Abstract: A method for colon screening and collecting data by using Magnetic Particle Imaging wherein an imaging magnetic field is generated with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated. The spatial location of both sub-areas in the area of examination is modified so that the magnetization of said particles changes locally. Signals are acquired and are evaluated to obtain information about the spatial distribution of the signals in the area of examination. The method may be carried out during an entire peristaltic cycle in a colon portion or segment.

Abstract: Method for the spatially resolved determination of physical, chemical and/or biological properties or state variables and/or the change therein in an examination area of an examination object by determining the change in the spatial distribution and/or the mobility, particularly the mobility in rotation, of magnetic particles in this examination area or in parts thereof as a function of the effect of physical, chemical and/or biological influencing variables on at least a part-area and/or in the physical, chemical and/or biological conditions in at least a part-area of the examination area, by means of the following steps: a) introducing covered and/or coated magnetic particles with at least one solid, viscous and/or liquid shell or coating into at least part of the examination area and/or introducing magnetic particles into at least part of the examination area and/or covering and/or coating at least some of these particles in the examination area, b) generating a magnetic field with a spatial profile of the

Abstract: A multimodal fiducial marker for registration of multimodal data, including a first portion comprising magnetic material visible in magnetic particle imaging (MPI) data obtained by a magnetic particle imaging method and a second portion comprising a second material visible in image data obtained by another imaging method, which image data is registrable with the MPI data and a corresponding marker arrangement.

Abstract: The present invention relates to an apparatus and a method for targeted drug delivery by use of a drug substance comprising a drug and magnetic particles.

Abstract: The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view (28), in particular for examination of human patients.

Abstract: The present invention relates to manufacturing of litz wire. In order to provide thinner litz wires, a system (100) for manufacturing litz wire is provided, the system comprising a provision unit (102) and a conversion unit (104). The provision unit is configured to provide a strand (106) with a plurality (108) of thin conductive wires (110) embedded in a matrix (112), which matrix is having first characteristics comprising metallic connection of the conductive wires and the matrix, and comprising electrical conductivity for electrically connecting of the conductive wires and the matrix. The conversion unit is configured to convert at least a part of the matrix into material (114) having second characteristics comprising electrical insulation for providing at least a part of the plurality of thin conductive wires with an electrical insulation.

Abstract: The present invention relates to a method of determining physical, chemical and/or biological state variables, particularly substance concentrations, temperature, pH and/or physical fields, and/or the change in these state variables in an examination area of an examination object by determining the change in the spatial distribution of magnetic particles in this examination area as a function of the effect of influencing variables on at least a partarea and/or in the conditions in at least a part-area of the examination area, by means of the following steps: a) introducing magnetic particles into at least part of the examination area in a first state in which in the examination area or in parts thereof at least some of the magnetic particles that are to be examined are agglomerated and/or coupled to one another in pairs or more, or introducing magnetic particles into at least part of the examination area in a second state in which the particles are deagglomerated and/or decoupled and can be agglomerated and/o

Abstract: A system for determining the spatial distribution of magnetic particles in an examination area. Magnetic field generator generates a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength in which the magnetization of the particles is in a state of non-saturation, whereas they are in a state of saturation in the remaining region. By an arrangement to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by a detector. At least one of the magnetic field generator, the arrangement and the detector are arranged at least partially on a medical instrument.

Abstract: Method for influencing and/or detecting magnetic particles in a field of view. Selection coils/magnets generate a magnetic selection field and drive coils generate a magnetic drive field for moving a field-free point along a predetermined trajectory through the field of view, changing the magnetization of the magnetic material locally. The drive field comprises a time-dependent oscillating drive field current per drive field coil having one or more individual oscillating frequencies and one or more individual current amplitudes and being generated by a corresponding drive field voltage generated by a superposition of a number of drive field voltage components including a drive field voltage component per drive field coil, wherein a drive field voltage component corresponding to a drive field coil comprises one or more sub-components, each having an individual voltage amplitude and having the same individual oscillating frequency as the respective drive field current of said particular drive field coil.

Abstract: The present invention relates to an apparatus (100) for influencing and/or detecting magnetic particles in a field of view (28), in particular an MPI apparatus. The apparatus comprises selection field elements (116) for generating a magnetic selection field (50), drive field coils (124; 125, 126, 127) for changing the position in space of the two sub-zones (52, 54) by means of a magnetic drive field, focus field elements (116) for changing the position in space of the field of view (28) by means of a magnetic focus field, and receiving elements (148) for acquiring detection signals. A static system function of the apparatus is obtained in the absence of a magnetic focus field, from which an extended system function is generated by shifting a time-domain representation of said static system function proportional to the changes of the position of the field of view caused by appliance of the magnetic focus field.

