatoms, where the phosphabenzene ring o- or m-position not bonded to the bridge may carry one of the radicals R1 to R6, with the exception of bis-3,3′-(2,4,6-triphenyl-3-phosphabenzene)-1,1-biphenyl, by reacting corresponding pyrilium salts with PH3 in the presence of a catalytic amount of acid and inType: GrantFiled: March 30, 2000Date of Patent: July 3, 2001Assignee: BASF AktiengesellschaftInventors: Rocco Paciello, Edgar Zeller, Bernhard Breit, Michael Röper
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Patent number: 6252117Abstract: Phosphabenzene compounds of the formulae I and II where R1 to R6 are identical or different and are, for example, hydrogen, are prepared by reacting corresponding pyrylium salts with PH3 in the presence or absence of a solvent or diluent. The pyrylium salts are combined with PH3 at above 0° C. and reacted at a temperature in the range from 0° C. to 200° C. and a pressure above 1 bar without addition of an acid catalyst or a base.Type: GrantFiled: March 14, 2000Date of Patent: June 26, 2001Assignee: BASF AktiengesellschaftInventors: Thomas Mackewitz, Michael Röper, Bernhard Breit