Abstract: A magnetic stimulator for stimulation of a tissue by a magnetic field, having a pulse generator device which comprises a pulse capacitor which can be charged by a charging circuit in order to generate a pulse sequence consisting of pulses and having an adjustable repeat rate; and having a programmable control device which adjusts the pulse generator device to generate a complex pulse sequence, which comprises individually configurable pulses, wherein the generated complex pulse sequence is applied to a stimulation coil in order to generate the magnetic field.

Abstract: The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view (28). The apparatus comprises selection means for generating a magnetic selection field (50) and drive and receiving means comprising one or more combined drive field and selection coils (441) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) and for acquiring detection signals. A balanced bridge unit (160) comprising inductive or capacitive coupling elements (411, 421) is provided between the drive field signal generator unit (122) and the signal receiving unit (140) as a light-weight, inexpensive and easily implementable solution for reducing the harmonic background.

Abstract: The present invention relates to an apparatus for moving a target element which comprises a magnetic material and an active agent, through an object, placing the target element at a predetermined position within the object and activating the active agent.

Abstract: An arrangement (10) and a method for imaging an object including a vessel (400), using magnetic particle imaging is provided. An image of the vessel (400) is reconstructed based on a known concentration of the magnetic particles (100) within the vessel (400) and on vessel tree data about the progression of said vessel (400). The reconstruction comprises defining cylinder elements (440) around an approximated image and stepwise and separately adapting the radii of the cylinder elements by integrating over the signal intensity of the cylinder elements, wherein the radii are adapted such that the integrated signal intensity over the cylinder elements equals the intensity expected from the known concentration of the magnetic particles in the vessel.

Abstract: The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view (28). The apparatus comprises selection means for generating a magnetic selection field (50) and drive and receiving means comprising one or more combined drive field and selection coils (441) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) and for acquiring detection signals. A balanced bridge unit (160) comprising inductive or capacitive coupling elements (411, 421) is provided between the drive field signal generator unit (122) and the signal receiving unit (140) as a light-weight, inexpensive and easily implementable solution for reducing the harmonic background.

Abstract: In Magnetic Particle Imaging (MPI) the reconstruction requires the knowledge of a so called system function. This function describes the relation between spatial position and frequency response. For reasonable resolutions and field of views the system function becomes quite large, resulting in large acquisition times for the system function and high memory demand during reconstruction. The present invention proposes to reduce the size of the system function matrix by making use of structural properties of the matrix. Such properties are, for instance, spatial symmetries reducing the number of columns and identical responses at different frequencies reducing the number of rows. In other embodiments the matrix can be transformed to a sparse representation using appropriate base functions.

Abstract: The present invention relates to an apparatus (100) for influencing and/or detecting magnetic particles in a field of view (28), wherein the field of view (28) comprises at least one sub field of interest covering at least a portion of an object of interest containing magnetic particles.

Abstract: The present invention relates to an apparatus (100) for detecting magnetic particles in a field of view (28), which apparatus comprises selection means, drive means, receiving means for acquiring detection signals, and reconstruction means (152) for reconstructing an image of the field of view (28) from detection signals, said detection signals including a plurality of frequency components, wherein one or more frequency components are selected and/or weighted by use of a frequency component specific signal quality factor obtained from background signal measurements and wherein only selected and/or weighted frequency components are used for reconstruction of the image.

Abstract: The present invention relates to a magnetic device (400a) that can be localized and moved by a magnetic particle imaging apparatus, said magnetic device comprising a force-receiving portion (410a) formed by one or more ferromagnetic force-receiving elements, which force-receiving portion can be moved and/or oriented by use of magnetic fields, and a localization portion (420a) formed by one or more soft-magnetic localization elements arranged within or at a predetermined distance from said force-receiving portion, which localization portion provides response signals in response to the movement of a substantially field free area of a magnetic field over the location of the localization portion.

Abstract: The present invention relates to a device for determining mechanical, particularly elastic, parameters of an examination object, comprising a) at least one arrangement for determining the spatial distribution of magnetic particles in at least one examination area of the examination object, comprising a means for generating a magnetic field with a spatial profile of the magnetic field strength such that there is produced in at least one examination area a first part-area having a low magnetic field strength and a second part-area having a higher magnetic field strength, a means for detecting signals which depend on the magnetization in the examination object, particularly in the examination area, that is influenced by a spatial change in the particles, and a means for evaluating the signals so as to obtain information about the, in particular temporally changing, spatial distribution of the magnetic particles in the examination area; and b) at least one means for generating mechanical displacements, in particu